Study of early brain alterations that predict development of chronic PTSD

预测慢性创伤后应激障碍（PTSD）发展的早期大脑改变的研究

• 批准号: 10337146
• 负责人: Xin Wang
• 金额: $ 29.37万
• 依托单位: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-28 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10337146
• 关键词: Accident and Emergency department; Administrative Supplement; Area; Brain; COVID-19 pandemic; Chronic Post Traumatic Stress Disorder; Consent; County; Data Analyses; Data Collection; Development; Diagnosis; Diagnostic; Emotions; Funding; Grant; Guidelines; Human; Human Resources; Interview; Investments; Magnetic Resonance Imaging; National Institute of Mental Health; Patients; Post-Traumatic Stress Disorders; Price; Procedures; Protocols documentation; Research; Research Design; Research Personnel; Risk; Sampling; Surveys; Survivors; Symptoms; Telephone; Time; Trauma; Traumatic Brain Injury; United States National Institutes of Health; Universities; Work; cost; experience; neuroimaging; pandemic disease; personal protective equipment; post-trauma; recruit; virtual

Project Summary Traumatic experience leads to development of posttraumatic stress disorder (PTSD) in some, but not all, trauma survivors. The funded R01 grant is focused on identifying human brain emotion circuit changes within early post-trauma weeks that predict subsequent PTSD versus non-PTSD diagnosis in the months-years after trauma (Specific Aim 1). The grant further examines progressive changes in brain emotion circuits that associate with PTSD symptom progression from weeks to a year after the trauma (Specific Aim 2). The approved study design requires recruiting 283 traumatized patients from Emergency Departments (EDs) to provide longitudinal sampling over a year in 144 subjects, about 35% (50 subjects) of which will likely develop PTSD. Study recruiting and longitudinal retention progressed as planned over the initial 3.7 years until the COVID-19 pandemic forestalled recruitment and reduced retention after March 2020 during year 4. Due to federal, state, county, and University of Toledo mandatory guidelines, the research team has had to modify protocols in attempts to maintain progress. Modified procedures include e.g., consent over the phone, online surveys and virtual diagnostic interviews, disinfecting study areas frequently, and providing MRI compatible personal protection equipment (PPE) to study personnel and subjects. Pandemic disruptions have also required increased efforts in subject recruitment and retention. Procedural changes are gradually allowing us to resume the study and have been effective in protecting subjects and researchers. However, this is at the price of unavoidable, unanticipated slow-downs and costs. To complete the proposed sampling and final data analyses, this requested Administrative Supplement will underwrite these unexpected costs and is critical for completing the originally planned work.

项目概要 创伤经历会导致某些人（但不是全部）出现创伤后应激障碍（PTSD）， 创伤幸存者。 R01 资助的重点是识别人脑情感回路的变化 创伤后早期几周可预测随后数月或数年内的 PTSD 与非 PTSD 诊断 创伤（具体目标 1）。该资助进一步研究了大脑情绪回路的渐进性变化， 与创伤后数周至一年的 PTSD 症状进展相关（具体目标 2）。这 批准的研究设计需要从急诊科 (ED) 招募 283 名遭受创伤的患者 对 144 名受试者进行一年多的纵向抽样，其中约 35%（50 名受试者）可能会出现 创伤后应激障碍。研究招募和纵向保留在最初的 3.7 年里按计划进行，直到 2020 年 3 月之后的第 4 年，COVID-19 大流行阻止了招聘并减少了保留率。 联邦、州、县和托莱多大学的强制性指南，研究小组不得不修改 协议试图保持进展。修改后的程序包括例如通过电话、在线同意 调查和虚拟诊断访谈，经常消毒研究区域，并提供 MRI 兼容 研究人员和受试者的个人防护装备（PPE）。大流行病也造成了干扰 需要在受试者招募和保留方面加大力度。程序上的改变逐渐使我们能够 恢复研究并有效保护受试者和研究人员。不过，这是按价格计算的 不可避免的、不可预见的放缓和成本。完成建议的抽样和最终数据 分析认为，所要求的行政补充文件将承担这些意外费用，并且对于 完成原定计划的工作。

项目成果

Emotion Dysregulation Prospectively Predicts Posttraumatic Stress Disorder Symptom Severity 3 Months After Trauma Exposure.

• DOI: 10.1002/jts.22551
• 发表时间: 2020-12
• 期刊: JOURNAL OF TRAUMATIC STRESS
• 影响因子: 3.3
• 作者: Forbes, Courtney N;Tull, Matthew T;Rapport, Daniel;Xie, Hong;Kaminski, Brian;Wang, Xin
• 通讯作者: Wang, Xin

Fear of pain as a predictor of concurrent and downstream PTSD symptoms.

• DOI: 10.1016/j.janxdis.2021.102441
• 发表时间: 2021-08
• 期刊: Journal of anxiety disorders
• 影响因子: 10.3
• 作者: Barbano AC;Tull MT;Christ NM;Xie H;Kaminski B;Wang X
• 通讯作者: Wang X

Adverse childhood experiences associate with early post-trauma thalamus and thalamic nuclei volumes and PTSD development in adulthood.

• DOI: 10.1016/j.pscychresns.2021.111421
• 发表时间: 2022-01
• 期刊: Psychiatry research. Neuroimaging
• 作者: Xie H;Huffman N;Shih CH;Cotton AS;Buehler M;Brickman KR;Wall JT;Wang X
• 通讯作者: Wang X

Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.

• DOI: 10.1007/s11682-020-00423-2
• 发表时间: 2021-04
• 期刊: Brain imaging and behavior
• 影响因子: 3.2
• 作者: Tate DF;Dennis EL;Adams JT;Adamson MM;Belanger HG;Bigler ED;Bouchard HC;Clark AL;Delano-Wood LM;Disner SG;Eapen BC;Franz CE;Geuze E;Goodrich-Hunsaker NJ;Han K;Hayes JP;Hinds SR 2nd;Hodges CB;Hovenden ES;Irimia A;Kenney K;Koerte IK;Kremen WS;Levin HS;Lindsey HM;Morey RA;Newsome MR;Ollinger J;Pugh MJ;Scheibel RS;Shenton ME;Sullivan DR;Taylor BA;Troyanskaya M;Velez C;Wade BS;Wang X;Ware AL;Zafonte R;Thompson PM;Wilde EA
• 通讯作者: Wilde EA

Early self-reported post-traumatic stress symptoms after trauma exposure and associations with diagnosis of post-traumatic stress disorder at 3 months: latent profile analysis.

• DOI: 10.1192/bjo.2023.1
• 发表时间: 2023-01-26
• 期刊: BJPSYCH OPEN
• 影响因子: 5.4
• 作者: Shih, Chia-Hao;Zhou, Adrian;Grider, Stephen;Xie, Hong;Wang, Xin;Elhai, Jon D.
• 通讯作者: Elhai, Jon D.