Differential Impact of ACEs and Aging on Brain Health
ACE 和衰老对大脑健康的不同影响
基本信息
- 批准号:10205925
- 负责人:
- 金额:$ 6.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-01 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAgeAge FactorsAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskBiologicalBloodBrainBrain DiseasesBrain-Derived Neurotrophic FactorChildChildhoodCognitionCognitiveCognitive deficitsCohort StudiesCollectionComputersDataDementiaDevelopmentEarly InterventionEducationElderlyEligibility DeterminationEnrollmentEventExposure toFemaleFundingFutureGoalsGoldHealthHigh PrevalenceHouseholdImpaired cognitionIndividualInjuryInterventionInvestigationKnowledgeLifeLife ExperienceLinkLongevityMeasurementMeasuresMemoryMemory LossMental DepressionMentorsMethodsModelingNational Institute of General Medical SciencesNeurocognitionNeurocognitiveNeurophysiology - biologic functionNeuropsychological TestsNeuropsychologyParticipantPathway interactionsPatternPerformancePersonsPilot ProjectsPopulationProcessProspective cohort studyPublic HealthQuestionnairesRecording of previous eventsResearchResearch PersonnelResourcesRiskRisk FactorsRoleSamplingScholarshipSerumStructureTestingTrainingTraumaUnited States National Institutes of HealthVenipuncturesVisitWomanWorkadverse childhood eventsagedbasebrain healthcognitive functioncognitive performancecognitive testingcohortcomorbiditydementia riskdeprivationdesignearly life adversityemerging adultexperiencehealthy aginghuman old age (65+)innovationmiddle ageneglectnervous system disorderneurocognitive testneurotrophic factornovelperformance testsrecruitrelating to nervous systemscreeningsuccess
项目摘要
PROJECT SUMMARY/ABSTRACT
Aging is the number one risk factor for cognitive decline and Alzheimer’s Disease and Related Dementias
(ADRD); however, decline in old age may reflect experiences over the entire lifespan. Prior research shows
how early-life experiences, such as education, have an influence on late-life cognitive performance and old-
age or ADRD cognitive trajectories. Additional early-life factors that may exacerbate neurocognitive
degeneration or ADRD risk include adverse childhood experiences (ACEs). An often unconsidered harm of
ACEs is the potential risk it poses to brain development and later-life cognitive impairment. ACEs are defined
as traumatic childhood events (e.g., abuse, deprivation or neglect, and household challenges). Findings linking
ACE exposure to future brain health and disease is concerning given the high prevalence of ACEs. Brain
derived neurotrophic factors (BDNF) are also linked to brain and cognitive health, with evidence that aging and
neurological diseases reduce the levels of BDNF. Low levels of BDNF in women have been linked to cognitive
impairments, depression, and Alzheimer’s disease; however, direct connections between cognitive function
and BDNF have yet to be examined. It is unknown how levels of BDNF are impacted by the process of aging
and traumatic experiences or how they relate to cognitive testing. Thus, in order to disentangle the contribution
of age and ACEs on brain health, it is essential to determine whether ACE-related patterns of cognitive deficits
are detectable on neuropsychological testing and whether they relate to BDNF levels among different age
cohorts with and without trauma history. Such data will help us understand the relationship between
performance-based vs. biologic indicators of brain function across ages. To begin to fill this knowledge gap, the
proposed study will leverage findings from an ongoing study of ACEs and neurotrophins in a middle-aged
sample to address the following aims: Aim 1: To characterize/define cognitive performance across the
emerging and older adult cohorts stratified by ACEs, and Aim 2: To characterize/define BDNF levels across the
two unexplored age cohorts stratified by ACEs. Using an observational cohort design, 100 adults―50
emerging adults and 50 older adults―will be recruited for the proposed study. Independent groups will be
matched by exposure to ACEs and other key covariates (e.g., education). Participant’s eligibility will be
assessed via an online screening questionnaire (and for older adults, an additional in-lab screening prior to
beginning the assessment) where eligibility criteria will be confirmed. Those who are eligible and willing to
participate will be invited to enroll in the study. Enrolled participants will then have blood drawn prior to
completing a computer based cognitive assessment (Automated Neuropsychological Assessment Metrics and
NIH-Toolbox Cognitive Battery). This study is an innovative investigation that will have important public health
implications. If funded, this study has the ability to identify novel risk factors (e.g., neurocognitive profiles
and/or brain substrates) as intervention targets to protect brain health and to promote healthy aging across the
lifespan.
项目总结/摘要
衰老是认知能力下降和阿尔茨海默病及相关痴呆症的头号危险因素
(ADRD);然而,老年的衰退可能反映了整个生命周期的经历。此前的研究显示,
如何早期生活的经验,如教育,对晚年的认知表现和老年人的影响,
年龄或ADRD认知轨迹。其他可能加剧神经认知的早期因素
退化或ADRD风险包括不良童年经历(ACE)。一种经常被忽视的伤害,
ACE是它对大脑发育和晚年认知障碍造成的潜在风险。ACE定义为
作为创伤性童年事件(例如,虐待、剥夺或忽视以及家庭挑战)。结果链接
由于ACE的高患病率,ACE暴露于未来的大脑健康和疾病是令人担忧的。大脑
衍生的神经营养因子(BDNF)也与大脑和认知健康有关,有证据表明,
神经系统疾病会降低BDNF的水平。女性BDNF水平低与认知功能有关
障碍,抑郁症和阿尔茨海默病;然而,认知功能之间的直接联系
和BDNF还有待检验目前还不清楚BDNF的水平如何受到衰老过程的影响。
和创伤经历,以及它们与认知测试的关系。因此,为了理清
年龄和ACE对大脑健康的影响,确定ACE相关的认知缺陷模式是至关重要的
是否与不同年龄的BDNF水平有关
有无创伤史的队列。这些数据将帮助我们了解
基于表现的指标与不同年龄段大脑功能的生物指标。为了开始填补这一知识空白,
一项拟议的研究将利用正在进行的一项中年人ACE和神经营养因子研究的结果,
目标1:表征/定义跨组织的认知表现,
新兴和老年人队列分层的ACE,和目标2:表征/定义BDNF水平在整个
两个未探索的年龄队列,按ACE分层。使用观察性队列设计,100名成人-50名
新成年人和50名老年人将被招募参加拟议的研究。独立团体将
与ACE暴露和其他关键协变量(例如,教育)。参与者的资格将是
通过在线筛查问卷进行评估(对于老年人,在
开始评估),其中将确认资格标准。那些有资格并愿意
将邀请参与者入组研究。入组的受试者将在
完成基于计算机的认知评估(自动神经心理评估),
NIH-NIHSS认知测验)。这项研究是一项创新的调查,将有重要的公共卫生
含义。如果获得资助,这项研究有能力识别新的风险因素(例如,神经认知侧貌
和/或脑基质)作为干预目标,以保护脑健康并促进整个
寿命
项目成果
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