A Behavioral Intervention to Engage Emerging Adults in Addiction Treatment after a Non-fatal Opioid Overdose

项目摘要 与阿片类药物有关的过量死亡继续以惊人的速度攀升-自2000年以来超过200%。新兴 成年人（18-25岁的个体）是阿片类药物流行的关键人群，特别是 重要的是，参与治疗，因为他们占越来越高的绝对和相对死亡率， 阿片类药物过量成年期是一个独特的发展阶段，因此这些治疗参与 应根据发展需要作出努力。此应用程序描述了一个为期5年的以患者为导向的指导 研究和培训计划，以制定行为干预措施，重点是参与高风险新兴 成年人在急诊室接受非致命性药物过量治疗后。拟议 干预模式是基于动机干预，通过提高自我效能， 有近期非医疗使用阿片类镇痛药史的成年人。我的职业目标是成为一名 独立的临床研究人员，在行为干预开发和测试方面具有专业知识， 新出现的阿片类药物使用障碍的成年人。本申请的具体目的是：1）量化时间， 成瘾治疗或经常性过量的新兴成年人谁经历非致命性过量，2）使用 定性方法为经历非致命性疾病的新兴成年人提供干预开发信息 过量，和3）进行试点试验，以确定干预的可行性和后勤。我的教育 目标是学习：1）行为干预的发展，2）新兴的行为改变科学 成人; 3）临床试验设计。我已经确定了一个备受尊敬的指导团队和一个支持 环境帮助我实现目标。这项工作的结果将使我能够提交R 01赠款， 进行一项全面的干预有效性试验，以减少过量风险行为， 非致命性过量的新兴成年人的治疗参与。

PROJECT SUMMARY Opioid-related overdose deaths continue to climb at alarming rates – greater than 200% since 2000. Emerging adults (individuals aged 18-25 years old) are a key demographic in the opioid epidemic, and especially important to engage in treatment, as they account for increasingly high absolute and relative rates of fatal opioid overdoses. Emerging adulthood is a distinct developmental stage and so these treatment engagement efforts should be developmentally tailored. This application describes a 5-year patient-oriented mentored research and training plan to develop a behavioral intervention focused on engagement of high risk emerging adults to treatment after they present to the emergency department with a nonfatal overdose. The proposed intervention model is based on a motivational intervention to reduce overdose risk by improving self-efficacy in adults who have a history of recent nonmedical use of opioid analgesics. My career goal is to become an independent clinician investigator with an expertise in behavioral intervention development and testing for emerging adults with opioid use disorders. The specific aims of this application are to 1) quantify the time to addiction treatment or recurrent overdose for emerging adults who experience a nonfatal overdose, 2) use qualitative methods to inform intervention development for emerging adults who experience a nonfatal overdose, and 3) conduct a pilot trial to determine feasibility and logistics of the intervention. My educational objectives are to learn: 1) behavioral intervention development, 2) science of behavior change in emerging adults, and 3) clinical trial design. I have identified a well-respected mentoring team and a supportive environment to help me achieve my goals. The results from this work will position me to submit a R01 grant to conduct a fully-powered efficacy trial of an intervention to reduce overdose risk behaviors and increase treatment engagement among emerging adults with non-fatal overdose.