Translational Research to Inform Interventions for Severe Challenging Behavior for Individuals with Intellectual and Developmental Disabilities

转化研究为智力和发育障碍人士的严重挑战行为干预提供信息

• 批准号: 10397114
• 负责人: Joseph Michael Lambert
• 金额: $ 6.81万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10397114
• 关键词: Abate; Address; Adult; Affect; Beavers; Behavior; Complex; Consumption; Developmental Disabilities; Disabled Persons; Enrollment; Environment; Extinction (Psychology); Funding Mechanisms; Goals; Individual; Intellectual functioning disability; Intervention; Investigation; Logic; Mental Health; National Institute of Child Health and Human Development; Outcome; Output; Participant; Prevalence; Price; Procedures; Process; Psychological reinforcement; Randomized; Recording of previous events; Reinforcement Schedule; Research; Research Personnel; Resources; Schedule; Self-Injurious Behavior; Services; Testing; Therapeutic; Translational Research; behavioral health; clinical care; consumer demand; design; effective intervention; falls; improved; insight; physical conditioning; reinforcer; response; theories; therapy development; therapy outcome

PROJECT SUMMARY This R03 resubmission proposes to evaluate whether the extinction bursts (i.e., temporary increases in rate or intensity of behavior during extinction) of individuals with intellectual and developmental disabilities (IDD) can be mitigated through systematic assessment and intervention. This project addresses a critical need in the assessment and treatment of severe challenging behavior for individuals with IDD because extinction is often a necessary component of effective intervention but the potential for bursts precludes its use in environments that cannot support escalations (e.g., public spaces). The Goal of this application is to identify mechanisms responsible for bursts, and to facilitate strategic extensions toward discovery for treatments of challenging behavior. AIM 1: In the service of this goal, we aim to evaluate the accuracy of an efficient alternative to demand-curve analysis (i.e., progressive ratio reinforcer analysis) in quantifying reinforcer value (i.e., Pmax). AIM 2: We also aim to evaluate the utility of manipulating baseline reinforcement parameters for controlling bursts when those manipulations are informed by the results of demand-curve analysis (AIM 2). We will enroll 80 adults with developmental disabilities in a low-stakes translational investigation employing a 2x2 factorial, crossed, and randomized matched blocks design, with batched randomization logic. Procedures will include: (a) conducting progressive ratio and progressive-fixed ratio reinforcer analyses for each study participant (AIM 1), and (b) randomly assigning each participant to one of four experimental conditions to determine whether information about reinforcer value can be used to set baseline parameters that either promote or eliminate bursts during extinction (AIM 2). This project aligns with objectives of the Intellectual and Developmental Disabilities Branch (IDDB) of the National Institute of Child Health and Human Development (NICHD) because it contributes to understanding of factors that facilitate efficient elimination of severe challenging behavior and promotes the development of treatments which can improve the behavioral health, clinical care, and qualities of lives of individuals with IDD. Specifically, the outcomes of this project promise to provide insight into the ways in which researchers can mitigate the undesirable collateral effects (i.e., extinction bursts) of therapeutic action (i.e., extinction) against severe challenging behavior. This project is appropriate for the R03 funding mechanism because it is a clearly defined study that can be completed in two years, with limited resources.

项目摘要 本次R03重新提交建议评估消光爆发（即，临时增加 智力和发育障碍（IDD）个体在灭绝过程中的行为速度或强度） 可以通过系统的评估和干预来缓解。该项目解决了以下方面的关键需求： 评估和治疗IDD患者的严重挑战行为，因为灭绝是 通常是有效干预的必要组成部分，但爆发的可能性排除了其在 不能支持升级的环境（例如，公共空间）。 该应用程序的目标是确定负责突发的机制，并促进战略 对挑战性行为的治疗方法的探索。目标1：为了实现这一目标，我们的目标是 为了评估需求曲线分析的有效替代方案的准确性（即，累进比计数器 分析）在量化器值（即，Pmax）。目的2：我们还旨在评估操纵的效用 当这些操作被结果告知时，用于控制爆发的基线强化参数 需求曲线分析（AIM 2）。 我们将招募80名患有发育障碍的成年人参加一项低风险的转化研究 采用2x2析因、交叉和随机匹配区组设计，采用分批随机化 逻辑程序将包括：（a）进行累进比率和累进固定比率分析 对于每个研究参与者（AIM 1），以及（B）将每个参与者随机分配到四个实验组之一， 用于确定是否可以使用有关设置器值的信息来设置基线参数的条件 促进或消除消光过程中的爆发（AIM 2）。 该项目符合《残疾人权利公约》智力和发育残疾分支的目标。 国家儿童健康和人类发展研究所（NICHD），因为它有助于 了解有助于有效消除严重挑战行为并促进 开发治疗方法，可以改善行为健康，临床护理和生活质量， IDD患者。具体而言，该项目的成果有望提供深入了解的方式， 研究人员可以减轻不希望的附带影响（即，消退爆发）的治疗作用（即， 灭绝）对严重的挑战行为。本项目适合R03供资机制 因为这是一项清晰界定的研究，可以在两年内完成，而资源亦有限。