Cardiopulmonary Risk Assessment from Smoke Exposure at the Wildland Urban Interface
荒地城市界面烟雾暴露的心肺风险评估
基本信息
- 批准号:10360921
- 负责人:
- 金额:$ 70.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-07 至 2026-11-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAdultAdvocateAerosolsAnimalsApolipoprotein EAreaAtherosclerosisAutomobile DrivingAwarenessBehaviorBiologicalBiologyBloodBlood CirculationBlood PressureCaliforniaCardiacCardiopulmonaryCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemCase ManagerCellsCharacteristicsChemicalsChemistryChronicCommunitiesComplexComplex MixturesComputer ModelsCouplingDangerousnessDepositionDevelopmentDoseEFRACEngineeringExposure toFire - disastersFosteringFrequenciesFunctional disorderGasesGenerationsGoalsGrantHealthHealthcareHeartHouseholdHousingHumanIndividualInfiltrationInflammationInflammatoryInhalationInhalation ToxicologyInterdisciplinary StudyKnowledgeLeadLifeLinkLungMeasuresModelingMorbidity - disease rateMusObstructive Lung DiseasesOrganOutcomeParticle SizeParticulateParticulate MatterPersonsPoliciesPolymethyl MethacrylatePopulationPopulations at RiskPseudotsuga menziesiiPublic HealthPulmonary Heart DiseaseRecurrenceResearchResearch PersonnelRespiratory DiseaseRespiratory MechanicsRisk AssessmentRodentRoleSerumSeveritiesSmokeSourceStreamTestingTissuesToxinTrace metalWildfireWood materialbiomass smokebiomechanical testcardiopulmonary systemcareercareer developmentchemokinecostcytokinedensityepidemiologic datafine particlesin vivo imagingmortalitymouse modelnovelparticlepollutantpolyurethane foampressureprogramsrespiratoryresponserisk stratificationsmoke inhalationsymposiumultrafine particle
项目摘要
PROJECT SUMMARY
Acute and chronic wildland fire smoke inhalation have been linked to increased mortality as well as respiratory
and cardiovascular morbidity, though the extent to which the frequency and duration of exposure or the
chemical and particle profiles of the smoke contribute to the observed health effects remains unknown. As the
occurrences of wildland fires and number of people living at the wildland urban interface (WUI) continue to
increase, prolonged inhalation of wildland fire smoke poses a serious threat to public health. Due to this, there
is an urgent need to better understand the adverse cardiopulmonary outcomes associated with the exposure to
wildland urban smoke. The smoke that arises from wildland fires at the WUI is a complex mixture of gases,
trace metals, and fine and ultrafine particles. The latter are particularly dangerous for human health, since they
deposit in the deep regions of the lungs and may translocate into the blood stream, increasing the oxidative and
inflammatory burden, both locally and systemically. Prolonged inflammation can lead to the development of
obstructive lung disease and atherosclerosis. To investigate the link between exposure to WUI smoke and
development of cardiopulmonary dysfunction, our interdisciplinary team brings together expertise in fire
generation and characterization, rodent aerosol exposures, respiratory mechanics, lung biology, and
cardiovascular physiology. To fulfill our goals, we will create lab-scale smoke using materials representative of
WUI regions in Southern California and we will deliver it to mice. In Aim 1, we will investigate the role of
frequency and duration of the exposure, as well as particulate concentration of the wildland fire smoke. In Aim
2, we will focus on the relative contribution of different fuel sources characteristic of the WUI. Furthermore, as
part of this ONES early-stage-investigator project, the PI and co-Is will generate an external advisory panel
consisting of inhalation toxicology researchers, public health advocates, and fire protection experts.
Dissemination of new knowledge gained from this proposal to the community will be a vital part of this
endeavor.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jessica M Oakes其他文献
Jessica M Oakes的其他文献
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{{ truncateString('Jessica M Oakes', 18)}}的其他基金
Coupling MRI-Derived Ventilation with Computational Models to Assess Inhaled Aerosol Treatment Feasibility in Severe Asthmatic Adults
将 MRI 衍生通气与计算模型相结合,评估吸入气雾剂治疗成人严重哮喘的可行性
- 批准号:
9441318 - 财政年份:2017
- 资助金额:
$ 70.7万 - 项目类别:
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