Neural mechanisms of sensory reactivity and regulation in autism across development

自闭症跨发育过程中感觉反应和调节的神经机制

• 批准号: 10378475
• 负责人: Shulamite Abra Green
• 金额: $ 68.79万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10378475
• 关键词: Adolescence; Adult; Age; Amygdaloid structure; Arousal; Attention; Attenuated; Behavioral; Biological; Brain; Brain region; Child; Childhood; Clinical; Communities; Coping Skills; Cues; Data; Development; Developmental Course; Developmental Delay Disorders; Diagnostic; Emotional; Emotions; Foundations; Functional Magnetic Resonance Imaging; Goals; Impairment; Individual; Individual Differences; Intervention; Knowledge; Life; Loudness; Methods; Neurodevelopmental Disorder; Noise; Positioning Attribute; Prefrontal Cortex; Regulation; Sampling; Schools; Sensory; Severities; Spectrum Analysis; Stimulus; Testing; Thalamic structure; Touch sensation; Translating; Translations; Work; Youth; adolescent with autism spectrum disorder; autism spectrum disorder; autistic children; base; behavior measurement; design; developmental disease; emotion regulation; follow-up; gamma-Aminobutyric Acid; habituation; imaging study; improved; individuals with autism spectrum disorder; knowledge of results; longitudinal analysis; longitudinal design; neurobiological mechanism; neuromechanism; neuroregulation; personalized intervention; psychopharmacologic; relating to nervous system; resilience; response; sensory cortex; sensory gating; sensory mechanism; sensory stimulus; social; therapy design

PROJECT SUMMARY/ABSTRACT Sensory over-responsivity (SOR) is an impairing condition manifested as extreme sensitivity to stimuli such as loud noises or being touched. SOR is present across neurodevelopmental disorders, but is particularly prevalent in youth with autism spectrum disorders (ASD) with rates of at least 56-70%. SOR is a fundamental limitation to individuals’ ability to participate in the community, succeed in school, complete daily living tasks, and interact socially. Despite this, there are almost no empirically-based treatments for SOR, in part due to the lack of understanding of its underlying biological mechanisms. Furthermore, while SOR tends to decline across adolescence into adulthood, there is little understanding as to why and for whom it improves. Thus, the primary goals of this study are to identify the developmental course of SOR as well as neurobiological mechanisms through which it can be attenuated, both essential to developing interventions. Our team has conducted some of the first studies identifying key neural mechanisms of SOR across youth with ASD, including 1) over-reactive brain responses/reduced habituation in primary sensory cortices and amygdala, 2) reduced thalamic GABA, and 3) reduced prefrontal cortex (PFC)-amygdala functional connectivity during aversive sensory stimulation. Our prior studies also indicate that the subset of youth with ASD but low SOR show heightened amygdala-prefrontal connectivity during sensory stimulation, suggesting a mechanism for resilience against SOR. Our preliminary data also suggest that amygdala reactivity to aversive sensory stimulation declines with age while PFC activation increases. This proposal seeks to build on this foundation by examining biological mechanisms through which SOR may be attenuated either through natural development or through direct intervention, with the goal of proximate translation to treatment. Using a combined cross-sectional and longitudinal design, we will examine: 1) developmental changes in sensory reactivity in ASD compared to typically developing (TD) children; 2) developmental changes in two candidate neural mechanisms of sensory regulation (thalamic GABA and PFC- amygdala connectivity), and 3) the relative ability of two different emotion regulation strategies (attention cuing vs. reappraisal) in engaging sensory regulation. Based on our prior studies and preliminary data, we expect to see that behavioral and neural markers of SOR decrease with age, but that this decline happens later than is typical for youth with ASD, indicating a developmental delay in sensory regulation. We further expect that of our two candidate top-down mechanisms of sensory regulation that prefrontal-amygdala connectivity but not thalamic GABA will improve with development, which will inform our understanding of why SOR decreases with age and how best to treat it at different stages of development. Finally, we will compare the relative ability of attention cuing vs. reappraisal to engage PFC for youth of different ages and SOR severity. Results will directly inform both behavioral and psychopharmacological personalized interventions for SOR.

项目总结/文摘