Translational Research to Inform Interventions for Severe Challenging Behavior for Individuals with Intellectual and Developmental Disabilities

项目总结 本R03重新提交建议评估物种灭绝是否突然爆发(即 智力和发育障碍(IDD)个体的行为速度或强度) 可以通过系统的评估和干预来缓解。该项目解决了以下关键需求 IDD患者严重挑战行为的评估和治疗，因为灭绝是 通常是有效干预的必要组成部分，但潜在的突发事件使其无法在 无法支持升级的环境(例如，公共空间)。 此应用程序的目标是确定突发事件的责任机制，并促进战略 向发现具有挑战性的行为的治疗延伸。目标1：为了实现这个目标，我们的目标是 评估需求曲线分析的有效替代方法(即累进比率增强器)的准确性 分析)在量化增强剂值(即，Pmax)中。目标2：我们还旨在评估操纵的实用性 当结果通知这些操作时，用于控制爆破的基线钢筋参数 需求曲线分析(目标2)。 我们将招募80名有发育障碍的成年人参加一项低风险的翻译调查 采用2x2析因法、交叉法和随机化匹配区组设计，分批随机化 这是逻辑。程序将包括：(A)进行累进比率和累进-固定比率增强剂分析 对于每个研究参与者(目标1)，以及(B)将每个参与者随机分配到四个实验之一 用于确定有关增强器值的信息是否可用于设置基线参数的条件 在物种灭绝期间促进或消除爆发的生物(目标2)。 该项目与#年智力和发展障碍处(IDDB)的目标一致。 国家儿童健康与人类发展研究所(NICHD)，因为它有助于 了解有助于有效消除严重挑战行为的因素并促进 开发可改善行为健康、临床护理和生活质量的治疗方法 患有IDD的个体。具体地说，该项目的成果承诺提供对以下方面的洞察 研究人员可以减轻治疗行动(即， 灭绝)来对抗严重的挑战行为。本项目适用于R03资助机制 因为这是一项定义明确的研究，可以在两年内完成，资源有限。

PROJECT SUMMARY This R03 resubmission proposes to evaluate whether the extinction bursts (i.e., temporary increases in rate or intensity of behavior during extinction) of individuals with intellectual and developmental disabilities (IDD) can be mitigated through systematic assessment and intervention. This project addresses a critical need in the assessment and treatment of severe challenging behavior for individuals with IDD because extinction is often a necessary component of effective intervention but the potential for bursts precludes its use in environments that cannot support escalations (e.g., public spaces). The Goal of this application is to identify mechanisms responsible for bursts, and to facilitate strategic extensions toward discovery for treatments of challenging behavior. AIM 1: In the service of this goal, we aim to evaluate the accuracy of an efficient alternative to demand-curve analysis (i.e., progressive ratio reinforcer analysis) in quantifying reinforcer value (i.e., Pmax). AIM 2: We also aim to evaluate the utility of manipulating baseline reinforcement parameters for controlling bursts when those manipulations are informed by the results of demand-curve analysis (AIM 2). We will enroll 80 adults with developmental disabilities in a low-stakes translational investigation employing a 2x2 factorial, crossed, and randomized matched blocks design, with batched randomization logic. Procedures will include: (a) conducting progressive ratio and progressive-fixed ratio reinforcer analyses for each study participant (AIM 1), and (b) randomly assigning each participant to one of four experimental conditions to determine whether information about reinforcer value can be used to set baseline parameters that either promote or eliminate bursts during extinction (AIM 2). This project aligns with objectives of the Intellectual and Developmental Disabilities Branch (IDDB) of the National Institute of Child Health and Human Development (NICHD) because it contributes to understanding of factors that facilitate efficient elimination of severe challenging behavior and promotes the development of treatments which can improve the behavioral health, clinical care, and qualities of lives of individuals with IDD. Specifically, the outcomes of this project promise to provide insight into the ways in which researchers can mitigate the undesirable collateral effects (i.e., extinction bursts) of therapeutic action (i.e., extinction) against severe challenging behavior. This project is appropriate for the R03 funding mechanism because it is a clearly defined study that can be completed in two years, with limited resources.