Role of Structural Remodeling in Atrial Fibrillation

结构重塑在心房颤动中的作用

• 批准号: 10389280
• 负责人: Eugene Kwan
• 金额: $ 3.59万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10389280
• 关键词: Ablation; Affect; Animals; Anisotropy; Architecture; Area; Arrhythmia; Atrial Fibrillation; Characteristics; Clinical Trials; Coupled; Data; Development; Electrophysiology (science); Fiber; Fibrosis; Gap Junctions; Goals; Goat; Heart Atrium; Heterogeneity; Histology; Impairment; Implant; Lead; Link; Magnetic Resonance Imaging; Maps; Modeling; Myocardial; Pacemakers; Patients; Pattern; Predisposition; Recurrence; Research; Research Personnel; Resolution; Role; Speed; Testing; Tissues; Training; Transforming Growth Factor beta; Transgenic Organisms; Treatment outcome; base; career; density; ex vivo imaging; improved; in vivo; overexpression; skills; success

7. Project Summary Current treatments for persistent atrial fibrillation (AF) are associated with high recurrence rates due to our limited understanding of how AF develops and sustains. In patients with AF, structural remodeling in the form of fibrosis is often present, indicating that structural remodeling may have a role in AF development. This project aims to identify the role of fibrosis in AF by using a transgenic goat model. In aim 1, we strive to show the importance of structural remodeling compared to electrical remodeling in AF developing. In aim 2, the architecture of structural remodeling will be investigated to identify if differences in the underlying fibrotic architecture lead to increased AF susceptibility. In aim 3, the fibrotic architecture will be compared to in-vivo electrical mapping data to determine how varying degrees of fibrosis affect conduction patterns. The results of this project will investigate if there is a causal relationship between structural remodeling and impaired conduction. Success in this project will lead to improved ablation targets for patients with persistent AF, leading to lower recurrence rates. Completing this project provides valuable scientific and technical training to develop into an independent researcher.

7.项目摘要 目前持续性房颤（AF）的治疗与高复发率相关，这是由于我们的研究有限。 了解AF如何发展和维持。在房颤患者中，纤维化形式的结构重塑 通常存在，表明结构重塑可能在AF发展中起作用。该项目旨在 通过使用转基因山羊模型确定纤维化在AF中的作用。在目标1中，我们努力表明以下方面的重要性： 与电重构相比，房颤发展中的结构重构。在目标2中， 将研究重塑以确定潜在纤维化结构的差异是否导致增加的 房颤易感性。在目标3中，将纤维化结构与体内电标测数据进行比较， 确定不同程度的纤维化如何影响传导模式。该项目的结果将调查 结构重塑和传导受损之间是否存在因果关系。在这个项目中取得成功 将改善持续性房颤患者的消融靶点，降低复发率。 完成这个项目提供了宝贵的科学和技术培训，发展成为一个独立的 研究员