2022 Oxygen Radicals GRC/GRS

项目摘要 本申请寻求对2022年戈登氧自由基研究会议(GRC)的支持： 氧自由基化学与医学的联系，于2022年1月30日至2月4日举行，以及 在此之前，由受训者为受训者组织的戈登研究研讨会(GRS)于2022年1月29日至30日举行。 GRC和GRS都将在加利福尼亚州文图拉的文图拉海滩万豪酒店举行。我们设计了一个激动人心的 计划，汇聚顶尖科学家和培训科学家，代表不同领域的研究 氧自由基，从基础化学到临床应用和试验。该计划的重点是在 氧自由基的化学、分析、生物化学和生物学，涵盖癌症、衰老和 与年龄相关的疾病、肺部疾病、神经疾病和心脏代谢疾病。该计划 包括两个主题演讲，题为Keap1-NRF2监管系统及其在健康和疾病中的作用 和p62-NRF2轴在肥胖诱导的肝癌发展中的作用，以及31个额外邀请 由资深科学家和氧自由基领域的后起之秀主持的讲座。我们已经预订了12个房间。 口头陈述的时段，选自提交的摘要。组织者将确保妇女和 代表不足的少数族裔科学家将积极参加GRC，或通过邀请的选拔 演讲者或讨论领导者，通过从提交的摘要中选择演讲者时段，或作为演讲者 海报预览会期间的海报和演示者。海报预览环节将特别 重要的是给海报主持人一个简短的时间向观众介绍他们海报的主要内容， 为所有与会者做好准备，以便在海报会议期间进一步进行充满活力的交流和讨论。在被邀请的人中 演讲者和讨论负责人，46%是女性，所有GRC的与会者都将有机会 解决女性在科学领域面临的挑战，以及在《权力一小时》和 妇女代表会议。GRC将创造包容和归属感的环境，具体地说 将少数群体和科学家纳入社区培训，例如通过欢迎桌。我们会 确保在讨论环节中，学员将优先提出第一个问题。特邀演讲者 将在以下会议上分享尖端科学和新发现：主旨会议：一体化细胞 应激反应：基因调控的氧化还原控制；氧化还原应激的化学和分析；氧化还原生化 蛋白质；癌症中的氧化还原信号：从机制到治疗；衰老和年龄相关的氧化还原途径 疾病；神经疾病中的氧化还原机制；研究氧化还原信号的新方法；氧化应激 在感染、免疫和肺部疾病中；心脏代谢疾病中的氧化还原信号。

Project Summary This application seeks support for the 2022 Gordon Research Conference (GRC) on Oxygen Radicals: Connecting the Chemistry of Oxygen Radicals to Medicine, taking place from January 30-February 4, 2022, and preceded by the Gordon Research Seminar (GRS), organized by trainees for trainees, on January 29-30, 2022. Both GRC and GRS will be held at the Ventura Beach Marriott in Ventura, California. We designed an exciting program, bringing together leading scientists and scientists in training, representing diverse fields of research on oxygen radicals, from basic chemistry to clinical applications and trials. The program focuses on advances in the chemistry, analysis, biochemistry, and biology of oxygen radicals, covering redox signaling in cancer, aging and age-related diseases, pulmonary diseases, neurological disorders, and cardiometabolic diseases. The program includes two keynote lectures entitled The KEAP1-NRF2 regulatory system and its role in health and disease and P62-NRF2 axis in the development of obesity-induced liver cancer, together with 31 additional invited lectures, presented by senior scientists and rising stars in the area of oxygen radicals. We have reserved 12 slots for oral presentations, selected from submitted abstracts. The organizers will ensure that women and underrepresented minority scientists will actively participate in the GRC, either through selection as invited speakers or discussion leaders, through selection for speaker slots from submitted abstracts, or as presenters of posters and presenters during the poster preview sessions. The poster preview sessions will be especially important to give poster presenters a brief time to introduce the main content of their posters to the audience, preparing all attendees for further vibrant exchange and discussions during the poster sessions. Among invited speakers and discussion leaders, 46% are female, and all attendees of the GRC will have the opportunity to address challenges women face in science and issues of diversity and inclusion during the Power Hour and Representation by Women session. The GRC will create an environment of inclusion and belonging, specifically integrating minorities and scientist in training into the community, for example through welcome tables. We will ensure that during discussion sections, trainees will be given priority to ask the first questions. Invited speakers will share cutting edge science and new discoveries the following sessions: Keynote session: Integrative cellular stress responses: redox control of gene regulation; Chemistry and analysis of redox stress; Redox biochemistry of proteins; Redox signaling in cancer: from mechanisms to therapy; Redox pathways in aging and age-related diseases; Redox mechanisms in neurological diseases; Novel methods to study redox signaling; Oxidative stress in infection, immunity and pulmonary diseases; Redox signaling in cardiometabolic diseases.