Cardiopulmonary Risk Assessment from Smoke Exposure at the Wildland Urban Interface

荒地城市界面烟雾暴露的心肺风险评估

基本信息

  • 批准号:
    10360921
  • 负责人:
  • 金额:
    $ 70.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-02-07 至 2026-11-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Acute and chronic wildland fire smoke inhalation have been linked to increased mortality as well as respiratory and cardiovascular morbidity, though the extent to which the frequency and duration of exposure or the chemical and particle profiles of the smoke contribute to the observed health effects remains unknown. As the occurrences of wildland fires and number of people living at the wildland urban interface (WUI) continue to increase, prolonged inhalation of wildland fire smoke poses a serious threat to public health. Due to this, there is an urgent need to better understand the adverse cardiopulmonary outcomes associated with the exposure to wildland urban smoke. The smoke that arises from wildland fires at the WUI is a complex mixture of gases, trace metals, and fine and ultrafine particles. The latter are particularly dangerous for human health, since they deposit in the deep regions of the lungs and may translocate into the blood stream, increasing the oxidative and inflammatory burden, both locally and systemically. Prolonged inflammation can lead to the development of obstructive lung disease and atherosclerosis. To investigate the link between exposure to WUI smoke and development of cardiopulmonary dysfunction, our interdisciplinary team brings together expertise in fire generation and characterization, rodent aerosol exposures, respiratory mechanics, lung biology, and cardiovascular physiology. To fulfill our goals, we will create lab-scale smoke using materials representative of WUI regions in Southern California and we will deliver it to mice. In Aim 1, we will investigate the role of frequency and duration of the exposure, as well as particulate concentration of the wildland fire smoke. In Aim 2, we will focus on the relative contribution of different fuel sources characteristic of the WUI. Furthermore, as part of this ONES early-stage-investigator project, the PI and co-Is will generate an external advisory panel consisting of inhalation toxicology researchers, public health advocates, and fire protection experts. Dissemination of new knowledge gained from this proposal to the community will be a vital part of this endeavor.
项目摘要 急性和慢性野火烟雾吸入与死亡率增加以及呼吸道疾病有关。 和心血管疾病的发病率,虽然在何种程度上的频率和持续时间的接触或 烟雾的化学和颗粒特征对观察到的健康影响的贡献仍然未知。为 荒地火灾的发生和居住在荒地城市界面(WUI)的人数继续增加 增加,长时间吸入野火烟雾对公众健康构成严重威胁。因此,在 迫切需要更好地了解与暴露于 荒野城市烟雾。WUI的野火产生的烟雾是一种复杂的气体混合物, 微量金属和精细和超细颗粒。后者对人类健康特别危险,因为它们 存款在肺部的深部区域,并可能转移到血液中,增加氧化和 炎症负担,包括局部和全身。长期的炎症会导致 阻塞性肺病和动脉粥样硬化。研究暴露于WUI烟雾与 心肺功能障碍的发展,我们的跨学科团队汇集了消防专业知识, 生成和表征,啮齿动物气溶胶暴露,呼吸力学,肺生物学,以及 心血管生理学为了实现我们的目标,我们将使用代表以下物质的材料制造实验室规模的烟雾 WUI地区在南加州,我们将提供给小鼠。在目标1中,我们将研究 暴露的频率和持续时间,以及荒地火灾烟雾的颗粒浓度。在Aim中 2、我们将重点关注不同燃料源特征对WUI的相对贡献。此外如 作为ONES早期研究项目的一部分,PI和co-Is将组建一个外部顾问小组 包括吸入毒理学研究人员、公共卫生倡导者和消防专家。 将从这项建议中获得的新知识传播给社区将是这一计划的重要组成部分 奋进。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jessica M Oakes其他文献

Jessica M Oakes的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jessica M Oakes', 18)}}的其他基金

Coupling MRI-Derived Ventilation with Computational Models to Assess Inhaled Aerosol Treatment Feasibility in Severe Asthmatic Adults
将 MRI 衍生通气与计算模型相结合,评估吸入气雾剂治疗成人严重哮喘的可行性
  • 批准号:
    9441318
  • 财政年份:
    2017
  • 资助金额:
    $ 70.7万
  • 项目类别:

相似海外基金

Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
  • 批准号:
    MR/Z503605/1
  • 财政年份:
    2024
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
  • 批准号:
    2336167
  • 财政年份:
    2024
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
  • 批准号:
    2402691
  • 财政年份:
    2024
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
  • 批准号:
    2341428
  • 财政年份:
    2024
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
  • 批准号:
    24K12150
  • 财政年份:
    2024
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
  • 批准号:
    DE240100561
  • 财政年份:
    2024
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
  • 批准号:
    10065645
  • 财政年份:
    2023
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
  • 批准号:
    23K09542
  • 财政年份:
    2023
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
  • 批准号:
    23K07552
  • 财政年份:
    2023
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
  • 批准号:
    23K07559
  • 财政年份:
    2023
  • 资助金额:
    $ 70.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了