Administrative Core

项目摘要-行政核心 新的加州大学戴维斯分校反ACT卓越中心的总体目标是确定和推进 制定治疗策略，以减轻长期的，不良的神经系统后果的个人 在有机磷胆碱酯酶急性中毒引发的胆碱能危象中幸存的人 抑制剂的该中心由三个科学项目，三个科学核心，一个研究教育， 核心，新兴科学和科学家试点项目计划，以及多个委员会-所有这些都将 密切合作，确保成功。行政核心将集中协调、沟通、 项目和核心之间的整合，并促进整个中心的协同作用，最终确保 中心符合与NIH CounterACT项目官员合作建立的年度里程碑。活动 将包括提供全面的科学领导、财政监督、后勤支持和援助 传播研究成果，鼓励和促进与外部调查人员共享数据。 此外，行政核心将协调中心与加州大学戴维斯分校管理部门的互动， 外部实体，如NIH CounterACT管理，中心的外部咨询委员会，更大的 CounterACT研究社区，美国食品和药物管理局（FDA），生物医学高级 研究和发展管理局（巴尔达）和潜在的商业伙伴。核心的目标是 （1）提供科学的领导和后勤支持，以协调和整合中心的活动， 促进中心研究者之间的互动，以实现年度中心里程碑;（2）管理新兴的 科学和科学家试点项目计划（ESSP 3）;（3）促进中心之间的数据和资源共享 （4）对案件进行调查;（5）对案件进行调查;（6）对案件进行调查; 确保人员、材料、数据和设施的安全;（6）追求知识产权（IP） 战略，并确定、参与和协调与商业合作伙伴的沟通;以及（7）协调 与FDA、巴尔达和其他联邦政府机构合作。

Project Summary – Administrative Core The overall objective of the new UC Davis CounterACT Center of Excellence is to identify and advance the development of therapeutic strategies for mitigating long-term, adverse neurologic consequences in individuals who survive the cholinergic crisis triggered by acute intoxication with organophosphate (OP) cholinesterase inhibitors. The Center is comprised of three scientific Projects, three scientific Cores, a Research Education Core, an Emerging Science and Scientists Pilot Project Program, and multiple committees — all of which will work closely together to ensure success. The Administrative Core will centralize coordination, communication and integration among the Projects and Cores and foster synergy across the Center, ultimately ensuring the Center meets annual milestones established in collaboration with NIH CounterACT program officer(s). Activities will include providing overall scientific leadership, fiscal oversight, and logistical support as well as assistance with disseminating research findings and encouraging and facilitating data sharing with external investigators. Additionally, the Administrative Core will coordinate Center interactions with the UC Davis administration and external entities, such as the NIH CounterACT administration, the Center’s External Advisory Board, the larger CounterACT research community, the U.S. Food and Drug Administration (FDA), the Biomedical Advanced Research and Development Authority (BARDA), and potential commercial partners. The Core’s objectives are to: (1) Provide scientific leadership and logistics support to coordinate and integrate Center activities and promote interactions among Center investigators to meet annual Center milestones; (2) Administer the Emerging Science and Scientists Pilot Project Program (ESSP3); (3) Facilitate data and resource sharing among Center investigators and other CounterACT investigators; (4) Provide budgetary oversight and grant management; (5) Ensure the safety and security of personnel, materials, data and facilities; (6) Pursue intellectual property (IP) strategies, and identify, engage and coordinate communications with commercial partners; and (7) Coordinate with FDA, BARDA and other federal government agencies.