Antibody Profiles and Genetics of Pernio-Like Lesions during the COVID-19 pandemic

COVID-19 大流行期间冻疮样病变的抗体谱和遗传学

• 批准号: 10212890
• 负责人: Esther E Freeman
• 金额: $ 5.39万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-07 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10212890
• 关键词: 2019-nCoV; Acute; Africa South of the Sahara; Antibodies; Antibody Response; Area; Biological; COVID-19; COVID-19 patient; Caring; Cellular Immunity; Cessation of life; Chilblains; Clinical; Clinical Trials; Collaborations; Communities; Complex; Convalescence; Cutaneous; Databases; Dermatologic; Dermatology; Development; Disease; Enrollment; Family; Future; General Hospitals; Genetic; Genetic Determinism; Genetic Polymorphism; HIV; Hand; Hospitalization; Immune response; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Information Systems; Infrastructure; Institution; International; Intramural Research; Investigation; Kaposi Sarcoma; Knowledge; Laboratories; Lesion; Massachusetts; Molecular; Patients; Phenotype; Proteomics; Protocols documentation; Reporting; Research; Resources; Role; SARS-CoV-2 infection; Sampling; Serology; Skin; Specimen; Symptoms; Testing; Therapeutic; Time; Toes; United States National Institutes of Health; Vaccines; Viral; Virus; Virus Diseases; acute infection; adaptive immune response; antibody detection; asymptomatic COVID-19; clinical phenotype; cohort; coronavirus disease; foot; improved; pandemic disease; patient population; patient response; patient subsets; recruit; response; sample collection; skin disorder; skin lesion

A subset of patients with coronavirus disease-2019 (COVID-19) develop cutaneous manifestations of their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, including pernio of their feet and hands, known as “COVID toes.” These patients tend to have a mild disease course, which may indicate successful viral control by the host. By leveraging an existing patient cohort at Massachusetts General Hospital (MGH), and the extensive laboratory infrastructure at the NIH, this proposal aims to elucidate the complex determinants of a unique phenotype of COVID-19: pernio/ “COVID toes,” with the following Aims. Aim 1: To evaluate genetic determinants of pernio-like lesions (“COVID toes”) in response to SARS-CoV-2 infection. Aim 2: To characterize the inflammatory and serological response during acute infection and convalescence of patients with SARS-CoV-2 who develop pernio-like lesions as a symptom of COVID-19. Biological samples will be obtained at MGH and sent to collaborating labs at the NIH. In particular, this proposal will help us understand the host immune response to COVID-19 by focusing on patients who have controlled the disease and have had relatively mild clinical courses, as characterized by their skin lesions. Successful completion of our aims will immediately and directly respond to important gaps in our knowledge regarding mild/asymptomatic COVID-19, which in turn can help inform our understanding of how to harness this type of successful control for other patients.

2019冠状病毒病（COVID-19）患者的一个子集出现严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）感染的皮肤表现，包括脚和手的冻疮，称为“COVID脚趾”。这些患者往往有一个温和的疾病过程，这可能表明成功的病毒控制的主机。通过利用马萨诸塞州总医院（MGH）现有的患者队列和NIH广泛的实验室基础设施，该提案旨在阐明COVID-19独特表型的复杂决定因素：pernio/“COVID脚趾”，其目的如下。目的1：评估SARS-CoV-2感染后出现的冻疮样病变（“COVID脚趾”）的遗传决定因素。目标二：描述SARS-CoV-2患者急性感染和恢复期间的炎症和血清学反应，这些患者出现作为COVID-19症状的冻疮样病变。生物样本将在MGH获得，并送往NIH的合作实验室。特别是，该提案将帮助我们了解宿主对COVID-19的免疫反应，重点关注已控制疾病并具有相对温和临床病程的患者，其特征是皮肤病变。成功完成我们的目标将立即直接回应我们对轻度/无症状COVID-19的知识的重要空白，这反过来又有助于我们了解如何为其他患者利用这种成功的控制。