A Behavioral Intervention to Engage Emerging Adults in Addiction Treatment after a Non-fatal Opioid Overdose

在非致命性阿片类药物过量后让新兴成年人接受成瘾治疗的行为干预

• 批准号: 10201537
• 负责人: Sarah M Bagley
• 金额: $ 18.01万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201537
• 关键词: Accident and Emergency department; Address; Adult; Aftercare; Age; Area; Behavior Therapy; Behavioral Model; Characteristics; Clinical Trials Design; Conduct Clinical Trials; Development; Event; Family member; Foundations; Future; Goals; Grant; Health Services Accessibility; Healthcare; Heroin; High Prevalence; Individual; Internal Medicine; Intervention; Intervention Trial; Interview; Investigation; Learning; Length; Logistics; Massachusetts; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Modeling; Motivation; Opioid Analgesics; Overdose; Participant; Pediatrics; Population; Positioning Attribute; Public Health; Qualitative Methods; Randomized; Randomized Controlled Trials; Recording of previous events; Recurrence; Research Personnel; Research Training; Retrospective cohort study; Risk; Risk Behaviors; Risk Factors; Risk-Taking; Science; Self Efficacy; Target Populations; Testing; Time; Training; United States; United States National Institutes of Health; Work; acceptability and feasibility; addiction; aged; base; behavior change; career; career development; efficacy testing; efficacy trial; emerging adult; emerging adulthood; experience; field study; follow-up; health data; high risk; high risk behavior; improved; informant; intervention refinement; motivational intervention; opioid epidemic; opioid misuse; opioid mortality; opioid overdose; opioid use; opioid use disorder; outreach; overdose death; overdose risk; patient oriented; pilot trial; prescription opioid; prescription opioid misuse; primary outcome; recruit; substance use; supportive environment; therapy development

PROJECT SUMMARY Opioid-related overdose deaths continue to climb at alarming rates – greater than 200% since 2000. Emerging adults (individuals aged 18-25 years old) are a key demographic in the opioid epidemic, and especially important to engage in treatment, as they account for increasingly high absolute and relative rates of fatal opioid overdoses. Emerging adulthood is a distinct developmental stage and so these treatment engagement efforts should be developmentally tailored. This application describes a 5-year patient-oriented mentored research and training plan to develop a behavioral intervention focused on engagement of high risk emerging adults to treatment after they present to the emergency department with a nonfatal overdose. The proposed intervention model is based on a motivational intervention to reduce overdose risk by improving self-efficacy in adults who have a history of recent nonmedical use of opioid analgesics. My career goal is to become an independent clinician investigator with an expertise in behavioral intervention development and testing for emerging adults with opioid use disorders. The specific aims of this application are to 1) quantify the time to addiction treatment or recurrent overdose for emerging adults who experience a nonfatal overdose, 2) use qualitative methods to inform intervention development for emerging adults who experience a nonfatal overdose, and 3) conduct a pilot trial to determine feasibility and logistics of the intervention. My educational objectives are to learn: 1) behavioral intervention development, 2) science of behavior change in emerging adults, and 3) clinical trial design. I have identified a well-respected mentoring team and a supportive environment to help me achieve my goals. The results from this work will position me to submit a R01 grant to conduct a fully-powered efficacy trial of an intervention to reduce overdose risk behaviors and increase treatment engagement among emerging adults with non-fatal overdose.

项目总结

项目成果

Integrating substance use care into primary care for adolescents and young adults: Lessons learned.

• DOI: 10.1016/j.jsat.2021.108376
• 发表时间: 2021-10
• 期刊: Journal of substance abuse treatment
• 影响因子: 3.9
• 作者: Bagley SM;Hadland SE;Schoenberger SF;Gai MJ;Topp D;Hallett E;Ashe E;Samet JH;Walley AY
• 通讯作者: Walley AY

Integrating Harm Reduction into Outpatient Opioid Use Disorder Treatment Settings : Harm Reduction in Outpatient Addiction Treatment.

将危害减少纳入门诊阿片类药物使用障碍治疗环境：门诊成瘾治疗的损害减少。

• DOI: 10.1007/s11606-021-06904-4
• 发表时间: 2021-12
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Taylor JL;Johnson S;Cruz R;Gray JR;Schiff D;Bagley SM
• 通讯作者: Bagley SM

Characteristics and Receipt of Medication Treatment Among Young Adults Who Experience a Nonfatal Opioid-Related Overdose.

• DOI: 10.1016/j.annemergmed.2019.07.030
• 发表时间: 2020-01
• 期刊: Annals of emergency medicine
• 影响因子: 6.2
• 作者: Bagley SM;Larochelle MR;Xuan Z;Wang N;Patel A;Bernson D;Silverstein M;Hadland SE;Land T;Samet JH;Walley AY
• 通讯作者: Walley AY