05 Tissue Biospecimen and Pathology Resource

05 组织生物样本和病理学资源

• 批准号: 10212253
• 负责人: IGNACIO I. WISTUBA
• 金额: $ 94.71万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-28 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10212253
• 关键词: Accreditation; Animal Model; Animals; Biological; Biological Markers; Blood; Blood Cells; Blood specimen; Cancer Center; Cancer Center Support Grant; Capital; Cataloging; Cell Separation; Cells; Cerebrospinal Fluid; Clinical Laboratory Improvement Amendments; Clinical Trials; Collection; Consent; Consultations; Core Facility; Cytology Histology; Ensure; Equipment; Funding; Genomics; Goals; Grant; Guidelines; Head; Health; Histology; Human; Immune; Immunohistochemistry; Immunology procedure; In Situ; In Situ Hybridization; Institution; Institutional Review Boards; International; Journals; Laboratories; Liquid substance; Medicine; Molecular; Paper; Pathologist; Pathology; Patients; Peer Review; Plasma; Procedures; Process; Protocols documentation; Publications; Quality Control; Research; Research Personnel; Resource Sharing; Resources; Secure; Services; Slide; Societies; Specimen; Stains; Standardization; System; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; animal tissue; base; biobank; cell free DNA; data management; digital pathology; exosome; flexibility; human subject; human subject protection; human tissue; immunotherapy clinical trials; improved; innovation; laboratory facility; laser capture microdissection; liquid biopsy; member; molecular pathology; pre-clinical; process optimization; professor; programs; quality assurance; recruit; repository; research study; tissue resource

PROJECT SUMMARY: TISSUE BIOSPECIMEN AND PATHOLOGY RESOURCE (TBPR) The Tissue Biospecimen and Pathology Resource (TBPR) provides a flexible, sophisticated and well-functioning institutional biorepository for human tissue specimens in conjunction with an advanced research histology core facility that supports histopathologic characterization of human and animal tissue specimens. The biorepository Institutional Tissue Bank (ITB) and the Research Histology Facility (RHF) are 2 longstanding, mature, highly functional CCSG-supported shared resources that comprise the TBPR. The ITB is a CLIA-accredited facility that provides center members with access to human tissues, blood, and other fluids obtained from consenting patients under Institutional Review Board-approved protocols. The RHF provides routine and advanced cell- and tissue-based services to investigators. The TBPR supports the entire spectrum of research studies, including biomarker studies in clinical trials as well as basic and pre-clinical animal model research. During the last funding cycle, the ITB recruited board-certified pathologists' assistants to standardize and improve the quality of tissue collection throughout the institution. This effort continues to support new institutional initiatives and strategic alliances on clinical trials for the longitudinal collection of tissue and blood specimens for downstream molecular and immune profiling analyses and the associated implementation of new workflow processes. The TBPR director is Dr. Ignacio Wistuba, chair of Translational Molecular Pathology, and the co-directors are Dr. Stanley Hamilton, head of the Division of Pathology and Laboratory Medicine, and Dr. Dipen Maru, a professor in Translational Molecular Pathology. The TBPR provides key services, including: biospecimen collection, processing, distribution, and quality control; unique, specialized services, such as histochemical stains, immunohistochemistry (IHC), tissue microarray, laser-capture microdissection, in situ hybridization, and digital pathology that utilizes newly acquired, state-of-the-art equipment such as tissue microarrayers, IHC autostainers, and Aperio slide scanners; and new pathology consultation services. Over the last grant cycle, the ITB collected 637,042 specimens, and the RHF performed 1,069,932 procedures. MD Anderson has supported the TBPR with capital equipment funds that total $1,783,014 (ITB $385,387; RHF $1,397,627). Since the previous grant cycle, the ITB and RHL have supported 234 and 499 cancer center members, respectively, and usage was evenly distributed among all 16 CCSG programs. Peer review-funded research accounts for over 80% of total usage, and 32% ($614,243) is requested from the CCSG in grant Yr44. The TBPR facilitated the publication of 481 peer-reviewed papers, including 358 (74%) in journals with IF >5, 159 (33%) in journals with IF >10, and 70 (15%) in journals with IF >20. During the next funding cycle, the TBPR will continue to standardize, streamline, and optimize processes, thereby allowing the facilities to provide high-quality expedited services.

项目摘要：组织生物样本和病理学资源 (TBPR) 组织生物样本和病理学资源 (TBPR) 提供了灵活、复杂且功能良好的资源 人体组织标本机构生物样本库与先进的研究组织学核心相结合 支持人类和动物组织标本的组织病理学表征的设施。生物样本库 机构组织库 (ITB) 和组织学研究设施 (RHF) 是两个历史悠久、成熟、高度 组成 TBPR 的 CCSG 支持的功能性共享资源。 ITB 是经 CLIA 认证的机构， 为中心成员提供获得同意后获得的人体组织、血液和其他液体的机会 接受机构审查委员会批准的方案的患者。 RHF 提供常规和先进的细胞和 为研究人员提供基于组织的服务。 TBPR 支持整个范围的研究，包括 临床试验中的生物标志物研究以及基础和临床前动物模型研究。上次融资期间 周期中，ITB 招募了经过委员会认证的病理学家助理来标准化和提高组织质量 整个机构的收集。这项努力将继续支持新的机构举措和战略 纵向收集组织和血液样本用于下游分子研究的临床试验联盟 免疫分析和新工作流程的相关实施。 TBPR 主任是转化分子病理学主席 Ignacio Wistuba 博士，联合主任是 Stanley 博士 汉密尔顿（Hamilton），病理学和实验医学部主任，以及迪彭·马鲁（Dipen Maru）博士，教授 转化分子病理学。 TBPR 提供关键服务，包括：生物样本采集、 加工、分销和质量控制；独特的专业服务，例如组织化学染色， 免疫组织化学 (IHC)、组织微阵列、激光捕获显微切割、原位杂交和数字化 病理学利用新购置的最先进的设备，如组织微点阵仪、IHC 自动染色仪、 和 Aperio 玻片扫描仪；和新的病理咨询服务。在上一个拨款周期中，ITB 收集了 637,042 个样本，RHF 执行了 1,069,932 次手术。 MD 安德森大学 (MD Anderson) 支持 TBPR 资本设备基金总计 1,783,014 美元（ITB 385,387 美元；RHF 1,397,627 美元）。自上一个资助周期以来， ITB 和 RHL 分别支持了 234 名和 499 名癌症中心成员，使用情况均匀 分布在所有 16 个 CCSG 计划中。同行评审资助的研究占总使用量的 80% 以上， 向 CCSG 申请第 44 年拨款的 32%（614,243 美元）。第 481 章 同行评审论文，其中 IF >5 的期刊有 358 篇（74%），IF >10 的期刊有 159 篇（33%），70 篇 (15%) 在 IF >20 的期刊中。在下一个资助周期中，TBPR 将继续标准化、精简、 并优化流程，从而使设施能够提供高质量的加急服务。