Coord Core - Atkinson

基于我们多年来丰富的行政经验，包括监督多个多- 调查员/多机构/多学科的研究计划，我们相信一个强大的领导组成部分， 正如本协调核心所建议的那样，不仅是必要的.而且是至关重要的，以确保本协调核心的总体目标 符合U 54 NIH组织绘图中心（TMC）计划。在这种情况下，这样一个单位只是一个 人类生物分子图谱计划（HuBMAP）的一部分。我们相信， 在U 54中提出的协调核心是一个关键组成部分， U 54 TMC计划的计划目标和里程碑根据以下要求确定/优先考虑/修改： 所有这一切都是为了确保每一项都得到实现，目标得到实现。 同样重要的是，协调核心有效监督.并对 “连续移动部件”的数量;源自内部和外部资源的部件（例如， 其他TMC、HuBMAP研究者、HIVE）。本特定U 54 TMC提案中的实体，以及更大的 HuBMAP倡议将需要一定程度的管理技能/活动，从沟通到 资源配置、财政监督要科学协调，当然还要引导科学进步。 结果。虽然看起来很复杂，但我们要再次重申，根据我们的经验，我们有一个强大的 相信每一项活动都可以有很大的信心，并认为我们的 根据RFA-RM-17-027中的定义，为响应TMC倡议而提出的工作有能力做出 对HubMAB计划的总体目标产生重大影响。具体来说，我们认为自己提供了 行政服务，协调我们自己的TMC内的活动，与 其他TMC，以及对HuBMAP联盟以及更广泛的研究社区的数据贡献， 非常重要的努力。为了实现这一理念，我们提出了一个TMC协调核心， 目标1：协调联合国系统的财政和科学方面， U 54项目;目标2：促进项目内研究者之间的沟通;目标3：协调 关于方案进展和成功的持续反馈;以及目标4：目标4： 收集人力资源，生成适当的数据集，并促进项目结果的交流。 拟议的U 54的协调核心还将负责一些额外的通信 包括：1）与NIH的通信（例如，组织年度进展报告）; 2）提供材料 供人类机构审查委员会考虑; 3）与HuBMAP和HIVE的通信;以及4） 协助出版物和介绍方案成果。

Based on our extensive administrative experience over many years, including oversight to a number of multi- investigator / multi-institutional / multi-disciplinary research programs, we believe a strong leadership component, as proposed in this Coordination Core, is not just necessary…but essential to see that the overall goals of this U54 NIH Tissue Mapping Center (TMC) program are met. This, within the context that such a unit is but one component within the greater Human BioMolecular Atlas Program (HuBMAP) effort. Indeed, we believe the Coordination Core, proposed within this U54, represents a key component in terms of seeing that the programmatic goals and milestones for this U54 TMC program are established / prioritized / modified, according to a combination of needs and progress; all for the end purpose of seeing each achieved and the goals are met. Also central to this is the belief is the concept that the Coordination Core effectively oversees…and reacts to a number of “continuously moving parts”; both those emanating from internal as well as external resources (e.g., other TMC, HuBMAP investigators, HIVE). Entities within this specific U54 TMC proposal, as well as the greater HuBMAP initiative, will require a degree of management skills/activities ranging from communications to resource allocation, fiscal oversight to scientific coordination, and of course, guiding progress in scientific outcomes. While seemingly complex, we would again posit that based on our experience, we have a strong belief that each of these activities can be approached with a strong degree of confidence and contend that our proposed effort in response to this TMC initiative, as defined in RFA-RM-17-027, has the ability to make a significant impact towards the overall goals of the HubMAB program. Specifically, we see ourselves as providing the administrative services, coordination of activities within our own TMC, sharing of expertise/resources with other TMCs, and contributions of data to the HuBMAP consortium as well as the wider research community as exceedingly important efforts. To achieve this notion, we pose a TMC Coordination Core that would be set forward to achieve the following four Specific Aims: Aim 1: Coordinate the fiscal and scientific aspects of the U54 program; Aim 2: Facilitate communication among investigators within the program; Aim 3: Coordinate ongoing feedback with regard to the progress and success of the program; and Aim 4: Aim 4: Organize the collection of human materials, generate appropriate data sets, and facilitate communication of program results. The Coordination Core of this proposed U54 will also be responsible for a number of additional communications including: 1) communications with the NIH (e.g., organizing the annual progress reports); 2) providing materials for Human Institutional Review Board considerations; 3) communications with the HuBMAP and HIVE; and 4) assistance with publications and presentation of program results.