Study of early brain alterations that predict development of chronic PTSD
预测慢性创伤后应激障碍(PTSD)发展的早期大脑改变的研究
基本信息
- 批准号:10337146
- 负责人:
- 金额:$ 29.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-28 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:Accident and Emergency departmentAdministrative SupplementAreaBrainCOVID-19 pandemicChronic Post Traumatic Stress DisorderConsentCountyData AnalysesData CollectionDevelopmentDiagnosisDiagnosticEmotionsFundingGrantGuidelinesHumanHuman ResourcesInterviewInvestmentsMagnetic Resonance ImagingNational Institute of Mental HealthPatientsPost-Traumatic Stress DisordersPriceProceduresProtocols documentationResearchResearch DesignResearch PersonnelRiskSamplingSurveysSurvivorsSymptomsTelephoneTimeTraumaTraumatic Brain InjuryUnited States National Institutes of HealthUniversitiesWorkcostexperienceneuroimagingpandemic diseasepersonal protective equipmentpost-traumarecruitvirtual
项目摘要
Project Summary
Traumatic experience leads to development of posttraumatic stress disorder (PTSD) in some, but not all,
trauma survivors. The funded R01 grant is focused on identifying human brain emotion circuit changes within
early post-trauma weeks that predict subsequent PTSD versus non-PTSD diagnosis in the months-years after
trauma (Specific Aim 1). The grant further examines progressive changes in brain emotion circuits that
associate with PTSD symptom progression from weeks to a year after the trauma (Specific Aim 2). The
approved study design requires recruiting 283 traumatized patients from Emergency Departments (EDs) to
provide longitudinal sampling over a year in 144 subjects, about 35% (50 subjects) of which will likely develop
PTSD. Study recruiting and longitudinal retention progressed as planned over the initial 3.7 years until the
COVID-19 pandemic forestalled recruitment and reduced retention after March 2020 during year 4. Due to
federal, state, county, and University of Toledo mandatory guidelines, the research team has had to modify
protocols in attempts to maintain progress. Modified procedures include e.g., consent over the phone, online
surveys and virtual diagnostic interviews, disinfecting study areas frequently, and providing MRI compatible
personal protection equipment (PPE) to study personnel and subjects. Pandemic disruptions have also
required increased efforts in subject recruitment and retention. Procedural changes are gradually allowing us to
resume the study and have been effective in protecting subjects and researchers. However, this is at the price
of unavoidable, unanticipated slow-downs and costs. To complete the proposed sampling and final data
analyses, this requested Administrative Supplement will underwrite these unexpected costs and is critical for
completing the originally planned work.
项目概要
创伤经历会导致某些人(但不是全部)出现创伤后应激障碍(PTSD),
创伤幸存者。 R01 资助的重点是识别人脑情感回路的变化
创伤后早期几周可预测随后数月或数年内的 PTSD 与非 PTSD 诊断
创伤(具体目标 1)。该资助进一步研究了大脑情绪回路的渐进性变化,
与创伤后数周至一年的 PTSD 症状进展相关(具体目标 2)。这
批准的研究设计需要从急诊科 (ED) 招募 283 名遭受创伤的患者
对 144 名受试者进行一年多的纵向抽样,其中约 35%(50 名受试者)可能会出现
创伤后应激障碍。研究招募和纵向保留在最初的 3.7 年里按计划进行,直到
2020 年 3 月之后的第 4 年,COVID-19 大流行阻止了招聘并减少了保留率。
联邦、州、县和托莱多大学的强制性指南,研究小组不得不修改
协议试图保持进展。修改后的程序包括例如通过电话、在线同意
调查和虚拟诊断访谈,经常消毒研究区域,并提供 MRI 兼容
研究人员和受试者的个人防护装备(PPE)。大流行病也造成了干扰
需要在受试者招募和保留方面加大力度。程序上的改变逐渐使我们能够
恢复研究并有效保护受试者和研究人员。不过,这是按价格计算的
不可避免的、不可预见的放缓和成本。完成建议的抽样和最终数据
分析认为,所要求的行政补充文件将承担这些意外费用,并且对于
完成原定计划的工作。
项目成果
期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Emotion Dysregulation Prospectively Predicts Posttraumatic Stress Disorder Symptom Severity 3 Months After Trauma Exposure.
- DOI:10.1002/jts.22551
- 发表时间:2020-12
- 期刊:
- 影响因子:3.3
- 作者:Forbes, Courtney N;Tull, Matthew T;Rapport, Daniel;Xie, Hong;Kaminski, Brian;Wang, Xin
- 通讯作者:Wang, Xin
Fear of pain as a predictor of concurrent and downstream PTSD symptoms.
- DOI:10.1016/j.janxdis.2021.102441
- 发表时间:2021-08
- 期刊:
- 影响因子:10.3
- 作者:Barbano AC;Tull MT;Christ NM;Xie H;Kaminski B;Wang X
- 通讯作者:Wang X
Adverse childhood experiences associate with early post-trauma thalamus and thalamic nuclei volumes and PTSD development in adulthood.
- DOI:10.1016/j.pscychresns.2021.111421
- 发表时间:2022-01
- 期刊:
- 影响因子:0
- 作者:Xie H;Huffman N;Shih CH;Cotton AS;Buehler M;Brickman KR;Wall JT;Wang X
- 通讯作者:Wang X
Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.
- DOI:10.1007/s11682-020-00423-2
- 发表时间:2021-04
- 期刊:
- 影响因子:3.2
- 作者:Tate DF;Dennis EL;Adams JT;Adamson MM;Belanger HG;Bigler ED;Bouchard HC;Clark AL;Delano-Wood LM;Disner SG;Eapen BC;Franz CE;Geuze E;Goodrich-Hunsaker NJ;Han K;Hayes JP;Hinds SR 2nd;Hodges CB;Hovenden ES;Irimia A;Kenney K;Koerte IK;Kremen WS;Levin HS;Lindsey HM;Morey RA;Newsome MR;Ollinger J;Pugh MJ;Scheibel RS;Shenton ME;Sullivan DR;Taylor BA;Troyanskaya M;Velez C;Wade BS;Wang X;Ware AL;Zafonte R;Thompson PM;Wilde EA
- 通讯作者:Wilde EA
Early self-reported post-traumatic stress symptoms after trauma exposure and associations with diagnosis of post-traumatic stress disorder at 3 months: latent profile analysis.
- DOI:10.1192/bjo.2023.1
- 发表时间:2023-01-26
- 期刊:
- 影响因子:5.4
- 作者:Shih, Chia-Hao;Zhou, Adrian;Grider, Stephen;Xie, Hong;Wang, Xin;Elhai, Jon D.
- 通讯作者:Elhai, Jon D.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Xin Wang其他文献
CD44-engineered mesoporous silica nanoparticles for overcoming multidrug resistance in breast cancer
CD44 工程介孔二氧化硅纳米粒子用于克服乳腺癌的多药耐药性
- DOI:
10.1016/j.apsusc.2015.01.204 - 发表时间:
2015-03 - 期刊:
- 影响因子:0
- 作者:
Xin Wang;Ying Liu;Shouju Wang;Donghong Shi;Xianguang Zhou;Chunyan Wang;Jiang Wu;Zhiyong Zeng;Yanjun Li;Jing Sun;Ji;ong Wang;Longjiang Zhang;Zhaogang Teng;Guangming Lu - 通讯作者:
Guangming Lu
Xin Wang的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Xin Wang', 18)}}的其他基金
Racial/ethnic disparities in acute myeloid leukemia survival in the novel therapy era: an exploration of the underlying mechanisms and potential targets for intervention
新疗法时代急性髓系白血病生存的种族/民族差异:探索潜在机制和潜在干预目标
- 批准号:
10751435 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
N-acetylserotonin alleviates neurotoxicity in alcohol misuse following TBI
N-乙酰血清素可减轻 TBI 后酒精滥用造成的神经毒性
- 批准号:
10591834 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
A large sample machine learning network analysis of vertex cortical thickness measures for high resolution definition of PTSD related cortical structure abnormalities
大样本机器学习网络分析顶点皮质厚度测量,以高分辨率定义 PTSD 相关皮质结构异常
- 批准号:
10373650 - 财政年份:2022
- 资助金额:
$ 29.37万 - 项目类别:
A large sample machine learning network analysis of vertex cortical thickness measures for high resolution definition of PTSD related cortical structure abnormalities
大样本机器学习网络分析顶点皮质厚度测量,以高分辨率定义 PTSD 相关皮质结构异常
- 批准号:
10551850 - 财政年份:2022
- 资助金额:
$ 29.37万 - 项目类别:
Using pre-pandemic baseline data in people with and without PTSD to study effects of the COVID-19 pandemic on mental health and brain emotion circuits
使用患有和不患有 PTSD 的人的大流行前基线数据来研究 COVID-19 大流行对心理健康和大脑情绪回路的影响
- 批准号:
10583520 - 财政年份:2022
- 资助金额:
$ 29.37万 - 项目类别:
Using pre-pandemic baseline data in people with and without PTSD to study effects of the COVID-19 pandemic on mental health and brain emotion circuits
使用患有和不患有 PTSD 的人的大流行前基线数据来研究 COVID-19 大流行对心理健康和大脑情绪回路的影响
- 批准号:
10372490 - 财政年份:2022
- 资助金额:
$ 29.37万 - 项目类别:
Study of early brain alterations that predict development of chronic PTSD
预测慢性创伤后应激障碍(PTSD)发展的早期大脑改变的研究
- 批准号:
9405530 - 财政年份:2016
- 资助金额:
$ 29.37万 - 项目类别:
Study of early brain alterations that predict development of chronic PTSD
预测慢性创伤后应激障碍(PTSD)发展的早期大脑改变的研究
- 批准号:
10004715 - 财政年份:2016
- 资助金额:
$ 29.37万 - 项目类别:
Study of early brain alterations that predict development of chronic PTSD
预测慢性创伤后应激障碍(PTSD)发展的早期大脑改变的研究
- 批准号:
9260326 - 财政年份:2016
- 资助金额:
$ 29.37万 - 项目类别:
Longitudinal MRI study of PTSD development from days to weeks after trauma
创伤后数天至数周 PTSD 发展的纵向 MRI 研究
- 批准号:
8641425 - 财政年份:2013
- 资助金额:
$ 29.37万 - 项目类别:
相似海外基金
Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity - Administrative Supplement
质子分泌上皮细胞作为附睾粘膜免疫的关键调节剂 - 行政补充
- 批准号:
10833895 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
A Longitudinal Qualitative Study of Fentanyl-Stimulant Polysubstance Use Among People Experiencing Homelessness (Administrative supplement)
无家可归者使用芬太尼兴奋剂多物质的纵向定性研究(行政补充)
- 批准号:
10841820 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
StrokeNet Administrative Supplement for the Funding Extension
StrokeNet 资助延期行政补充文件
- 批准号:
10850135 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
2023 NINDS Landis Mentorship Award - Administrative Supplement to NS121106 Control of Axon Initial Segment in Epilepsy
2023 年 NINDS 兰迪斯指导奖 - NS121106 癫痫轴突初始段控制的行政补充
- 批准号:
10896844 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
Biomarkers of Disease in Alcoholic Hepatitis Administrative Supplement
酒精性肝炎行政补充剂中疾病的生物标志物
- 批准号:
10840220 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
Administrative Supplement: Life-Space and Activity Digital Markers for Detection of Cognitive Decline in Community-Dwelling Older Adults: The RAMS Study
行政补充:用于检测社区老年人认知衰退的生活空间和活动数字标记:RAMS 研究
- 批准号:
10844667 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
Administrative Supplement: Improving Inference of Genetic Architecture and Selection with African Genomes
行政补充:利用非洲基因组改进遗传结构的推断和选择
- 批准号:
10891050 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
Power-Up Study Administrative Supplement to Promote Diversity
促进多元化的 Power-Up 研究行政补充
- 批准号:
10711717 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
Administrative Supplement for Peer-Delivered and Technology-Assisted Integrated Illness Management and Recovery
同行交付和技术辅助的综合疾病管理和康复的行政补充
- 批准号:
10811292 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别:
Administrative Supplement: Genome Resources for Model Amphibians
行政补充:模型两栖动物基因组资源
- 批准号:
10806365 - 财政年份:2023
- 资助金额:
$ 29.37万 - 项目类别: