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New Jersey Alliance for Clinical Translational Science: NJ ACTS

新泽西临床转化科学联盟：NJ ACTS

基本信息

批准号：
10360671
负责人：
Reynold Alexander Panettieri
金额：
$ 402.66万
依托单位：
RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-11 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10360671
关键词：
AIDS/HIV problem Address Affect Age Asian Indian Behavioral Biometry Child Chronic Disease Clinical Clinical Research Clinical Sciences Clinical Trials Clinical Trials Design Cohort Studies Collaborations Communities Cuban Databases Dental Development Diagnosis Diagnostic Discipline of Nursing Disease Management Diverse Workforce Elderly Electronic Health Record Evaluation Fluorescent in Situ Hybridization Fostering Foundations Government Growth Health Health Insurance Portability and Accountability Act Health Sciences Health system Healthcare Hospitals Image Improve Access Individual Industry Informatics Infrastructure Institutes Institutional Review Boards Intervention Investigation Investments Laboratories Leadership Life Style Link Location Longevity Low income Machine Learning Medicaid Medical Mentors Methodology Methods Minority Mission Muslim population group Neighborhood Health Center New Jersey Not Hispanic or Latino Ontology Oral health Outpatients Parents Participant Pathogenesis Patient Recruitments Perception Persons Population Population Density Precision therapeutics Prediction of Response to Therapy Process Public Health Public Health Schools Recording of previous events Research Research Personnel Research Training Resources School Nursing Science Solid South Asian Special Populations Research Substance abuse problem Technology Therapeutic Intervention Training Translational Research Universities Vision Workforce Development analytical tool base biomarker discovery career development catalyst clinical care clinical database clinical investigation cognitive neuroscience cohesion community based research community engagement disease heterogeneity environmental disparity ethnic diversity ethnic minority population experience follower of religion Jewish health disparity improved industry partner innovation interdisciplinary approach logarithm medical schools member natural language next generation novel novel strategies population health preventive intervention programs racial diversity racial minority recruit relating to nervous system research clinical testing response severe mental illness skills success tool translational scientist treatment response trial design

项目摘要

Contact PD/PI: Panettieri, Reynold Alexander Project Summary/Abstract Overview Coordinated by Rutgers Biomedical and Health Sciences (RBHS), the New Jersey Alliance for Clinical and Translational Science (NJ ACTS) comprises a consortium with Rutgers and Princeton Universities (PU), NJ Institute for Technology (NJIT), medical, nursing, dental and public health schools, hospitals, community health centers, outpatient practices, industry, policymakers and health information exchanges. All Alliance universities and affiliates have provided substantial resources and contributed to the planning, development and leadership of the consortium. With access to ~7 million people, NJ ACTS serves as a ‘natural laboratory’ for translational and clinical research. With a state population of ~9 million, New Jersey ranks 11th in the US, 1st in population density and higher than average in racial and ethnic diversity. Surprisingly, NJ has no CTSA Hub to coordinate translational and clinical research. Our CTSA Hub focuses on two overarching themes: the heterogeneity of disease pathogenesis and response to treatment, and the value of linking large clinical databases with interventional clinical investigations to identify cause-and-effect and predict therapeutic responses. NJ ACTS will provide: innovative approaches to link information from large databases and electronic health records to inform clinical trial design, execution and analysis; and novel platforms for biomarker discovery using fluorescence in situ hybridization and machine learning to identify unique neural signatures of chronic illness. NJ ACTS will access a large health system with significant member diversity; a rich legacy of community engagement and community-based research platforms; and proven approaches to enhance workforce development in clinical research. With a substantial investment in streamlining research administration and IRB practices at Rutgers and with the inception of NJ ACTS, there exists an unparalleled opportunity for logarithmic growth in clinical research in New Jersey. To build our capacity for participant and clinical interactions as a CTSA Hub, the newly established Trial Accelerator and Recruitment Office will coordinate feasibility assessment, implementation, recruitment, and evaluation of clinical studies. Additionally, our organization of five clinical research units into a cohesive network provides extraordinary expertise in strategic locations to enhance participant recruitment from diverse communities with a particular focus on: children; the elderly; those with serious mental illness or substance abuse issues; low-income individuals served by Medicaid; those with HIV/AIDS; and people of all ages who are minorities, underserved, and victims of health and environmental disparities. With a history of collaboration, partners and affiliates share unique skills, expertise, training and mentoring capabilities that will be greatly amplified within the infrastructure of a CTSA Hub. Princeton and NJIT, without medical schools or hospital affiliates, seeks collaboration with Rutgers to provide clinical research platforms; Rutgers seeks the PU and NJIT expertise in novel informatics platforms, expertise in natural language and ontology, machine learning and cognitive neurosciences. Together NJ ACTS will provide an alliance that will catalyze clinical research and training across New Jersey to improve population health and contribute to the CTSA Consortium. In this revised application, the overall themes remain unchanged but Cores leadership and direction has been markedly refined. Page 337 Project Summary/Abstract Contact PD/PI: Panettieri, Reynold Alexander New Jersey Alliance for Clinical and Translational Science (NJ ACTS)

联系PD/PI: Panettieri， reynolds Alexander