METHODS - A randomised controlled trial of METhotrexate to treat Hand Osteoarthritis with Synovitis

方法 - 甲氨蝶呤治疗手部骨关节炎伴滑膜炎的随机对照试验

• 批准号: nhmrc : 1127981
• 负责人: Dr Andrew Teichtahl
• 金额: $ 52.58万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/methods-randomised-controlled-osteoarthritis-synovitis/948106
• 关键词: METHODS; randomised; controlled; trial; METhotrexate

Hand osteoarthritis (OA) is common, but has no treatment. Almost 50% of people with hand OA will have joint swelling (synovitis). The hand joint of people with synovitis are 3.5 times more likely to experience joint destruction within as little as 2 years. Drugs used to treat synovitis may reduce pain and joint destruction. We propose that treating patients with symptomatic hand OA and synovitis with the anti-synovitis drug, methotrexate, will be a major medical advance.

手部骨关节炎(OA)很常见，但没有治疗方法。近50%的手部骨性关节炎患者会出现关节肿胀(滑膜炎)。滑膜炎患者的手关节在短短两年内遭受关节破坏的可能性是普通人的3.5倍。用于治疗滑膜炎的药物可能会减轻疼痛和关节破坏。我们认为，使用抗滑膜炎药物甲氨蝶呤治疗有症状的手部骨关节炎和滑膜炎患者将是一个重大的医学进步。