New Jersey Alliance for Clinical Translational Science: NJ ACTS

新泽西临床转化科学联盟：NJ ACTS

• 批准号: 10360219
• 负责人: Reynold Alexander Panettieri
• 金额: $ 120.09万
• 依托单位: RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-11 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360219
• 关键词: AIDS/HIV problem; Address; Affect; Age; Asian Indian; Behavioral; Biometry; Child; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Cohort Studies; Collaborations; Communities; Cuban; Databases; Dental; Development; Diagnosis; Diagnostic; Discipline of Nursing; Disease Management; Diverse Workforce; Elderly; Electronic Health Record; Evaluation; Fluorescent in Situ Hybridization; Fostering; Foundations; Government; Growth; Health; Health Insurance Portability and Accountability Act; Health Sciences; Health system; Healthcare; Hospitals; Image; Improve Access; Individual; Industry; Informatics; Infrastructure; Institutes; Institutional Review Boards; Intervention; Investigation; Investments; Laboratories; Leadership; Life Style; Link; Location; Longevity; Low income; Machine Learning; Medicaid; Medical; Mentors; Methodology; Methods; Minority; Minority Groups; Mission; Muslim population group; Neighborhood Health Center; New Jersey; Not Hispanic or Latino; Ontology; Oral health; Outpatients; Parents; Participant; Pathogenesis; Patient Recruitments; Perception; Population; Population Density; Precision therapeutics; Prediction of Response to Therapy; Process; Public Health; Public Health Schools; Recording of previous events; Research; Research Personnel; Research Training; Resources; School Nursing; Science; Solid; South Asian; Special Populations Research; Substance abuse problem; Technology; Therapeutic Intervention; Training; Translational Research; Universities; Vision; Workforce Development; analytical tool; base; biomarker discovery; career development; catalyst; clinical care; clinical database; clinical investigation; cognitive neuroscience; cohesion; community based research; community engagement; disease heterogeneity; ethnic diversity; ethnic minority population; experience; follower of religion Jewish; improved; industry partner; innovation; interdisciplinary approach; logarithm; medical schools; member; natural language; next generation; novel; novel strategies; population health; preventive intervention; programs; racial diversity; racial minority; recruit; relating to nervous system; research clinical testing; response; severe mental illness; skills; success; tool; translational scientist; treatment response; trial design

SUMMARY The COVID-19 pandemic disproportionately impacts members of under-represented minority (URM) communi- ties. Unfortunately, URM and other vulnerable communities remain profoundly under-tested. As such, new ap- proaches are needed to disseminate and accomplish testing that could be generalized across the US. New Jersey can serve as a unique, virtual testing laboratory, ranking 11th in the US in population, 2nd in the US (after NY) in the per capita rate of COVID-19 deaths, and 5th in total cases and represents a highly diverse state with substantial Black and Latinx minority populations. At Rutgers, we have assembled cohorts of healthcare workers (HCWs) to monitor the spread of COVID-19 and to enroll subjects for clinical and vaccine trials. While building our cohorts, we recognized many URMs serve as HCWs or personal care aides often in lower-income roles. Further, we also found these workers were more often infected compared with those with higher income occupations. Given these observations, we posit that HCWs in occupations at lower incomes would facilitate testing among their house- holds and their communities. In a sense, these HCWs can serve as ambassadors to catalyze community-based COVID-19 testing. NJ HEROES TOO (New Jersey Healthcare Essential WoRker Outreach and Education Study - Testing Overlooked Occupations) proposes to approach URM HCWs who we have identified as index individu- als who will act as ambassadors to help expand testing in their households and extended networks. In Aim 1, we will co-design, develop and implement an innovative, HCW-centric outreach intervention strategy to engage Black and Latinx minority communities. We will explore community perceptions about COVID-19 testing, treatment, and vaccination to design COVID-19 testing materials and messages that are culturally tailored to address concerns of Black and Latinx minority communities. In Aim 2, we will conduct a mixed methods study to evaluate the effec- tiveness and cost of: (1) the HCW-focused outreach intervention strategy versus (2) standard community engaged outreach, working with community based organizations (CBOs). We will explore contextual factors (individual, family, and community) affecting COVID-19 testing implementation outcomes and scalability. The primary out- come will be uptake of COVID-19 testing in the targeted populations. We propose testing with the novel Rutgers Clinical Genomics Laboratory/RUCDR saliva test, the first FDA-authorized diagnostic test using saliva to detect SARS-CoV-2 for non-invasive, home based self-testing. We hypothesize that a participatory outreach strategy approach focused on identified index HCWs will mobilize quicker uptake of testing within community settings than best-practice CBO recruitment approaches. We also hypothesize that recruitment through index HCWs will be more successful for hard to reach participants compared to a traditional CBO approach. The strategy focusing on HCWs could easily be expanded to other front-line and essential workers, making the strategy generalizable and sustainable.

总结 COVID-19大流行对代表性不足的少数民族（URM）社区成员造成了不成比例的影响- 关系的不幸的是，城市重建运动和其他脆弱社区仍然严重缺乏考验。因此，新的AP- 需要有方法来传播和完成可以在美国推广的测试。New Jersey 可以作为一个独特的虚拟测试实验室，在美国人口中排名第11位，在美国排名第2位（仅次于纽约）， 人均COVID-19死亡率，总病例数第五，代表了一个高度多样化的国家， 黑人和拉丁裔少数民族。在罗格斯大学，我们召集了一批医疗保健工作者（HCW）， 监测COVID-19的传播，并招募受试者进行临床和疫苗试验。在建立我们的队伍的同时， 我们认识到，许多URM担任HCW或个人护理助理，通常是低收入角色。此外，我们还 发现这些工人比那些高收入职业的人更容易感染。鉴于这些 根据观察，我们认为，低收入职业的卫生工作者将有助于他们的家庭进行测试- 和他们的社区。从某种意义上说，这些HCW可以作为大使，催化基于社区的 COVID-19检测。NJ HEROES TOO（新泽西医疗保健基本工作者外展和教育研究 - 测试被忽视的占用）建议与我们已确定为索引个体的城市资源管理医疗保健工作者接触， ALS将作为大使，帮助在他们的家庭和扩展网络中扩大测试。目标1： 我将共同设计、开发和实施一项创新的、以HCW为中心的外展干预战略， 拉丁裔少数民族社区。我们将探讨社区对COVID-19检测、治疗和 疫苗接种，以设计符合文化习惯的COVID-19检测材料和信息，以解决问题 黑人和拉丁裔少数民族社区。在目标2中，我们将进行混合方法研究，以评估 （1）以卫生保健工作为重点的外展干预战略与（2）标准社区参与的效果和成本 外展，与社区组织合作。我们将探讨情境因素（个人， 家庭和社区）影响COVID-19测试实施结果和可扩展性。最主要的是- 未来将是在目标人群中进行COVID-19检测。我们建议用新的罗格斯大学 临床基因组学实验室/RUCDR唾液测试，第一个FDA授权的诊断测试使用唾液检测 SARS-CoV-2用于非侵入性、基于家庭的自我检测。我们假设一个参与式的推广策略 以确定的指标HCW为重点的方法将动员社区环境中更快地接受检测， 最佳CBO招聘方法我们还假设，通过索引HCW招募将是 与传统的CBO方法相比，对于难以接触到的参与者来说更成功。战略重点是 保健工作者可以很容易地扩大到其他一线和基本工作者，使战略具有普遍性， 可持续