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New Jersey Alliance for Clinical Translational Science: NJ ACTS

New Jersey Alliance for Clinical Translational Science: NJ ACTS
新泽西临床转化科学联盟:NJ ACTS
批准号:
10360219
负责人:
Reynold Alexander Panettieri
金额:
$120.09万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-03-11 至 2023-02-28
关键词:
AIDS/HIV problemAddressAffectAgeAsian IndianBehavioralBiometryChildChronic DiseaseClinicalClinical ResearchClinical SciencesClinical TrialsClinical Trials DesignCohort StudiesCollaborationsCommunitiesCubanDatabasesDentalDevelopmentDiagnosisDiagnosticDiscipline of NursingDisease ManagementDiverse WorkforceElderlyElectronic Health RecordEvaluationFluorescent in Situ HybridizationFosteringFoundationsGovernmentGrowthHealthHealth Insurance Portability and Accountability ActHealth SciencesHealth systemHealthcareHospitalsImageImprove AccessIndividualIndustryInformaticsInfrastructureInstitutesInstitutional Review BoardsInterventionInvestigationInvestmentsLaboratoriesLeadershipLife StyleLinkLocationLongevityLow incomeMachine LearningMedicaidMedicalMentorsMethodologyMethodsMinorityMinority GroupsMissionMuslim population groupNeighborhood Health CenterNew JerseyNot Hispanic or LatinoOntologyOral healthOutpatientsParentsParticipantPathogenesisPatient RecruitmentsPerceptionPopulationPopulation DensityPrecision therapeuticsPrediction of Response to TherapyProcessPublic HealthPublic Health SchoolsRecording of previous eventsResearchResearch PersonnelResearch TrainingResourcesSchool NursingScienceSolidSouth AsianSpecial Populations ResearchSubstance abuse problemTechnologyTherapeutic InterventionTrainingTranslational ResearchUniversitiesVisionWorkforce Developmentanalytical toolbasebiomarker discoverycareer developmentcatalystclinical careclinical databaseclinical investigationcognitive neurosciencecohesioncommunity based researchcommunity engagementdisease heterogeneityethnic diversityethnic minority populationexperiencefollower of religion Jewishimprovedindustry partnerinnovationinterdisciplinary approachlogarithmmedical schoolsmembernatural languagenext generationnovelnovel strategiespopulation healthpreventive interventionprogramsracial diversityracial minorityrecruitrelating to nervous systemresearch clinical testingresponsesevere mental illnessskillssuccesstooltranslational scientisttreatment responsetrial design

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SUMMARY The COVID-19 pandemic disproportionately impacts members of under-represented minority (URM) communi- ties. Unfortunately, URM and other vulnerable communities remain profoundly under-tested. As such, new ap- proaches are needed to disseminate and accomplish testing that could be generalized across the US. New Jersey can serve as a unique, virtual testing laboratory, ranking 11th in the US in population, 2nd in the US (after NY) in the per capita rate of COVID-19 deaths, and 5th in total cases and represents a highly diverse state with substantial Black and Latinx minority populations. At Rutgers, we have assembled cohorts of healthcare workers (HCWs) to monitor the spread of COVID-19 and to enroll subjects for clinical and vaccine trials. While building our cohorts, we recognized many URMs serve as HCWs or personal care aides often in lower-income roles. Further, we also found these workers were more often infected compared with those with higher income occupations. Given these observations, we posit that HCWs in occupations at lower incomes would facilitate testing among their house- holds and their communities. In a sense, these HCWs can serve as ambassadors to catalyze community-based COVID-19 testing. NJ HEROES TOO (New Jersey Healthcare Essential WoRker Outreach and Education Study - Testing Overlooked Occupations) proposes to approach URM HCWs who we have identified as index individu- als who will act as ambassadors to help expand testing in their households and extended networks. In Aim 1, we will co-design, develop and implement an innovative, HCW-centric outreach intervention strategy to engage Black and Latinx minority communities. We will explore community perceptions about COVID-19 testing, treatment, and vaccination to design COVID-19 testing materials and messages that are culturally tailored to address concerns of Black and Latinx minority communities. In Aim 2, we will conduct a mixed methods study to evaluate the effec- tiveness and cost of: (1) the HCW-focused outreach intervention strategy versus (2) standard community engaged outreach, working with community based organizations (CBOs). We will explore contextual factors (individual, family, and community) affecting COVID-19 testing implementation outcomes and scalability. The primary out- come will be uptake of COVID-19 testing in the targeted populations. We propose testing with the novel Rutgers Clinical Genomics Laboratory/RUCDR saliva test, the first FDA-authorized diagnostic test using saliva to detect SARS-CoV-2 for non-invasive, home based self-testing. We hypothesize that a participatory outreach strategy approach focused on identified index HCWs will mobilize quicker uptake of testing within community settings than best-practice CBO recruitment approaches. We also hypothesize that recruitment through index HCWs will be more successful for hard to reach participants compared to a traditional CBO approach. The strategy focusing on HCWs could easily be expanded to other front-line and essential workers, making the strategy generalizable and sustainable.
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New Jersey Alliance for Clinical Translational Science: NJ ACTS
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