Administrative Core

行政核心 该U19中心的行政核心将负责协调所有相关活动 关于CW 2 IP 2这将包括安排中心执行指导的每两周一次的电话会议 委员会和每月与临床核心成员的联合电话会议。行政核心将 并组织一年两次的对外联络委员会电话会议和年会。的 行政核心将提供必要的监督，以指导CW 2 IP的有效运作， 日常的基础上，如运输的研究材料之间的不同实验室参与 财团行政核心还将提供U19中心的财务监督。核心 将由罗伯特·H。马赫博士U19中心申请的主任 鉴于药物化学和放射化学（MCRC）核心的多位点结构， 行政核心的组成部分是中心执行指导委员会，由 MCRC核心的现场PI执行指导委员会将通过视频会议举行会议， 每两周一次，提供化合物筛选和药物化学研究的最新情况。的 执行指导委员会将负责确定哪些化合物被确定为命中， 在结构-活性关系研究中被选择用于全面评价。双周刊的另一个功能 电话会议是为了审查即将到来的里程碑，并确定U19中心项目是否在轨道上 实现里程碑。行政核心还将负责获得监管 批准选择用于首次人体研究的PET放射性示踪剂。

ADMINISTRATIVE CORE The Administrative Core of this U19 Center will be responsible for coordinating all activities associated with the CW2IP2. This will include the scheduling of the biweekly calls of the Center Executive Steering Committee and the monthly joint call with the members of the Clinical Core. The Administrative Core will also organize the bi-annual conference call and annual meeting of the External Liaison Committee. The Administrative Core will provide the oversight needed to direct the efficient operation of the CW2IP on a day-to-day basis, such as the shipment of research materials between the different labs involved in the consortium. The Administrative Core will also provide financial oversight of the U19 Center. The core will be directed by Robert H. Mach, Ph.D. the Director of this U19 Center application. Given the multi-site structure of the Medicinal Chemistry and Radiochemistry (MCRC) Core, a key component of the Administrative Core is the Center Executive Steering Committee, which consists of the site P.I.s of the MCRC core. The Executive Steering Committee will meet via video teleconference on a biweekly basis to provide updates on the compound screening and medicinal chemistry studies. The Executive Steering Committee will be responsible for identifying which compounds identified as hits will be chosen for full evaluation in structure-activity relationship studies. Another function of the biweekly conference calls is to review upcoming milestones, and to determine if the U19 Center project is on track for achieving the milestones. The Administrative Core will also be responsible for the obtaining regulatory approval for the PET radiotracers chosen for translation for first-in-human studies.