Modular synthesis of bioactive polycyclic polyprenylated acyl phloroglucinols by a symmetry-guided approach

通过对称引导方法模块化合成生物活性多环聚异戊二烯化酰基间苯三酚

• 批准号: 10387314
• 负责人: Trevor William Butcher
• 金额: $ 6.68万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-03 至 2025-02-02
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10387314
• 关键词: 3-hydroxybutanal; Adamantane; Affect; Alkylation; Anti-Inflammatory Agents; Antidepressive Agents; Antioxidants; Attention; Clinical; Communities; Complex; DNA-Directed DNA Polymerase; Development; Doxorubicin; Exhibits; FDA approved; Goals; Health; Human; Hypericum perforatum; Lead; Left; Medicine; Metals; Methods; Natural Products; Organic Synthesis; Outcome; Pharmaceutical Preparations; Pharmacology; Phloroglucinol; Phosgene; Play; Positioning Attribute; Reaction; Reporting; Research; Role; Route; Scheme; Structure; Structure-Activity Relationship; Topoisomerase-I Inhibitor; Type I DNA Topoisomerases; analog; anti-cancer; anticancer activity; antimicrobial; appendage; base; bioactive natural products; drug development; drug discovery; enolate; hyperforin; nonane; novel; prenyl; scaffold; stereochemistry

PROJECT SUMMARY Natural products continue to play an important role in pharmacology by serving as potent medicines and new lead compounds for drug discovery. A particularly important class of bioactive natural products are the polycyclic polyprenylated acylphloroglucinols (PPAPs), which are known for their diverse bioactivities including anticancer, antiviral, anti-inflammatory, antidepressant, antimicrobial, antioxidant, and neuroprotective activities. The most well-known PPAP, hyperforin, is the active constituent of St. John’s wort, an herbal antidepressant approved for clinical use in the UK and available over-the-counter worldwide. PPAPs are characterized by a highly oxygenated, polycyclic core decorated by prenyl-derived substituents. Because the range of bioactivities offered by these compounds is controlled by the precise identity, position, and configuration of these substituents, modular syntheses of PPAPs that enable the rapid synthesis of numerous natural and unnatural PPAPs have been highly sought after. Although PPAPs have attracted significant attention from the synthetic community, nearly all efforts have been devoted to the synthesis of PPAPs containing a bicyclo[3.3.1]nonane-2,4,9-trione core. This proposal discloses the first modular route to tricyclic PPAPs and the first route to PPAPs containing a bicyclo[3.3.1]nonane-2,8-dione core. The tricyclic PPAPs are more complex than bicyclic PPAPs and consequently have not been prepared in a modular fashion. Several natural products with impressive bioactivities lie within the class of molecules we will target, including garcixanthochymones A and B, which exhibit antiproliferative activities comparable to the FDA-approved chemotherapeutic doxorubicin, and plukenetione A, which exhibits antitumor activity by inhibiting DNA polymerase and topoisomerase I. To achieve these syntheses, we have outlined a plan that defers the installation of each of the substituents to the end of the synthesis, thereby harnessing the hidden symmetry of adamantane-type PPAPs and bicyclo[3.3.1]nonane-2,8-dione-type PPAPs. In the context of this synthesis, we will develop new desymmetrizations that set quaternary stereocenters, directed asymmetric conjugate additions, and bridgehead metalations. These methods will have broad applications in organic synthesis beyond the field of natural product synthesis. The proposed research will positively affect human health by expanding the availability of complex, bioactive PPAPs, ultimately accelerating the discovery of new treatments based on these privileged scaffolds.

项目总结 天然产物作为强效药物和新药，在药理学中继续发挥着重要作用。 用于药物发现的先导化合物。一类特别重要的生物活性天然产物是多环化合物 聚戊烯基间苯三酚(PPAP)，以其多种生物活性而闻名，包括抗癌， 抗病毒、抗炎、抗抑郁、抗菌、抗氧化和神经保护活性。最多的 众所周知的PPAP，金丝桃素，是圣约翰麦芽汁的有效成分，一种草本抗抑郁剂，被批准用于 在英国临床使用，并在全球范围内提供非处方药。 PPAP的特点是具有高度含氧性的多环核心，由戊烯基衍生物取代基装饰。 因为这些化合物提供的生物活性范围是由精确的身份、位置和 这些取代基的构型，PPAP的模块化合成，使许多 天然和非天然的PPAP一直备受追捧。尽管PPAP引起了人们的极大关注 从合成界来看，几乎所有的努力都致力于合成含有 双环[3.3.1]壬烷-2，4，9-三酮核。该方案公开了到三环PPAP的第一条模块化路线和 含双环[3.3.1]壬烷-2，8-二酮核的PPAP的第一条路线。三环PPAP比较复杂 而不是双环PPAP，因此没有以模块化的方式制备。几种天然产品 令人印象深刻的生物活性存在于我们将针对的分子类别中，包括garcixanthchymones A 和B，它们表现出与FDA批准的化疗药物阿霉素相当的抗增殖活性， 和Plukenetione A，它通过抑制DNA聚合酶和拓扑异构酶I而显示出抗肿瘤活性。 为了实现这些合成，我们概述了一个推迟每个取代基安装的计划 从而利用金刚烷型PPAP的隐藏对称性 双环[3.3.1]壬烷-2，8-二酮型PPAP。在这一综合的背景下，我们将开发新的 设置四元立体中心、定向不对称共轭加成和桥头的去对称化 金属化。这些方法在天然产物以外的有机合成领域具有广阔的应用前景。 综合。这项拟议的研究将通过扩大复杂的、 生物活性PPAP，最终加速了基于这些特权支架的新疗法的发现。