Administrative Core

行政核心 该U19中心的行政核心将负责协调所有相关活动 使用CW2IP2。这将包括安排两周一次的中心执行指导电话 委员会和每月与临床核心成员的联合电话会议。行政核心意志 还组织召开每两年举行一次的对外联络委员会电话会议和年会。这个 管理核心将提供所需的监督，以指导CW2IP在 在日常工作的基础上，例如在参与 财团。行政核心还将对U19中心进行财务监督。其核心是 将由罗伯特·H·马赫博士指导，他是U19中心申请的主任。 鉴于药物化学和放射化学(MCRC)核心的多站点结构，一个关键 行政核心的组成部分是中心执行指导委员会，该委员会由 MCRC核心的现场P.I.S。执行指导委员会将通过视频电话会议就 每两周提供化合物筛选和药物化学研究的最新情况。这个 执行指导委员会将负责确定哪些化合物被确定为HITS将 在结构-活性关系研究中被选作全面评估。双周刊的另一项功能 电话会议是为了审查即将到来的里程碑，并确定U19中心项目是否走上正轨 为实现里程碑而努力。行政核心还将负责获取法规 批准用于首例人体研究翻译的PET放射性示踪剂。

ADMINISTRATIVE CORE The Administrative Core of this U19 Center will be responsible for coordinating all activities associated with the CW2IP2. This will include the scheduling of the biweekly calls of the Center Executive Steering Committee and the monthly joint call with the members of the Clinical Core. The Administrative Core will also organize the bi-annual conference call and annual meeting of the External Liaison Committee. The Administrative Core will provide the oversight needed to direct the efficient operation of the CW2IP on a day-to-day basis, such as the shipment of research materials between the different labs involved in the consortium. The Administrative Core will also provide financial oversight of the U19 Center. The core will be directed by Robert H. Mach, Ph.D. the Director of this U19 Center application. Given the multi-site structure of the Medicinal Chemistry and Radiochemistry (MCRC) Core, a key component of the Administrative Core is the Center Executive Steering Committee, which consists of the site P.I.s of the MCRC core. The Executive Steering Committee will meet via video teleconference on a biweekly basis to provide updates on the compound screening and medicinal chemistry studies. The Executive Steering Committee will be responsible for identifying which compounds identified as hits will be chosen for full evaluation in structure-activity relationship studies. Another function of the biweekly conference calls is to review upcoming milestones, and to determine if the U19 Center project is on track for achieving the milestones. The Administrative Core will also be responsible for the obtaining regulatory approval for the PET radiotracers chosen for translation for first-in-human studies.