Administrative Core

项目摘要-管理核心 新的加州大学戴维斯分校卓越对抗中心的总体目标是确定和推进 开发治疗策略以减轻个体的长期不良神经后果 谁在有机磷(OP)胆碱酯酶急性中毒引发的胆碱能危象中幸存下来 抑制剂。该中心由三个科学项目、三个科学核心、一个研究教育组成 CORE，一个新兴的科学和科学家试点项目计划，以及多个委员会--所有这些都将 紧密合作，确保成功。行政核心将集中协调、沟通 以及项目和核心之间的整合，并促进整个中心的协同作用，最终确保 中心达到了与美国国立卫生研究院对抗计划官员(S)合作建立的年度里程碑。活动 将包括提供全面的科学领导、财政监督和后勤支持以及援助 传播研究成果，鼓励和促进与外部调查人员共享数据。 此外，管理核心将协调中心与加州大学戴维斯分校的管理和 外部实体，如国家卫生研究院抵消行政，中心的外部咨询委员会，较大的 对抗研究社区，美国食品和药物管理局(FDA)，生物医学先进 研究和发展局(BARDA)和潜在的商业合作伙伴。核心的目标是 为：(1)提供科学的领导和后勤支持，协调和整合中心的活动和 促进中心调查人员之间的互动，以达到中心的年度里程碑；(2)管理新出现的 科学和科学家试点项目计划(ESSP3)；(3)促进中心之间的数据和资源共享 调查员和其他反调查员；(4)提供预算监督和赠款管理；(5) 确保人员、材料、数据和设施的安全；(6)追求知识产权(IP) 战略，并确定、接触和协调与商业伙伴的沟通；以及(7)协调 与FDA、BARDA和其他联邦政府机构合作。

Project Summary – Administrative Core The overall objective of the new UC Davis CounterACT Center of Excellence is to identify and advance the development of therapeutic strategies for mitigating long-term, adverse neurologic consequences in individuals who survive the cholinergic crisis triggered by acute intoxication with organophosphate (OP) cholinesterase inhibitors. The Center is comprised of three scientific Projects, three scientific Cores, a Research Education Core, an Emerging Science and Scientists Pilot Project Program, and multiple committees — all of which will work closely together to ensure success. The Administrative Core will centralize coordination, communication and integration among the Projects and Cores and foster synergy across the Center, ultimately ensuring the Center meets annual milestones established in collaboration with NIH CounterACT program officer(s). Activities will include providing overall scientific leadership, fiscal oversight, and logistical support as well as assistance with disseminating research findings and encouraging and facilitating data sharing with external investigators. Additionally, the Administrative Core will coordinate Center interactions with the UC Davis administration and external entities, such as the NIH CounterACT administration, the Center’s External Advisory Board, the larger CounterACT research community, the U.S. Food and Drug Administration (FDA), the Biomedical Advanced Research and Development Authority (BARDA), and potential commercial partners. The Core’s objectives are to: (1) Provide scientific leadership and logistics support to coordinate and integrate Center activities and promote interactions among Center investigators to meet annual Center milestones; (2) Administer the Emerging Science and Scientists Pilot Project Program (ESSP3); (3) Facilitate data and resource sharing among Center investigators and other CounterACT investigators; (4) Provide budgetary oversight and grant management; (5) Ensure the safety and security of personnel, materials, data and facilities; (6) Pursue intellectual property (IP) strategies, and identify, engage and coordinate communications with commercial partners; and (7) Coordinate with FDA, BARDA and other federal government agencies.