Radiochemistry Core

放射化学核心

基本信息

批准号：
10449223
负责人：
ROBERT H MACH
金额：
$ 41.95万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10449223
关键词：
Blood specimen Carbon Dioxide Clinical Clinical Investigator Cyclotrons Data Analyses Doctor of Philosophy Documentation Drug Addiction Drug Kinetics Ensure Equipment Equipment and supply inventories Fluorides Funding Goals High Pressure Liquid Chromatography Human Resources Image Institution Intervention Investigational Drugs Laboratories Laboratory Personnel Literature Maintenance Measurement NOS2A gene National Institute of Drug Abuse Neurobiology Pilot Projects Positron-Emission Tomography Procedures Process Production Quality Control Radiochemistry Radioisotopes Radiolabeled Radiopharmaceuticals Reactive Oxygen Species Reporting Research Research Personnel Resource Sharing Review Committee Schedule Science Source Testing Training Universities Validation Work addiction carfentanil cohort data modeling delta opioid receptor experience imaging study kappa opioid receptors mu opioid receptors neuroinflammation operation opioid use disorder physiologic model radiotracer ranpirnase

项目摘要

RADIOCHEMISTRY CORE The main function of the Radiochemistry Core is to conduct the Good Manufacturing Procedures (GMP) synthesis of all radiotracers needed to conduct the research in support of the pilot projects. The core will be directed by Robert H. Mach, Ph.D. Dr. Mach is the Director of the Penn Cyclotron Facility and has over thirty years of experience in the field of PET radiochemistry. Hsiaoju Lee, Ph.D., the Penn Cyclotron Facility Manager, will oversee the day-to-day operation of the facility. She has over ten years of experience in the GMP production of PET radiotracers and has worked closely with Dr. Mach for the past 5 years. An addition to this revised application is the involvement of Yale University in this P30 Center; the P.I. of the radiochemistry component for the Yale PET Center is Dr. Yiyun (Henry) Huang, who developed the kappa radiotracer used in this P30 Center. In addition to the GMP production of PET radiotracers, the Radiochemistry Core will be responsible for the synthesis of all precursors and HPLC standards that are required for the research described in the pilot projects that are not available from commercial sources. As part of the Resource Sharing Plan for this P30 Center, these proprietary precursors and standards will be shared with NIDA-funded investigators outside of Penn as a means of accelerating PET imaging research on the neurobiology of opiate use disorders and neuroinflammation. A final function of the Radiochemistry Core is to conduct the metabolite analysis of arterial blood samples from the PET imaging studies that is required for input function measurements by the data analysis group (directed by Dr. Richard Carson, Yale University PET Center).

放射化学核心放射化学核心的主要功能是进行良好的制造程序（GMP）需要进行研究以支持试点项目所需的所有放射性示例的综合。核心将是罗伯特·H·马赫（Robert H. Mach）执导Mach博士是Penn Cyclotron设施的主任，拥有三十多个在宠物放射化学领域的多年经验。 Penn Cyclotron设施经理Hsiaoju Lee博士，将监督设施的日常运营。她在GMP生产方面拥有超过十年的经验在过去的5年中，宠物放射性示踪剂与Mach博士密切合作。此修订的补充申请是耶鲁大学在这个P30中心的参与； P.I.放射化学组件的耶鲁宠物中心是Yiyun（Henry）Huang博士，他开发了该P30中心使用的Kappa Radiotracer。除了GMP生产PET辐射示例外，放射化学核心还将负责飞行员项目中描述的研究所需的所有前体和HPLC标准的综合商业来源无法获得。作为该P30中心的资源共享计划的一部分，这些专有的前体和标准将与宾夕法尼亚州以外的NIDA资助的调查员共享加速宠物成像研究有关鸦片使用障碍和神经炎症的神经生物学的研究。一个放射化学核心的最终功能是对来自数据分析组的输入功能测量所需的PET成像研究（由理查德·卡森（Richard Carson）博士，耶鲁大学宠物中心）。