Mechanisms of inflammation-triggered taste loss and its recovery

炎症引发的味觉丧失及其恢复机制

基本信息

  • 批准号:
    10211925
  • 负责人:
  • 金额:
    $ 35.26万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-01 至 2026-03-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Taste loss can lead to malnutrition, weight loss, and depression. In addition, changes in taste are a symptom of poor health. This cyclical relationship between taste and health highlights the importance of research aimed at understanding taste loss in both health and disease. Research on taste loss will provide new approaches in the prevention, diagnosis, and treatment of disease. It is well-documented that infections and autoimmune conditions are accompanied by changes in chemosensory perception including changes in taste. However, currently we know little about how taste bud regeneration is regulated, and there is no effective treatment for taste loss. Our recent research indicates that inflammation, characterized by induction of inflammatory cytokines and infiltration and activation of immune cells, contributes significantly to taste dysfunction. We hypothesize that inflammation, particularly through the action of the inflammatory cytokine interferon-γ (IFN-γ), contributes to taste loss by inducing cell death and inhibiting taste bud cell renewal, and that resolution of inflammation promotes taste bud regeneration. IFN-γ can be produced by various types of immune and nonimmune cells in response to infections and autoimmunity. Its levels in taste tissues are markedly increased in an autoimmune disease model with taste loss. Yet, whether IFN-γ directly contributes to taste loss has not been determined. In this project, we propose to investigate the role of inflammation, especially IFN-γ, in taste loss using both a transgenic approach and a clinically relevant respiratory viral infection model. We will then use these taste loss models to study the mechanisms of taste bud regeneration. This research will test mechanistic hypotheses of how inflammation and infection cause taste loss, and how taste responses recover. To underscore the importance of research investigating the link between inflammation, disease, and taste loss, a considerable number of COVID-19 patients experience taste dysfunction. Although most cases of taste loss are temporary, including taste loss associated with SARS-CoV-2 infection, long-term taste loss can occur in some patients. Thus, insights from this research will be informative to better understand taste loss in general, as well as taste loss associated with COVID-19.
项目总结

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Hong Wang其他文献

Hong Wang的其他文献

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{{ truncateString('Hong Wang', 18)}}的其他基金

Mechanisms of inflammation-triggered taste loss and its recovery
炎症引发的味觉丧失及其恢复机制
  • 批准号:
    10359837
  • 财政年份:
    2021
  • 资助金额:
    $ 35.26万
  • 项目类别:
Core 2: Biostatistics and Bioinformatics Core
核心2:生物统计学和生物信息学核心
  • 批准号:
    10469634
  • 财政年份:
    2021
  • 资助金额:
    $ 35.26万
  • 项目类别:
Core 2: Biostatistics and Bioinformatics Core
核心2:生物统计学和生物信息学核心
  • 批准号:
    10683755
  • 财政年份:
    2021
  • 资助金额:
    $ 35.26万
  • 项目类别:
Mechanisms of long-term taste loss in post-acute sequelae of COVID-19
COVID-19急性后遗症导致长期味觉丧失的机制
  • 批准号:
    10554842
  • 财政年份:
    2021
  • 资助金额:
    $ 35.26万
  • 项目类别:
Mechanisms of inflammation-triggered taste loss and its recovery
炎症引发的味觉丧失及其恢复机制
  • 批准号:
    10599864
  • 财政年份:
    2021
  • 资助金额:
    $ 35.26万
  • 项目类别:
Sequence and Structure Specific DNA Binding by Cohesin and Genome Stability
粘连蛋白的序列和结构特异性 DNA 结合以及基因组稳定性
  • 批准号:
    10175465
  • 财政年份:
    2018
  • 资助金额:
    $ 35.26万
  • 项目类别:
CD40 monocyte in chronic kidney disease
CD40单核细胞在慢性肾脏病中的作用
  • 批准号:
    9331901
  • 财政年份:
    2017
  • 资助金额:
    $ 35.26万
  • 项目类别:
Mechanisms of inflammation-triggered taste loss and its recovery
炎症引发的味觉丧失及其恢复机制
  • 批准号:
    9527911
  • 财政年份:
    2017
  • 资助金额:
    $ 35.26万
  • 项目类别:
CD40 monocyte in chronic kidney disease
CD40单核细胞在慢性肾脏病中的作用
  • 批准号:
    9897533
  • 财政年份:
    2017
  • 资助金额:
    $ 35.26万
  • 项目类别:
HHcy-induced Inflammatory Monocyte and Macrophage Differentiation in Diabetes
HHcy 诱导的糖尿病炎症单核细胞和巨噬细胞分化
  • 批准号:
    8969420
  • 财政年份:
    2015
  • 资助金额:
    $ 35.26万
  • 项目类别:

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