Examining Validity and Sensitivity of Pressure-Mediated Reflection Spectroscopy as a measure of fruit and vegetable consumption in a diverse community

检查压力介导反射光谱作为多元化社区水果和蔬菜消费量度的有效性和灵敏度

• 批准号: 10205155
• 负责人: Stephanie Bell Jilcott Pitts
• 金额: $ 68.84万
• 依托单位: EAST CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10205155
• 关键词: Address; African American; Asians; Biological Markers; Biopsy; Blood; Carotenoids; Caucasians; Chronic Disease; Communities; Consumption; Devices; Diet; Dietary Assessment; Dietary Intervention; Dietary intake; Dose; Effectiveness; Effectiveness of Interventions; Ethnic Origin; Ethnic group; Genes; Genetic; Genetic Determinism; Genetic Variation; Genomics; Goals; Gold; Hispanics; Hour; Individual; Intake; Internet; Intervention; Intervention Trial; Juice; Latino; Link; Literature; Longevity; Mass Spectrum Analysis; Measurement; Measures; Mediating; Melanins; Methodology; Methods; Not Hispanic or Latino; Nutrition Policy; Outcome Measure; Participant; Patient Self-Report; Physical activity; Pilot Projects; Placebo Control; Plasma; Policies; Population; Population Heterogeneity; Population Surveillance; Proxy; Public Health; Race; Raman Spectrum Analysis; Randomized Controlled Trials; Recommendation; Reporting; Reproducibility; Research; Risk; Rural; Rural Population; SNP genotyping; Sampling; Signal Transduction; Skin; Spectrum Analysis; Time; United States; United States National Institutes of Health; Validation; Vegetables; base; biomarker validation; community based evaluation; data acquisition; dietary; disadvantaged population; ethnic difference; ethnic diversity; fruits and vegetables; health disparity; improved; individual variation; innovation; insight; lipid metabolism; literacy; mathematical ability; meter; mortality; nutrition; population health; portability; pressure; primary outcome; racial and ethnic; racial diversity; response; surveillance study; treatment group

Project Summary/ Abstract A diet rich in fruits and vegetables (F&Vs) is associated with lower risk of nutrition-related chronic diseases and all-cause mortality. Despite these benefits, the US population under-consumes F&Vs, with particularly low intake in disadvantaged populations. Low F&V intake results in higher rates of nutrition-related chronic disease among disadvantaged populations when compared with more advantaged populations. Detecting and addressing inadequate F&V intake in these populations is needed to reduce such disparities. Yet, there is still no commonly used predictive, objective measure of F&V intake for surveillance or determination of policy or intervention effectiveness. The current objective, “gold standard” marker of F&V intake is blood carotenoid concentration—an expensive, time-intensive, and invasive measurement. Traditional methods of self-reported dietary assessment are imprecise and have diminished utility in rural and disadvantaged populations due to low literacy, numeracy, and internet connectivity. In the past decade, skin carotenoid status assessed by non- invasive resonance Raman spectroscopy (RRS) has emerged as a promising biomarker of F&V intake. Reflection spectroscopy (RS) is an improvement over RRS, offering stronger signals, faster data acquisition, and greater portability in a commercially available device (Veggie Meter, Longevity Link Corporation). However, a hurdle impedes deployment of RS for widespread use: to date, nearly all of the non-invasive skin carotenoid validation has been conducted in non-Hispanic whites, primarily by RRS. Therefore, it is critical to evaluate RS in racially and ethnically diverse populations. The central goal of this proposal is to examine validity and sensitivity of RS-assessed skin carotenoid status as a marker of F&V intake in a racially and ethnically diverse sample of individuals. First, we will examine the association (RS Device Validity) between RS-assessed skin carotenoids and the primary outcomes of objectively-measured plasma carotenoids and self-reported F&V consumption across four diverse groups: African-American/Black, Asian, White, and Hispanic/Latino (n=80/group, 40/group per state, N = 320). Then we will conduct a randomized controlled trial to define the relative skin carotenoid responses (RS Device Sensitivity) across racial-ethnic groups, in comparison with plasma carotenoid responses. We will conduct an 8-week randomized controlled trial of a carotenoid-containing juice intervention [placebo control, low (12 oz.) and high (24 oz.) dose juice (29.7 mg carotenoids or ~1.1 c vegetable equivalents)/12 oz.] across 4 genetically-stratified racial-ethnic groups (n = 30/group*treatment, N = 360). Finally, we will investigate the genetic basis for racial/ethnic group differences in skin carotenoid responses to diet through hypothesis-driven genomic analysis of participants from Aims 1 and 2. The results of this study will prepare RS for mass deployment in population surveillance studies and community-based intervention trials, ultimately leading to more accurate determination of the most effective strategies to reduce health disparities related to low F&V intake in the United States and beyond.

项目摘要/摘要