O 特异性多糖反应和霍乱-猫眼课题宝

O 特异性多糖反应和霍乱

批准号：

10598007

负责人：

Edward T. Ryan

金额：

$73.99万

依托单位：

MASSACHUSETTS GENERAL HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

未结题

起止时间：

2013-08-07 至 2025-03-31

来源：

https://reporter.nih.gov/project-details/10598007

关键词：

5 year old Address Affect Age Antibodies Antibody Response Antigens Bangladesh Bangladeshi Binding Sites Biopsy Blood typing procedure Cessation of life Child Cholera Cholera Vaccine Clinical Clinical Research Country Data Dehydration Disease Ecology Endoscopy Evaluation Gender Genetic Goals Homing Household Human Immune Immune response Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunologics Ingestion Institutional Review Boards International Intestines Lymphocyte Mediating Mediator Memory B-Lymphocyte Methods Modeling Monoclonal Antibodies Mucins Mucosal Immune Responses Mucous Membrane Nature O Antigens Oral Patients Peer Review Penetration Plasmablast Population Positioning Attribute Protocols documentation Public Health Publications Reagent Resources Sampling Structure T-Lymphocyte Testing Tissues Translational Research Vaccinated Vaccination Vaccinee Vertebral column Vibrio cholerae Vibrio cholerae O1 Vibrio cholerae infection Work antigen binding blood group cell motility cost dimer experience holotoxins human monoclonal antibodies human subject immunogenic improved long term memory nano novel pathogen programs response sound success translational medicine vaccination strategy vaccine strategy

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中文摘要

翻译

项目总结霍乱是一种严重的人类脱水疾病。它在50多个国家流行，并导致3 每年有500万个病例，导致大约100,000人死亡。目前可用的霍乱疫苗也有缺点。在5岁以下的儿童中，它们的免疫原性往往很差。在免疫幼稚的情况下，通常不会诱发强大的长期记忆反应人口。我们提供了强有力的初步数据，针对O-特异性多糖的抗体 (OSP)会影响霍乱弧菌，并与预防霍乱有关。我们在这里提出一项国际临床研究方法，以调查OSP特异性抗体对V. 霍乱弧菌，并确定OSP在人类中的特异性免疫反应。

英文摘要

PROJECT SUMMARY Cholera is a severe dehydrating illness of humans. It is endemic in over 50 countries and causes 3 to 5 million cases a year, resulting in approximately 100,000 deaths. Currently available cholera vaccines have shortcomings. They are often poorly immunogenic in children under the age of 5 years, and often do not induce robust long-term memory responses in immunologically naïve populations. We provide strong preliminary data that antibodies targeting O-specific polysaccharide (OSP) affect Vibrio cholerae and are associated with protection against cholera. We here propose an international clinical study approach to investigate the impact of OSP-specific antibodies on V. cholerae and to define OSP-specific immune responses in humans.

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