Functional and Cognitive Rehabilitation of Hoarding Disorder

囤积症的功能和认知康复

• 批准号: 10378634
• 负责人: Catherine Ayers
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10378634
• 关键词: Activities of Daily Living; Address; Adult; Aftercare; Age; Caregiver Burden; Caring; Case Management; Chronic; Clinic; Cognitive; Communities; Compulsive Hoarding; Dangerousness; Data; Decision Making; Disease; Distress; Economic Factors; Elderly; Evaluation; Evidence based treatment; Executive Dysfunction; Fire - disasters; Food Contamination; Gender; Home; Home visitation; Housing; Impairment; Individual; Individual Differences; Interruption; Intervention; Knowledge; Left; Life; Measures; Mediating; Mediation; Medical; Mental Health; Modality; Nature; Older Population; Outcome; Participant; Pharmaceutical Preparations; Primary Health Care; Public Health; Quality of life; Randomized Controlled Trials; Recovery; Recovery of Function; Rehabilitation Outcome; Rehabilitation therapy; Research; Services; Severities; Site; Social Workers; Social isolation; Sorting - Cell Movement; Symptoms; Telemedicine; Telemental; Therapeutic Intervention; Training; Treatment Factor; Treatment outcome; Veterans; Visit; base; care delivery; clinical practice; cognitive rehabilitation; cognitive testing; disability; executive function; experience; fall risk; follow-up; functional disability; functional improvement; functional outcomes; human old age (65+); implementation barriers; improved; innovation; novel strategies; nutrient deprivation; precision medicine; preference; primary outcome; programs; psychiatric comorbidity; reduce symptoms; rehabilitative care; secondary outcome; standard of care; therapy design; trial comparing

Hoarding Disorder (HD) is a chronic, progressive, and debilitating psychiatric condition that leads to devastating personal and public health consequences. HD is defined by persistent difficulty discarding or parting with possessions due to distress associated with discarding, urges to save, and/or difficulty making decisions about what to keep and what to discard. Subsequent accumulation of clutter can become so dangerous that it puts individuals at risk of falls, fires, infestations, food contamination, medication mismanagement, social isolation, nutritional deprivation, and eviction. Medical problems, activities of daily living (ADL) impairment, decreased quality of life, and functional disability are associated with HD symptom severity. HD starts early in life, does not remit if left untreated, and increases in severity with age. The highest rates of HD are seen in older adults, with up to 25% experiencing HD symptoms. The population of older Veterans is substantial, with 41% expected to be over the age of 65 by 2030. Recent research has found that Veterans with HD experience more medical and psychiatric comorbidities; thus, Veterans represent a group with high needs for effective HD treatment to reduce disability and improve multiple aspects of functioning. Dr. Ayers’ group has developed and evaluated Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) in randomized controlled trials. The CREST intervention provides compensatory cognitive strategies to address the executive dysfunction typical of individuals with HD, and then uses exposure therapy to reduce the distress associated with discarding items. CREST improves HD symptoms and functioning in Veterans with HD, but the intensive nature of the program (6-8 months) burdens mental health clinics and slows progress. Given that the home is the primary site of clutter and the need for sorting of a large volume of items during treatment, a home-based treament approach is needed. To reduce the burdens and barriers to implementation of CREST, we will use a novel approach, referred to as Personalized-CREST, designed to reflect a precision medicine approach to evidence-based treatment for HD. Personalized-CREST will be more individualized (matching cognitive strategies to Veteran needs and priorities), more efficient (shorter timeframe over 12 weeks), and easier to access (in-home sessions and home-based video telemedicine [HBVT] sessions). Recent pilot data suggest that HBVT for HD is feasible, efficacious, requires minimal adaptation, and is a preferred. Based on 73 non-Veteran community Personalized-CREST completers, results indicated statistically significant decreases in functional impairment, disability, and of HD symptom severity. The proposed randomized controlled trial will compare Personalized-CREST to a case management (CM) control condition for 130 adult Veterans with HD. Personalized-CREST will be delivered twice a week in the home (one face-to-face and one HBVT session) for 60 minutes per session. A total of 24 sessions will be provided over 3 months. Per the standard of care for CM, a social worker will visit the Veteran once a week in their home. A thorough evaluation of treatment outcomes, including multifaceted functional and rehabilitative outcomes, including quality of life and hoarding severity will be conducted at baseline (0 months), mid- treatment, end of treatment (3 months), and 6-month follow-up. We will also examine factors that mediate improvement in Personalized-CREST (improved executive functioning and reduction in avoidance of discarding items). Individual factors (e.g., age, baseline executive functioning, baseline HD severity, gender and economic factors) and treatment factors (e.g., attendance) will be explored as moderators. The proposed study will generate knowledge to advance the rehabilitative care of Veterans with HD.

囤积障碍（HD）是一种慢性的、进行性的、使人衰弱的精神疾病，它会导致