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Radiochemistry Core

放射化学核心

基本信息

批准号：
10201546
负责人：
ROBERT H MACH
金额：
$ 36.93万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10201546
关键词：
Blood specimen Carbon Dioxide Clinical Clinical Investigator Cyclotrons Data Analyses Doctor of Philosophy Documentation Drug Addiction Drug Kinetics Ensure Equipment Equipment and supply inventories Fluorides Funding Goals High Pressure Liquid Chromatography Human Resources Image Institution Intervention Investigational Drugs Laboratories Laboratory Personnel Literature Maintenance Measurement NOS2A gene National Institute of Drug Abuse Neurobiology Pilot Projects Positron-Emission Tomography Procedures Process Production Quality Control Radiochemistry Radioisotopes Radiolabeled Radiopharmaceuticals Reactive Oxygen Species Reporting Research Research Personnel Resource Sharing Review Committee Schedule Science Source Testing Training Universities Validation Work addiction carfentanil cohort data modeling delta opioid receptor experience imaging study kappa opioid receptors mu opioid receptors neuroinflammation operation opioid use disorder physiologic model radiotracer ranpirnase

项目摘要

RADIOCHEMISTRY CORE The main function of the Radiochemistry Core is to conduct the Good Manufacturing Procedures (GMP) synthesis of all radiotracers needed to conduct the research in support of the pilot projects. The core will be directed by Robert H. Mach, Ph.D. Dr. Mach is the Director of the Penn Cyclotron Facility and has over thirty years of experience in the field of PET radiochemistry. Hsiaoju Lee, Ph.D., the Penn Cyclotron Facility Manager, will oversee the day-to-day operation of the facility. She has over ten years of experience in the GMP production of PET radiotracers and has worked closely with Dr. Mach for the past 5 years. An addition to this revised application is the involvement of Yale University in this P30 Center; the P.I. of the radiochemistry component for the Yale PET Center is Dr. Yiyun (Henry) Huang, who developed the kappa radiotracer used in this P30 Center. In addition to the GMP production of PET radiotracers, the Radiochemistry Core will be responsible for the synthesis of all precursors and HPLC standards that are required for the research described in the pilot projects that are not available from commercial sources. As part of the Resource Sharing Plan for this P30 Center, these proprietary precursors and standards will be shared with NIDA-funded investigators outside of Penn as a means of accelerating PET imaging research on the neurobiology of opiate use disorders and neuroinflammation. A final function of the Radiochemistry Core is to conduct the metabolite analysis of arterial blood samples from the PET imaging studies that is required for input function measurements by the data analysis group (directed by Dr. Richard Carson, Yale University PET Center).

放射化学核心放射化学核心的主要功能是执行良好生产程序（GMP）综合开展支持试点项目的研究所需的所有放射性示踪剂。芯会导演：Robert H.马赫博士马赫博士是宾州回旋加速器设施的主任，在PET放射化学领域有多年的经验。Hsiaoju Lee，博士，宾州回旋加速器设备经理，将监督该设施的日常运作。她有十多年的GMP生产经验在过去的5年里，他一直与马赫博士密切合作。除此之外，经修订的申请是耶鲁大学在这个P30中心的参与; P.I.放射化学成分， Yiyun（亨利）Huang博士是耶鲁PET中心的负责人，他开发了P30中心使用的Kappa放射性示踪剂。除了PET放射性示踪剂的GMP生产外，放射化学中心还将负责合成试点项目中所述研究所需的所有前体和HPLC标准品这是商业来源所不能提供的。作为P30中心资源共享计划的一部分，专有的前体和标准将与宾夕法尼亚大学以外的NIDA资助的研究人员共享，加速阿片类药物使用障碍和神经炎症的神经生物学PET成像研究。一放射化学核心的最终功能是对动脉血液样本进行代谢物分析数据分析组（由博士理查德卡森，耶鲁大学PET中心）。