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Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis

Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis
针对帕塔纳托细胞焦亡调节坏死途径的辐射缓解剂
批准号：
10212243
负责人：
Hülya Bayir
金额：
$46.79万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
未结题
起止时间：
2020-07-08 至 2025-06-30
来源：
https://reporter.nih.gov/project-details/10212243
关键词：
AcuteAntibodiesAntigensApoptosisApoptoticBacteriaBloodCASP1 geneCell DeathCell Membrane PermeabilityCell NucleusCell membraneCellsCessation of lifeChemotactic FactorsComputer ModelsDataDevelopmentDiseaseDoseEffectivenessEpithelial CellsEventExposure toFree RadicalsFundingGenerationsGoalsHematopoieticIL18 geneIn VitroInfectionInflammasomeInflammatoryInflammatory ResponseInterleukin-1 ReceptorsInterleukin-1 betaInterleukin-18IntestinesIonizing radiationKnowledgeLinkLipidsMediatingMedicalMitochondriaMitochondrial ProteinsMolecularNecrosisNuclear RadiologyNuclear TranslocationNuclear WarfareOuter Mitochondrial MembraneOxidation-ReductionOxidesParticipantPathogenesisPathogenicityPathway interactionsPhospholipidsPoly(ADP-ribose) PolymerasesProductionProliferatingProteinsRadiationRadiation AccidentsRadiation InjuriesRadiation exposureRadioactiveReactive Oxygen SpeciesRecoveryRoleSignal PathwaySignal TransductionStreamStressStructure-Activity RelationshipSyndromeTestingTherapeuticTissuesWaterWhole-Body Irradiationanakinraapoptosis inducing factorbaseclinically translatablecytokinedesigneffectiveness evaluationgastrointestinal epitheliumimprovedin vivo Modelinhibitor/antagonistinterestirradiationlipid biosynthesislipid mediatorlipidomicsnovelnovel therapeuticsoxidationpathogenprogramsradiation mitigationradiation mitigatorradiological attackresponsesmall molecule inhibitortrafficking

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会议论文
Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis
Oxidative Lipidomics in Pediatric Traumatic Brain Injury
Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis
Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis
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