Mechanisms of inflammation-triggered taste loss and its recovery
炎症引发的味觉丧失及其恢复机制
基本信息
- 批准号:10211925
- 负责人:
- 金额:$ 35.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAnimal ModelAutoimmune DiseasesAutoimmunityBody Weight decreasedCOVID-19COVID-19 patientCell DeathCellsDiagnosisDiseaseDisease modelEpithelialEventExhibitsFunctional disorderFutureGoalsHealthHigh PrevalenceImmuneImmune systemInfectionInfiltrationInflammationInflammation ProcessInflammatoryInflammatory ResponseInjuryInterferonsInvadedInvestigationKnowledgeLeadLinkMalnutritionMediatingMental DepressionModelingMolecularMouse StrainsMusNatural regenerationPathway interactionsPatientsPerceptionPeriodicityPlayPositioning AttributePreventionProcessQuality of lifeReceptor CellRecoveryResearchResearch PersonnelResolutionRespiratory SystemRoleSARS-CoV-2 infectionSignal PathwaySignal TransductionSignaling MoleculeSymptomsTaste Bud CellTaste BudsTaste DisordersTaste PerceptionTestingTissuesToll-like receptorsTransgenic MiceTransgenic OrganismsViralViral Respiratory Tract InfectionVirus Diseasesclinically relevantcytokineeffective therapyexperienceimmune activationinfluenza infectioninfluenzavirusinsightnovel strategiespathogenpreventpublic health relevancereceptorrespiratory virusresponsestem cellstissue regenerationtissue repairtongue papilla
项目摘要
PROJECT SUMMARY
Taste loss can lead to malnutrition, weight loss, and depression. In addition, changes in taste are a symptom of
poor health. This cyclical relationship between taste and health highlights the importance of research aimed at
understanding taste loss in both health and disease. Research on taste loss will provide new approaches in the
prevention, diagnosis, and treatment of disease. It is well-documented that infections and autoimmune
conditions are accompanied by changes in chemosensory perception including changes in taste. However,
currently we know little about how taste bud regeneration is regulated, and there is no effective treatment for
taste loss. Our recent research indicates that inflammation, characterized by induction of inflammatory
cytokines and infiltration and activation of immune cells, contributes significantly to taste dysfunction. We
hypothesize that inflammation, particularly through the action of the inflammatory cytokine interferon-γ (IFN-γ),
contributes to taste loss by inducing cell death and inhibiting taste bud cell renewal, and that resolution of
inflammation promotes taste bud regeneration. IFN-γ can be produced by various types of immune and
nonimmune cells in response to infections and autoimmunity. Its levels in taste tissues are markedly increased
in an autoimmune disease model with taste loss. Yet, whether IFN-γ directly contributes to taste loss has not
been determined. In this project, we propose to investigate the role of inflammation, especially IFN-γ, in taste
loss using both a transgenic approach and a clinically relevant respiratory viral infection model. We will then
use these taste loss models to study the mechanisms of taste bud regeneration. This research will test
mechanistic hypotheses of how inflammation and infection cause taste loss, and how taste responses recover.
To underscore the importance of research investigating the link between inflammation, disease, and taste loss,
a considerable number of COVID-19 patients experience taste dysfunction. Although most cases of taste loss
are temporary, including taste loss associated with SARS-CoV-2 infection, long-term taste loss can occur in
some patients. Thus, insights from this research will be informative to better understand taste loss in general,
as well as taste loss associated with COVID-19.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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专利数量(0)
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Hong Wang其他文献
Hong Wang的其他文献
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{{ truncateString('Hong Wang', 18)}}的其他基金
Mechanisms of inflammation-triggered taste loss and its recovery
炎症引发的味觉丧失及其恢复机制
- 批准号:
10359837 - 财政年份:2021
- 资助金额:
$ 35.26万 - 项目类别:
Core 2: Biostatistics and Bioinformatics Core
核心2:生物统计学和生物信息学核心
- 批准号:
10469634 - 财政年份:2021
- 资助金额:
$ 35.26万 - 项目类别:
Core 2: Biostatistics and Bioinformatics Core
核心2:生物统计学和生物信息学核心
- 批准号:
10683755 - 财政年份:2021
- 资助金额:
$ 35.26万 - 项目类别:
Mechanisms of long-term taste loss in post-acute sequelae of COVID-19
COVID-19急性后遗症导致长期味觉丧失的机制
- 批准号:
10554842 - 财政年份:2021
- 资助金额:
$ 35.26万 - 项目类别:
Mechanisms of inflammation-triggered taste loss and its recovery
炎症引发的味觉丧失及其恢复机制
- 批准号:
10599864 - 财政年份:2021
- 资助金额:
$ 35.26万 - 项目类别:
Sequence and Structure Specific DNA Binding by Cohesin and Genome Stability
粘连蛋白的序列和结构特异性 DNA 结合以及基因组稳定性
- 批准号:
10175465 - 财政年份:2018
- 资助金额:
$ 35.26万 - 项目类别:
Mechanisms of inflammation-triggered taste loss and its recovery
炎症引发的味觉丧失及其恢复机制
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9527911 - 财政年份:2017
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HHcy-induced Inflammatory Monocyte and Macrophage Differentiation in Diabetes
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8969420 - 财政年份:2015
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