Elucidating ecological mechanisms for propagation of antibiotic resistance genes via massively parallelized single-cell sequencing

通过大规模并行单细胞测序阐明抗生素抗性基因传播的生态机制

基本信息

  • 批准号:
    10362535
  • 负责人:
  • 金额:
    $ 23.33万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-03-02 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY The accelerating emergence of antibiotics resistant bacteria has become a global health crisis, costing tens of thousands of lives and hundreds of billions of dollars every year. Horizontal transfer of antibiotics resistance genes (ARGs) is a key mechanism driving the emergence of antibiotic resistant strains, but the ecological processes impacting the transmission of these genes through microbial communities are largely unknown. To address this knowledge gap, we propose to develop an ultrahigh-throughput single cell sequencing technology to identify the associations between ARGs and microbial taxa. This method will be used to decipher the time- dependent horizontal gene transfer networks underlying ARG spread in a human gut microbiome in response to clinically relevant antibiotics. The new technology will enable single cell analysis of microbial communities at an unprecedented scale. Deciphering the horizontal gene transfer networks responsible for ARG dissemination will deepen our understanding of the ecological interactions involved in the emergence of antibiotic resistant bacteria and inform the design of interventions to substantially reduce ARG propagation. A detailed understanding of the environmental and ecological factors influencing horizontal gene transfer is critical to combating infectious diseases.
项目总结

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Integrating Systems and Synthetic Biology to Understand and Engineer Microbiomes.
  • DOI:
    10.1146/annurev-bioeng-082120-022836
  • 发表时间:
    2021-07-13
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
    Leggieri PA;Liu Y;Hayes M;Connors B;Seppälä S;O'Malley MA;Venturelli OS
  • 通讯作者:
    Venturelli OS
Towards a deeper understanding of microbial communities: integrating experimental data with dynamic models.
  • DOI:
    10.1016/j.mib.2021.05.003
  • 发表时间:
    2021-08
  • 期刊:
  • 影响因子:
    5.4
  • 作者:
    Qian Y;Lan F;Venturelli OS
  • 通讯作者:
    Venturelli OS
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Ophelia Venturelli其他文献

Ophelia Venturelli的其他文献

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{{ truncateString('Ophelia Venturelli', 18)}}的其他基金

Large-scale profiling of microbial and metabolic interactions between C. difficile and gut microbiota using ultrahigh-throughput droplet microfluidics
使用超高通量液滴微流体对艰难梭菌和肠道微生物群之间的微生物和代谢相互作用进行大规模分析
  • 批准号:
    10193322
  • 财政年份:
    2021
  • 资助金额:
    $ 23.33万
  • 项目类别:
Large-scale profiling of microbial and metabolic interactions between C. difficile and gut microbiota using ultrahigh-throughput droplet microfluidics
使用超高通量液滴微流体对艰难梭菌和肠道微生物群之间的微生物和代谢相互作用进行大规模分析
  • 批准号:
    10473701
  • 财政年份:
    2021
  • 资助金额:
    $ 23.33万
  • 项目类别:
Elucidating the molecular and ecological design principles of stability and assembly of the human gut microbiota
阐明人类肠道微生物群稳定性和组装的分子和生态设计原理
  • 批准号:
    10237988
  • 财政年份:
    2017
  • 资助金额:
    $ 23.33万
  • 项目类别:
Elucidating the molecular and ecological design principles of stability and assembly of the human gut microbiota
阐明人类肠道微生物群稳定性和组装的分子和生态设计原理
  • 批准号:
    9381585
  • 财政年份:
    2017
  • 资助金额:
    $ 23.33万
  • 项目类别:
Elucidating the molecular and ecological design principles of stability and assembly of the human gut microbiota
阐明人类肠道微生物群稳定性和组装的分子和生态设计原理
  • 批准号:
    10054836
  • 财政年份:
    2017
  • 资助金额:
    $ 23.33万
  • 项目类别:

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