05 Tissue Biospecimen and Pathology Resource

05 组织生物样本和病理学资源

• 批准号: 9794660
• 负责人: IGNACIO I. WISTUBA
• 金额: $ 94.71万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9794660
• 关键词: Accreditation; Amendment; Animal Model; Animals; Biological; Biological Markers; Blood; Blood Cells; Blood specimen; Cancer Center; Cancer Center Support Grant; Capital; Cataloging; Catalogs; Cell Separation; Cells; Cerebrospinal Fluid; Clinical; Clinical Trials; Collection; Consent; Consultations; Core Facility; Cytology Histology; Ensure; Equipment; Funding; Genomics; Goals; Grant; Guidelines; Head; Health; Histology; Human; Immune; Immunohistochemistry; Immunology procedure; In Situ; In Situ Hybridization; Institution; Institutional Review Boards; International; Journals; Laboratories; Liquid substance; Medicine; Molecular; Paper; Pathologist; Pathology; Patients; Peer Review; Plasma; Procedures; Process; Protocols documentation; Publications; Quality Control; Research; Research Personnel; Resource Sharing; Resources; Secure; Services; Slide; Societies; Specimen; Stains; Standardization; System; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; animal tissue; base; biobank; cell free DNA; data management; digital pathology; exosome; flexibility; human subject; human subject protection; human tissue; immunotherapy clinical trials; improved; innovation; laboratory facility; laser capture microdissection; liquid biopsy; member; molecular pathology; pre-clinical; process optimization; professor; programs; quality assurance; recruit; repository; research study; tissue resource

PROJECT SUMMARY: TISSUE BIOSPECIMEN AND PATHOLOGY RESOURCE (TBPR) The Tissue Biospecimen and Pathology Resource (TBPR) provides a flexible, sophisticated and well-functioning institutional biorepository for human tissue specimens in conjunction with an advanced research histology core facility that supports histopathologic characterization of human and animal tissue specimens. The biorepository Institutional Tissue Bank (ITB) and the Research Histology Facility (RHF) are 2 longstanding, mature, highly functional CCSG-supported shared resources that comprise the TBPR. The ITB is a CLIA-accredited facility that provides center members with access to human tissues, blood, and other fluids obtained from consenting patients under Institutional Review Board-approved protocols. The RHF provides routine and advanced cell- and tissue-based services to investigators. The TBPR supports the entire spectrum of research studies, including biomarker studies in clinical trials as well as basic and pre-clinical animal model research. During the last funding cycle, the ITB recruited board-certified pathologists' assistants to standardize and improve the quality of tissue collection throughout the institution. This effort continues to support new institutional initiatives and strategic alliances on clinical trials for the longitudinal collection of tissue and blood specimens for downstream molecular and immune profiling analyses and the associated implementation of new workflow processes. The TBPR director is Dr. Ignacio Wistuba, chair of Translational Molecular Pathology, and the co-directors are Dr. Stanley Hamilton, head of the Division of Pathology and Laboratory Medicine, and Dr. Dipen Maru, a professor in Translational Molecular Pathology. The TBPR provides key services, including: biospecimen collection, processing, distribution, and quality control; unique, specialized services, such as histochemical stains, immunohistochemistry (IHC), tissue microarray, laser-capture microdissection, in situ hybridization, and digital pathology that utilizes newly acquired, state-of-the-art equipment such as tissue microarrayers, IHC autostainers, and Aperio slide scanners; and new pathology consultation services. Over the last grant cycle, the ITB collected 637,042 specimens, and the RHF performed 1,069,932 procedures. MD Anderson has supported the TBPR with capital equipment funds that total $1,783,014 (ITB $385,387; RHF $1,397,627). Since the previous grant cycle, the ITB and RHL have supported 234 and 499 cancer center members, respectively, and usage was evenly distributed among all 16 CCSG programs. Peer review-funded research accounts for over 80% of total usage, and 32% ($614,243) is requested from the CCSG in grant Yr44. The TBPR facilitated the publication of 481 peer-reviewed papers, including 358 (74%) in journals with IF >5, 159 (33%) in journals with IF >10, and 70 (15%) in journals with IF >20. During the next funding cycle, the TBPR will continue to standardize, streamline, and optimize processes, thereby allowing the facilities to provide high-quality expedited services.

项目总结：组织生物标本和病理学资源（TBPR） 组织生物标本和病理学资源（TBPR）提供了一个灵活，复杂和功能良好的 与先进的研究组织学核心相结合的人体组织标本的机构生物储存库 支持人类和动物组织标本组织病理学表征的机构。生物储存库 机构组织库（ITB）和研究组织学设施（RHF）是两个历史悠久，成熟，高度 功能性CCSG支持的共享资源，包括TBPR。ITB是CLIA认证的设施， 为中心成员提供获取人体组织、血液和其他液体的途径， 根据机构审查委员会批准的方案治疗患者。RHF提供常规和先进的细胞-和 为研究者提供组织服务。TBPR支持整个研究范围，包括 在临床试验以及基础和临床前动物模型研究中进行生物标志物研究。在最后一次融资中 ITB招募了委员会认证的病理学家助理，以标准化和提高组织质量 整个机构的收藏。这一努力继续支持新的机构倡议和战略 纵向收集组织和血液样本进行下游分子检测的临床试验联盟 和免疫分析以及新工作流程的相关实施。TBPR 主任是伊格纳西奥维斯图巴博士，转化分子病理学的主席，联合主任是斯坦利博士 病理学和实验室医学系主任汉密尔顿和纽约大学教授Dipen Maru博士 转化分子病理学。TBPR提供的主要服务包括：生物标本采集， 加工、配送和质量控制;独特的专业服务，如组织化学染色， 免疫组织化学（IHC）、组织微阵列、激光捕获显微切割、原位杂交和数字化 病理学，利用新获得的，国家的最先进的设备，如组织微阵列，免疫组化染色， 和Aperio载玻片扫描仪;以及新的病理咨询服务。在上一个赠款周期，ITB收集了 637，042例标本，RHF进行了1，069，932例手术。MD安德森支持TBPR， 资本设备资金共计1，783，014美元（ITB 385，387美元; RHF 1，397，627美元）。自上一个赠款周期以来， ITB和RHL分别为234名和499名癌症中心成员提供了支持，使用情况均匀 分布在所有16个CCSG项目中。同行评议资助的研究占总使用量的80%以上， 和32%（$614，243）是要求CCSG在补助金Yr 44。TBPR促进了481 同行评审论文，包括358篇（74%）发表在IF >5的期刊上，159篇（33%）发表在IF >10的期刊上， (15%）。在下一个供资周期，TBPR将继续标准化，精简， 并优化流程，从而使设施能够提供高质量的加急服务。