Administrative Core

行政核心

• 批准号: 10204118
• 负责人: Pamela J Lein
• 金额: $ 27.48万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10204118
• 关键词: Acute; Advanced Development; Advisory Committees; Anticonvulsants; Calendar; Chemicals; Cholinesterase Inhibitors; Collaborations; Committee Members; Communication; Communities; Data; Database Management Systems; Development; Educational workshop; Ensure; Environmental Health; Equipment and supply inventories; Event; Federal Government; Fostering; Funding; General Population; Goals; Government Agencies; Grant; Human Resources; IACUC; Intellectual Property; Intoxication; Investigational Drugs; Isoflurophate; Laboratories; Lead; Leadership; Legal patent; Logistics; Manuscripts; Medical Research; Mission; Monitor; Online Systems; Organophosphates; Paraoxon; Picrotoxin; Policies; Procedures; Protocols documentation; PubMed; Readiness; Reagent; Regulation; Reporting; Research; Research Activity; Research Institute; Research Personnel; Research Project Grants; Resource Sharing; Role; Safety; Secure; Security; Seizures; Series; Soman; Strategic Planning; System; Technology Transfer; Therapeutic; Therapeutic Agents; TimeLine; Training; United States Food and Drug Administration; United States National Institutes of Health; Universities; Work; authority; central database; chemical threat; data exchange; data management; data sharing; education research; improved; interest; medical countermeasure; meetings; novel; operation; prevent; programs; receptor; research and development; statistics; success; synergism; tetramethylenedisulfotetramine; therapeutic development; web site

Project Summary – Administrative Core The overall goal of the UC Davis CounterACT Center of Excellence is to identify and advance improved medical countermeasures for stopping seizures and preventing long-term consequences of acute intoxication with chemical threat agents, specifically organophosphate cholinesterase inhibitors like diisopropylfluorophosphate (DFP), paraoxon and soman, or GABAA receptor blockers like tetramethylenedisulfotetramine (TETS) and picrotoxin. The UC Davis CounterACT Center comprises three projects, three scientific cores, a research education core and multiple committees — all of which must work closely together to ensure success. The role of the Administrative Core is to oversee and coordinate the scientific and administrative operations of the Center's activities and to foster interactions and synergism among Center research projects and scientific cores, ultimately ensuring the Center meets annual milestones established in collaboration with NIH CounterACT program officer(s). Additionally, the Administrative Core will coordinate interactions with the UC Davis administration and external entities, such as the NIH CounterACT administration, the Center's External Advisory Committee, the larger CounterACT research community, the U.S. Food and Drug Administration (FDA), the Biomedical Advanced Research and Development Authority (BARDA), and commercial partners. The Core's objectives are: (1) Develop a strategic plan for achieving annual Center milestones and ensure its effective and efficient implementation; (2) Provide scientific leadership and logistical support to coordinate and integrate Center activities and promote interactions among Center investigators; (3) Facilitate data and resource sharing among Center investigators and other CounterACT investigators; (4) Provide budgetary oversight and grant management; (5) Ensure the safety and security of personnel, materials, data and facilities; (6) Coordinate the development of intellectual property (IP) strategies and the transitioning of leads for advanced development; (7) Coordinate with FDA, BARDA and other federal government agencies; and (8) Identify, engage and coordinate communications with commercial partners.

项目摘要-行政核心 加州大学戴维斯分校CounterACT卓越中心的总体目标是确定和推进改善医疗 制止癫痫发作和预防急性中毒的长期后果的对策 化学威胁剂，特别是有机磷酸胆碱酯酶抑制剂，如二异丙基氟磷酸盐 (DFP)、对氧磷和梭曼，或GABAA受体阻断剂如四亚甲基二磺基四胺（TETS）和 印防己毒素加州大学戴维斯分校反ACT中心包括三个项目，三个科学核心，一个研究 教育核心和多个委员会--所有这些都必须密切合作，以确保成功。的作用 的行政核心是监督和协调科学和行政运作的 中心的活动，并促进中心研究项目和科学核心之间的互动和协同作用， 最终确保中心达到与NIH CounterACT合作建立的年度里程碑 程序员（S）。此外，行政核心将协调与加州大学戴维斯分校的互动 管理和外部实体，如NIH CounterACT管理，中心的外部咨询 委员会，更大的反ACT研究社区，美国食品和药物管理局（FDA）， 生物医学高级研究和发展管理局（巴尔达）和商业合作伙伴。该芯体的 目标是：（1）制定实现中心年度里程碑的战略计划，并确保其有效性和 （2）提供科学的领导和后勤支持，以协调和整合 中心活动，促进中心研究者之间的互动;（3）促进数据和资源共享 （4）提供预算监督和拨款 （五）确保人员、物资、数据和设施的安全;（六）协调 制定知识产权（IP）战略，并为高级开发转移线索;（7） 与FDA、巴尔达和其他联邦政府机构协调;以及（8）识别、参与和协调 与商业伙伴的沟通。