The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)
社区研究:环境劣势与阿尔茨海默病及相关痴呆症 (ADRD)
基本信息
- 批准号:10361428
- 负责人:
- 金额:$ 630.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-01 至 2026-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmyloidAnimal ModelAreaAtlasesAutopsyBackBehaviorBiologicalBiological ProcessBiological Specimen BanksBrainCaliforniaClinicalCodeCognitiveCollaborationsConsentDataDementiaDevelopmentDiagnosisDisadvantagedDiseaseDistalDoseEducationEmploymentEthnic OriginEvaluationExposure toFoundationsFundingFutureGeographyGoalsGovernmentHealthHealth behaviorHousingHumanImpaired cognitionIncomeIndividualIndividual AdjustmentIndustryInfrastructureInterdisciplinary StudyLife Cycle StagesLinkMagnetic Resonance ImagingMediatingMediator of activation proteinMethodologyMissionNational Institute on AgingNeighborhoodsNerve DegenerationOutcomeParticipantPartner in relationshipPathologicPathway interactionsPersonsPhenotypePositron-Emission TomographyPovertyPrevalenceRaceRecording of previous eventsResearchResearch DesignResearch SupportRiskRisk AssessmentRisk FactorsSamplingScienceStandardizationSurveysTimeTissuesUniversitiesWisconsinWorkburden of illnesscognitive changecognitive functioncomorbiditydeprivationdosageeffective interventionethnic minorityimprovedindexingmortalityneighborhood associationneighborhood disadvantageneuroimagingneuropathologyneurophysiologynovelnovel therapeutic interventionnovel therapeuticsprospectivepublic databaseracial and ethnicrandomized trialsecondary outcomesexsocialsocial health determinantssocioeconomic disadvantagesocioeconomicssociologisttau Proteinstheoriestherapy development
项目摘要
Dementia due to Alzheimer’s disease and related dementias (ADRD) disproportionately impacts racial/ethnic
minorities and the socioeconomically disadvantaged. Development of effective interventions require mechanistic
understanding of distal fundamental forces, including socioeconomic context (i.e. “neighborhood disadvantage”
or the social determinants of health of a given area), that put people at “risk for [more proximal] risks” such as
individual-level income, education, health behaviors and comorbidity. Prior research supports that contextual
disadvantage is modifiable and interacts with biological processes to produce disease, yet little is known of its
impact on ADRD. Towards this, we created validated quantifications of neighborhood disadvantage for the full
US. This Area Deprivation Index (ADI) incorporates poverty, education, housing and employment indicators;
predicts disparity-related health outcomes; and is freely shared through our public platform (the Neighborhood
Atlas). We have validated survey and public data-based residential history tracing methodologies that establish
dosage and timing of neighborhood disadvantage exposure across a life-course for both living and deceased
persons. We have demonstrated that even after adjustment for individual risk factors, neighborhood
disadvantage is strongly associated with cognitive function, neurodegeneration shown on MRI, and post-mortem
AD plaque neuropathology. However, our current sample is lacking in geographic diversity and is of insufficient
size to conduct a more robust multi-factor phenotypic risk assessment of social-biological interactions and their
mechanisms; a necessary foundation towards developing new therapeutic intervention. This proposal employs
collaboration with 22 Alzheimer’s Disease Research Centers (ADRC) and their existing cognitive, neuroimaging
and neuropathology data. We take on the substantial work to create detailed residential histories for each ADRC
subject (N~9,234 living, N~10,469 brain bank) to establish a dosage and timing of neighborhood disadvantage
exposure across each life-course. Hypothesis: Larger and earlier exposures to neighborhood disadvantage will
predict lower cognitive function, faster cognitive decline and greater disease burden including AD neuropathology
among the targeted sample. Aim 1: Determine the impact of the cumulative dose and timing of neighborhood
disadvantage exposure (indexed by ADI), on cognitive function and change over time; Aim 2: on AD-specific
markers indexed by neuroimaging (amyloid and tau PET) and the secondary outcome of volumetric MRI; and
Aim 3: on neuropathologic tissue features and diagnosis. Aim 4: Using existing ADRC data and newly collected
survey data, define the extent to which individual race/ethnicity, age, sex, income, education, comorbidity and
health-behaviors mediate these relationships. The proposed project, if funded, will be the largest study of its kind
on social determinants of health in the context of AD. Successful completion will result in the development of a
novel collaborative infrastructure of contextual exposure for future social-biological phenotypic evaluation,
providing a potential pathway to new therapeutics, and directly responsive to the NIA mission.
阿尔茨海默病和相关痴呆(ADRD)导致的痴呆不成比例地影响种族/民族
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Barbara Brigitta Bendlin其他文献
Barbara Brigitta Bendlin的其他文献
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{{ truncateString('Barbara Brigitta Bendlin', 18)}}的其他基金
ß-hydroxybutyrate inhibition of pathology in Alzheimer's disease
α-羟基丁酸对阿尔茨海默病病理学的抑制作用
- 批准号:
10739679 - 财政年份:2023
- 资助金额:
$ 630.81万 - 项目类别:
The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)
社区研究:环境劣势与阿尔茨海默病及相关痴呆症 (ADRD)
- 批准号:
10803585 - 财政年份:2021
- 资助金额:
$ 630.81万 - 项目类别:
Administrative Supplement to Establish National Exposome Alzheimer's Disease and Related Dementias (ADRD) Infrastructure (Expo-AD)
建立国家阿尔茨海默氏病和相关痴呆症 (ADRD) 基础设施 (Expo-AD) 的行政补充
- 批准号:
10658250 - 财政年份:2021
- 资助金额:
$ 630.81万 - 项目类别:
The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)
社区研究:环境劣势与阿尔茨海默病及相关痴呆症 (ADRD)
- 批准号:
10580795 - 财政年份:2021
- 资助金额:
$ 630.81万 - 项目类别:
SV2A PET imaging in Alzheimer's Disease
SV2A PET 成像在阿尔茨海默病中的应用
- 批准号:
9919489 - 财政年份:2018
- 资助金额:
$ 630.81万 - 项目类别:
SV2A PET imaging in Alzheimer's Disease
SV2A PET 成像在阿尔茨海默病中的应用
- 批准号:
10403978 - 财政年份:2018
- 资助金额:
$ 630.81万 - 项目类别:














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