权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Cardiopulmonary Risk Assessment from Smoke Exposure at the Wildland Urban Interface

荒地城市界面烟雾暴露的心肺风险评估

基本信息

批准号：
10360921
负责人：
Jessica M Oakes
金额：
$ 70.7万
依托单位：
NORTHEASTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-07 至 2026-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10360921
关键词：
Acute Adult Advocate Aerosols Animals Apolipoprotein E Area Atherosclerosis Automobile Driving Awareness Behavior Biological Biology Blood Blood Circulation Blood Pressure California Cardiac Cardiopulmonary Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Case Manager Cells Characteristics Chemicals Chemistry Chronic Communities Complex Complex Mixtures Computer Models Coupling Dangerousness Deposition Development Dose EFRAC Engineering Exposure to Fire - disasters Fostering Frequencies Functional disorder Gases Generations Goals Grant Health Healthcare Heart Household Housing Human Individual Infiltration Inflammation Inflammatory Inhalation Inhalation Toxicology Interdisciplinary Study Knowledge Lead Life Link Lung Measures Modeling Morbidity - disease rate Mus Obstructive Lung Diseases Organ Outcome Particle Size Particulate Particulate Matter Persons Policies Polymethyl Methacrylate Population Populations at Risk Pseudotsuga menziesii Public Health Pulmonary Heart Disease Recurrence Research Research Personnel Respiratory Disease Respiratory Mechanics Risk Assessment Rodent Role Serum Severities Smoke Source Stream Testing Tissues Toxin Trace metal Wildfire Wood material biomass smoke biomechanical test cardiopulmonary system career career development chemokine cost cytokine density epidemiologic data fine particles in vivo imaging mortality mouse model novel particle pollutant polyurethane foam pressure programs respiratory response risk stratification smoke inhalation symposium ultrafine particle

项目摘要

PROJECT SUMMARY Acute and chronic wildland fire smoke inhalation have been linked to increased mortality as well as respiratory and cardiovascular morbidity, though the extent to which the frequency and duration of exposure or the chemical and particle profiles of the smoke contribute to the observed health effects remains unknown. As the occurrences of wildland fires and number of people living at the wildland urban interface (WUI) continue to increase, prolonged inhalation of wildland fire smoke poses a serious threat to public health. Due to this, there is an urgent need to better understand the adverse cardiopulmonary outcomes associated with the exposure to wildland urban smoke. The smoke that arises from wildland fires at the WUI is a complex mixture of gases, trace metals, and fine and ultrafine particles. The latter are particularly dangerous for human health, since they deposit in the deep regions of the lungs and may translocate into the blood stream, increasing the oxidative and inflammatory burden, both locally and systemically. Prolonged inflammation can lead to the development of obstructive lung disease and atherosclerosis. To investigate the link between exposure to WUI smoke and development of cardiopulmonary dysfunction, our interdisciplinary team brings together expertise in fire generation and characterization, rodent aerosol exposures, respiratory mechanics, lung biology, and cardiovascular physiology. To fulfill our goals, we will create lab-scale smoke using materials representative of WUI regions in Southern California and we will deliver it to mice. In Aim 1, we will investigate the role of frequency and duration of the exposure, as well as particulate concentration of the wildland fire smoke. In Aim 2, we will focus on the relative contribution of different fuel sources characteristic of the WUI. Furthermore, as part of this ONES early-stage-investigator project, the PI and co-Is will generate an external advisory panel consisting of inhalation toxicology researchers, public health advocates, and fire protection experts. Dissemination of new knowledge gained from this proposal to the community will be a vital part of this endeavor.

项目总结