Designed Vehicles for Blood Brain Barrier Traversal

设计用于穿越血脑屏障的车辆

基本信息

  • 批准号:
    10200639
  • 负责人:
  • 金额:
    $ 51.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-15 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Emerging peptide-, protein-, and nucleic acid-based therapeutics for the treatment of Alzheimer’s disease and other neurologic conditions are blocked from diffusing into the brain by the blood–brain barrier (BBB). The long-term goal of this project is to deliver large therapeutic cargo such as these into the brain using designed BBB-crossing drug-delivery vehicles. The ​overall objectives are to (i) leverage recent breakthroughs in computational peptide design to yield new knowledge about BBB permeability and (ii) to designed from scratch new proteins that ferry cargo into the brain by exploiting natural systems that the brain uses to receive nutrients and signals. The ​central hypothesis is that the systematic design of functional biomolecules will yield new insights and tools for improving the delivery of large biomolecule therapeutics into the brain. The ​specific aims are: 1) to systematically and rationally discover the physiochemical properties which confer BBB permeability to designed peptide macrocycles (a promising new class of therapeutics); 2) to computationally design small, hyperstable proteins which bind to receptors that naturally cycle between the blood- and brain-side of the BBB; and 3) to fuse the binding proteins generated in Aim 2 to various drug-binding/packaging proteins, thereby creating protein assemblies that ferry large therapeutics into the brain. This project is ​innovative because it proposes to resolve a long-standing barrier to the treatment of neurologic diseases (namely, the difficulty of delivering therapeutics into the brain) by designing from scratch new BBB-crossing drug delivery vehicles. The project is ​significant because it is expected to provide tools which will improve outcomes in a range of future clinical trials of therapeutics which require delivery into the brain.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DAVID BAKER其他文献

DAVID BAKER的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DAVID BAKER', 18)}}的其他基金

De Novo Design of Minibinder Antagonists for COVID-19 and Future Pandemics
针对 COVID-19 和未来大流行病的 Minibinder 拮抗剂的从头设计
  • 批准号:
    10296596
  • 财政年份:
    2021
  • 资助金额:
    $ 51.78万
  • 项目类别:
De Novo Design of Minibinder Antagonists for COVID-19 and Future Pandemics
针对 COVID-19 和未来大流行病的 Minibinder 拮抗剂的从头设计
  • 批准号:
    10460648
  • 财政年份:
    2021
  • 资助金额:
    $ 51.78万
  • 项目类别:
De Novo Design of Minibinder Antagonists for COVID-19 and Future Pandemics
针对 COVID-19 和未来大流行病的 Minibinder 拮抗剂的从头设计
  • 批准号:
    10672446
  • 财政年份:
    2021
  • 资助金额:
    $ 51.78万
  • 项目类别:
Project 4: Novel reagent development to enable molecular characterization
项目 4:开发新型试剂以实现分子表征
  • 批准号:
    10359195
  • 财政年份:
    2020
  • 资助金额:
    $ 51.78万
  • 项目类别:
Project 4: Novel reagent development to enable molecular characterization
项目 4:开发新型试剂以实现分子表征
  • 批准号:
    10573273
  • 财政年份:
    2020
  • 资助金额:
    $ 51.78万
  • 项目类别:
Designed Vehicles for Blood Brain Barrier Traversal
设计用于穿越血脑屏障的车辆
  • 批准号:
    10400878
  • 财政年份:
    2019
  • 资助金额:
    $ 51.78万
  • 项目类别:
Design of de novo interleukin mimics for targeted immunotherapy
用于靶向免疫治疗的从头白细胞介素模拟物的设计
  • 批准号:
    9796930
  • 财政年份:
    2019
  • 资助金额:
    $ 51.78万
  • 项目类别:
Designed Vehicles for Blood Brain Barrier Traversal
设计用于穿越血脑屏障的车辆
  • 批准号:
    10614470
  • 财政年份:
    2019
  • 资助金额:
    $ 51.78万
  • 项目类别:
Design of de novo interleukin mimics for targeted immunotherapy
用于靶向免疫治疗的从头白细胞介素模拟物的设计
  • 批准号:
    10475003
  • 财政年份:
    2019
  • 资助金额:
    $ 51.78万
  • 项目类别:
Designed Vehicles for Blood Brain Barrier Traversal
设计用于穿越血脑屏障的车辆
  • 批准号:
    9796948
  • 财政年份:
    2019
  • 资助金额:
    $ 51.78万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了