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O-Specific Polysaccharide Responses and Cholera

O-Specific Polysaccharide Responses and Cholera
O 特异性多糖反应和霍乱
批准号：
10372233
负责人：
Edward T. Ryan
金额：
$73.95万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
项目状态：
未结题
起止时间：
2013-08-07 至 2025-03-31
来源：
https://reporter.nih.gov/project-details/10372233
关键词：
5 year oldAddressAffectAntibodiesAntibody ResponseAntigensBangladeshBangladeshiBinding SitesBiopsyCessation of lifeChildCholeraCholera VaccineClinicalClinical ResearchCountryDataDiseaseEcologyEndoscopyEvaluationGenderGeneticGoalsHomingHouseholdHumanImmuneImmune responseImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunologicsIngestionInstitutional Review BoardsInternationalIntestinesLymphocyteMediatingMediator of activation proteinMemory B-LymphocyteMethodsModelingMonoclonal AntibodiesMucinsMucosal Immune ResponsesMucous MembraneNatureO AntigensOralPatientsPeer ReviewPenetrationPlasmablastPopulationPositioning AttributeProtocols documentationPublic HealthPublicationsReagentResourcesSamplingStructureT-LymphocyteTestingTissuesTranslational ResearchVaccinatedVaccinationVaccineeVertebral columnVibrio choleraeVibrio cholerae O1Vibrio cholerae infectionWorkantigen bindingblood groupcell motilitycostdimerexperienceholotoxinshuman monoclonal antibodieshuman subjectimmunogenicimprovedlong term memorynanonovelpathogenprogramsresponsesoundsuccesstranslational medicinevaccination strategyvaccine strategy

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英文摘要
PROJECT SUMMARY Cholera is a severe dehydrating illness of humans. It is endemic in over 50 countries and causes 3 to 5 million cases a year, resulting in approximately 100,000 deaths. Currently available cholera vaccines have shortcomings. They are often poorly immunogenic in children under the age of 5 years, and often do not induce robust long-term memory responses in immunologically naïve populations. We provide strong preliminary data that antibodies targeting O-specific polysaccharide (OSP) affect Vibrio cholerae and are associated with protection against cholera. We here propose an international clinical study approach to investigate the impact of OSP-specific antibodies on V. cholerae and to define OSP-specific immune responses in humans.
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