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Project Summary Traumatic experience leads to development of posttraumatic stress disorder (PTSD) in some, but not all, trauma survivors. The funded R01 grant is focused on identifying human brain emotion circuit changes within early post-trauma weeks that predict subsequent PTSD versus non-PTSD diagnosis in the months-years after trauma (Specific Aim 1). The grant further examines progressive changes in brain emotion circuits that associate with PTSD symptom progression from weeks to a year after the trauma (Specific Aim 2). The approved study design requires recruiting 283 traumatized patients from Emergency Departments (EDs) to provide longitudinal sampling over a year in 144 subjects, about 35% (50 subjects) of which will likely develop PTSD. Study recruiting and longitudinal retention progressed as planned over the initial 3.7 years until the COVID-19 pandemic forestalled recruitment and reduced retention after March 2020 during year 4. Due to federal, state, county, and University of Toledo mandatory guidelines, the research team has had to modify protocols in attempts to maintain progress. Modified procedures include e.g., consent over the phone, online surveys and virtual diagnostic interviews, disinfecting study areas frequently, and providing MRI compatible personal protection equipment (PPE) to study personnel and subjects. Pandemic disruptions have also required increased efforts in subject recruitment and retention. Procedural changes are gradually allowing us to resume the study and have been effective in protecting subjects and researchers. However, this is at the price of unavoidable, unanticipated slow-downs and costs. To complete the proposed sampling and final data analyses, this requested Administrative Supplement will underwrite these unexpected costs and is critical for completing the originally planned work.
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DOI: 10.1002/jts.22551
发表时间: 2020-12
期刊: JOURNAL OF TRAUMATIC STRESS
影响因子: 3.3
作者: [Forbes, Courtney N, Tull, Matthew T, Rapport, Daniel, Xie, Hong, Kaminski, Brian, Wang, Xin]
通讯作者: Wang, Xin
DOI: 10.1016/j.janxdis.2021.102441
发表时间: 2021-08
期刊: Journal of anxiety disorders
影响因子: 10.3
作者: [Barbano AC, Tull MT, Christ NM, Xie H, Kaminski B, Wang X]
通讯作者: Wang X
DOI: 10.1016/j.pscychresns.2021.111421
发表时间: 2022-01
期刊: Psychiatry research. Neuroimaging
影响因子: --
作者: [Xie H, Huffman N, Shih CH, Cotton AS, Buehler M, Brickman KR, Wall JT, Wang X]
通讯作者: Wang X
DOI: 10.1007/s11682-020-00423-2
发表时间: 2021-04
期刊: Brain imaging and behavior
影响因子: 3.2
作者: [Tate DF, Dennis EL, Adams JT, Adamson MM, Belanger HG, Bigler ED, Bouchard HC, Clark AL, Delano-Wood LM, Disner SG, Eapen BC, Franz CE, Geuze E, Goodrich-Hunsaker NJ, Han K, Hayes JP, Hinds SR 2nd, Hodges CB, Hovenden ES, Irimia A, Kenney K, Koerte IK, Kremen WS, Levin HS, Lindsey HM, Morey RA, Newsome MR, Ollinger J, Pugh MJ, Scheibel RS, Shenton ME, Sullivan DR, Taylor BA, Troyanskaya M, Velez C, Wade BS, Wang X, Ware AL, Zafonte R, Thompson PM, Wilde EA]
通讯作者: Wilde EA
17
    N-acetylserotonin alleviates neurotoxicity in alcohol misuse following TBI
    • 批准号:
      10591834
    • 项目类别:
    • 资助金额:
      $23.01万
    • 财政年份:
      2023
    • 负责人:
      Xin Wang
    • 依托单位:
    海外基金