Administrative Core

项目摘要-管理核心 加州大学戴维斯分校卓越对抗中心的总体目标是确定和推进改进的医疗 杜绝癫痫发作及预防急性中毒长期后果的对策 化学威胁物质，特别是有机磷胆碱酯酶抑制剂，如二异丙基氟磷酸盐 (DFP)、对氧磷和梭曼，或GABAA受体阻滞剂，如四亚甲基二磺酸毒鼠强(TETS)和 印防己毒素。加州大学戴维斯分校对抗中心包括三个项目，三个科学核心，一项研究 教育核心和多个委员会--所有这些都必须密切合作，以确保成功。角色 行政核心的职责是监督和协调行政部门的科学和行政运作 中心的活动，并促进中心研究项目和科学核心之间的互动和协同作用， 最终确保中心达到与美国国立卫生研究院合作制定的年度里程碑 项目负责人(S)。此外，管理核心将协调与加州大学戴维斯分校的互动 行政部门和外部实体，如国家卫生研究院的反行政部门、中心的外部咨询 委员会，更大的对抗研究社区，美国食品和药物管理局(FDA)， 生物医学高级研究和发展局(BARDA)和商业合作伙伴。核心的 目标是：(1)制定实现年度中心里程碑的战略计划，并确保其有效和 高效实施；(2)提供科学领导和后勤支持，协调整合 中心活动和促进中心调查人员之间的互动；(3)促进数据和资源共享 在中心调查人员和其他反调查人员中；(4)提供预算监督和拨款 管理；(5)确保人员、材料、数据和设施的安全和保障；(6)协调 制定知识产权战略和过渡高级发展的领导；(7) 与FDA、BARDA和其他联邦政府机构协调；以及(8)确定、接触和协调 与商业合作伙伴的沟通。

Project Summary – Administrative Core The overall goal of the UC Davis CounterACT Center of Excellence is to identify and advance improved medical countermeasures for stopping seizures and preventing long-term consequences of acute intoxication with chemical threat agents, specifically organophosphate cholinesterase inhibitors like diisopropylfluorophosphate (DFP), paraoxon and soman, or GABAA receptor blockers like tetramethylenedisulfotetramine (TETS) and picrotoxin. The UC Davis CounterACT Center comprises three projects, three scientific cores, a research education core and multiple committees — all of which must work closely together to ensure success. The role of the Administrative Core is to oversee and coordinate the scientific and administrative operations of the Center's activities and to foster interactions and synergism among Center research projects and scientific cores, ultimately ensuring the Center meets annual milestones established in collaboration with NIH CounterACT program officer(s). Additionally, the Administrative Core will coordinate interactions with the UC Davis administration and external entities, such as the NIH CounterACT administration, the Center's External Advisory Committee, the larger CounterACT research community, the U.S. Food and Drug Administration (FDA), the Biomedical Advanced Research and Development Authority (BARDA), and commercial partners. The Core's objectives are: (1) Develop a strategic plan for achieving annual Center milestones and ensure its effective and efficient implementation; (2) Provide scientific leadership and logistical support to coordinate and integrate Center activities and promote interactions among Center investigators; (3) Facilitate data and resource sharing among Center investigators and other CounterACT investigators; (4) Provide budgetary oversight and grant management; (5) Ensure the safety and security of personnel, materials, data and facilities; (6) Coordinate the development of intellectual property (IP) strategies and the transitioning of leads for advanced development; (7) Coordinate with FDA, BARDA and other federal government agencies; and (8) Identify, engage and coordinate communications with commercial partners.