Using pre-pandemic baseline data in people with and without PTSD to study effects of the COVID-19 pandemic on mental health and brain emotion circuits

项目摘要 2019冠状病毒病（COVID-19）大流行造成了恐惧，压力和情感创伤， 生命的丧失、疾病的蔓延、长期的社会孤立和经济上的不安全。疫情相关 经历可能导致创伤后应激症状（PTSS）和其他心理健康问题， 会加重原有的心理健康状况。神经影像学研究表明PTSS和其他精神疾病 健康症状涉及大脑功能和结构改变引起的情绪失调 情绪回路扩展大流行前PTSD发展的神经影像学研究，该应用程序 建议使用大流行前创伤幸存者的神经成像和行为数据， 随后在大流行之前发展或没有发展PTSD，作为基线， 纵向研究流行病对PTSS的影响以及这些受试者相关的大脑情绪系统。 流行病的情绪体验与，例如，冠状病毒感染、社会隔离和金融 将分析不安全感在流行前与流行期PTSS、其他心理健康 症状，大脑结构和大脑激活恐惧情绪相关的任务。大流行期症状和 还将比较大流行前PTSD与非PTSD组的大脑测量，以测试这些组是否 以相似或不同的方式受到影响。对同一受试者的大流行前与大流行后数据进行比较， 优化解决大流行病如何影响心理健康和大脑功能和结构以及如何 大流行正在影响具有不同的大流行前创伤后应激障碍倾向的人。结果将确定 这一流行病对心理健康和大脑的持续影响，并帮助制定应对其后果的战略。

Project Summary The coronavirus disease 2019 (COVID-19) pandemic has caused fear, stress, and emotional trauma due to loss of lives, widespread sickness, extended social isolation, and financial insecurity. Pandemic-related experiences can lead to post-traumatic stress symptoms (PTSS) and other mental health problems and can exacerbate pre-existing mental health conditions. Neuroimaging studies suggest that PTSS and other mental health symptoms involve emotion dysregulation that emerges from functional and structural alterations of brain emotion circuits. Extending pre-pandemic neuroimaging research on PTSD development, this application proposes to use neuroimaging and behavioral data from adult pre-pandemic trauma survivors, who subsequently developed or did not develop PTSD prior to the pandemic, as baselines from which to longitudinally study pandemic effects on PTSS and associated brain emotion systems in these same subjects. Pandemic emotional experiences associated with, e.g., coronavirus infection, social isolation, and financial insecurity will be analyzed with respect to pre- vs. peri-pandemic changes in PTSS, other mental health symptoms, brain structure, and brain activation to fear emotion related tasks. Peri-pandemic symptoms and brain measures will also be compared in pre-pandemic PTSD vs. non-PTSD groups to test if these groups are being affected in similar or different ways. Comparison of pre- vs. peri- pandemic data in the same subjects will optimize resolution of how the pandemic is affecting mental health and brain function and structure and of how the pandemic is affecting people with different pre-pandemic PTSD dispositions. The results will identify ongoing mental health and brain effects of this pandemic and help prepare strategies to deal with its aftermath.