Translational Research to Inform Interventions for Severe Challenging Behavior for Individuals with Intellectual and Developmental Disabilities

转化研究为智力和发育障碍人士的严重挑战行为干预提供信息

• 批准号: 10214304
• 负责人: Joseph Michael Lambert
• 金额: $ 6.8万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10214304
• 关键词: Abate; Address; Adult; Affect; Beavers; Behavior; Complex; Consumption; Developmental Disabilities; Disabled Persons; Enrollment; Environment; Extinction (Psychology); Funding Mechanisms; Goals; Individual; Intellectual functioning disability; Intervention; Investigation; Logic; Mental Health; National Institute of Child Health and Human Development; Outcome; Output; Participant; Prevalence; Price; Procedures; Process; Psychological reinforcement; Randomized; Recording of previous events; Reinforcement Schedule; Research; Research Personnel; Resources; Schedule; Self-Injurious Behavior; Services; Testing; Therapeutic; Translational Research; behavioral health; clinical care; consumer demand; design; effective intervention; falls; improved; insight; physical conditioning; reinforcer; response; theories; therapy development; therapy outcome

PROJECT SUMMARY This R03 resubmission proposes to evaluate whether the extinction bursts (i.e., temporary increases in rate or intensity of behavior during extinction) of individuals with intellectual and developmental disabilities (IDD) can be mitigated through systematic assessment and intervention. This project addresses a critical need in the assessment and treatment of severe challenging behavior for individuals with IDD because extinction is often a necessary component of effective intervention but the potential for bursts precludes its use in environments that cannot support escalations (e.g., public spaces). The Goal of this application is to identify mechanisms responsible for bursts, and to facilitate strategic extensions toward discovery for treatments of challenging behavior. AIM 1: In the service of this goal, we aim to evaluate the accuracy of an efficient alternative to demand-curve analysis (i.e., progressive ratio reinforcer analysis) in quantifying reinforcer value (i.e., Pmax). AIM 2: We also aim to evaluate the utility of manipulating baseline reinforcement parameters for controlling bursts when those manipulations are informed by the results of demand-curve analysis (AIM 2). We will enroll 80 adults with developmental disabilities in a low-stakes translational investigation employing a 2x2 factorial, crossed, and randomized matched blocks design, with batched randomization logic. Procedures will include: (a) conducting progressive ratio and progressive-fixed ratio reinforcer analyses for each study participant (AIM 1), and (b) randomly assigning each participant to one of four experimental conditions to determine whether information about reinforcer value can be used to set baseline parameters that either promote or eliminate bursts during extinction (AIM 2). This project aligns with objectives of the Intellectual and Developmental Disabilities Branch (IDDB) of the National Institute of Child Health and Human Development (NICHD) because it contributes to understanding of factors that facilitate efficient elimination of severe challenging behavior and promotes the development of treatments which can improve the behavioral health, clinical care, and qualities of lives of individuals with IDD. Specifically, the outcomes of this project promise to provide insight into the ways in which researchers can mitigate the undesirable collateral effects (i.e., extinction bursts) of therapeutic action (i.e., extinction) against severe challenging behavior. This project is appropriate for the R03 funding mechanism because it is a clearly defined study that can be completed in two years, with limited resources.

项目摘要 此R03重新提议建议评估灭绝是否爆发（即暂时增加 智力和发育障碍的个体（IDD）的灭绝期间行为的速度或强度 可以通过系统的评估和干预来缓解。该项目满足了关键需求 对IDD患者的严重挑战行为的评估和处理，因为灭绝是 通常是有效干预的必要组成部分，但爆发的潜力排除了其在 无法支持升级的环境（例如，公共空间）。 该应用的目的是确定负责爆发的机制，并促进战略 扩展到发现挑战行为的疗法。目标1：为了实现这一目标，我们的目标 评估需求曲线分析的有效替代方案的准确性（即渐进式增强剂 分析）在量化增强器值（即PMAX）中。目标2：我们还旨在评估操纵的实用性 当这些操作被结果告知时，用于控制爆发的基线加固参数 需求曲线分析（AIM 2）。 我们将在低风险转化调查中注册80名发育障碍的成年人 采用2x2阶乘，交叉和随机匹配的块设计，并进行批处理随机化 逻辑。程序将包括：（a）进行渐进比率和渐进式固定比率增强器分析 对于每个研究参与者（AIM 1），以及（b）将每个参与者随机分配给四个实验之一 确定是否可以使用有关增强剂值的信息来设置基线参数 在灭绝期间促进或消除爆发（AIM 2）。 该项目与智力和发展障碍分支（IDDB）的目标保持一致 美国国家儿童健康与人类发展研究所（NICHD），因为它有助于 了解有效消除严重挑战行为的因素，并促进 开发可以改善行为健康，临床护理和生活素质的治疗方法 患有IDD的人。具体而言，该项目的结果承诺将洞悉 研究人员可以减轻治疗作用的不良抵押作用（即灭绝爆发）（即 灭绝）反对严重的挑战行为。该项目适合R03资金机制 因为这是一项明确定义的研究，可以在两年内完成，资源有限。