In vivo insights of small vessel changes with age using USPIO-enhanced MRI

使用 USPIO 增强 MRI 观察小血管随年龄变化的体内变化

• 批准号: 10213150
• 负责人: Yulin Ge
• 金额: $ 74.93万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213150
• 关键词: 3-Dimensional; Adult; Affect; Age; Aging; Anatomy; Animals; Architecture; Area; Arteries; Arteriogram; Atlases; Autopsy; Basal Ganglia; Blood; Blood Circulation; Blood Vessels; Blood capillaries; Brain; Brain imaging; Caliber; Cerebrum; Clinical; Contrast Media; Data; Dementia; Detection; Diagnostic; Disease; Dose; Echo-Planar Imaging; Erythrocytes; Event; Extravasation; Female; Gender; Glucose; Goals; Health; Human; Image; Imaging Device; Impaired cognition; Iron; Life Cycle Stages; Longevity; Magnetic Resonance Imaging; Maps; Measures; Medical; Metabolic; Methods; Morphology; Neurodegenerative Disorders; Oxygen; Pathologic; Pathology; Physics; Physiological Processes; Play; Predisposition; Protocols documentation; Resolution; Risk Factors; Scanning; Site; Source; Speed; Stenosis; Structure; System; Techniques; Time; Tissues; Veins; Venous; Venous system; Visual; age related; aged; aging brain; arteriole; base; cerebral artery; cohort; density; experimental study; ferumoxtran; ferumoxytol; follow-up; frontal lobe; healthy volunteer; human subject; image processing; image reconstruction; improved; in vivo; innovative technologies; insight; interest; macrovascular disease; male; nervous system disorder; neuropathology; neurovascular; normal aging; novel; simulation; ultra high resolution; venule; volunteer; white matter

Project Summary / Abstract: The microvascular arterial system plays a key role in delivering oxygen and glucose to fulfill the high metabolic demand of the brain. Recently, microvascular abnormalities have been increasingly identified as the source or basis of many neurologic disorders including age-related dementia. Today, the mechanisms of both structural and functional changes due to aging are still largely unclear, and there is an urgent need for in vivo characterization as to how small vessel ages over the life course in both male and female adults. Although MRI is able to image the structural aspects of the brain with a resolution of 1mm today, it has not yet been used to study microvascular details in humans in vivo at the in-plane resolution of 100μm or less. We have developed a means by which to modify the susceptibility of the arteries using an ultra-small-superparamagnetic-iron-oxide (USPIO) to make it possible to image both small arteries and veins with susceptibility weighted imaging (SWI) and quantitative susceptibility mapping (QSM) to see micro vessels less than 100μm. Our interest in this proposal is to bring together experts in a variety of medical and scientific areas such as MR physics, image processing and reconstruction to develop a new technique which we refer to ultra-high resolution USPIO-enhanced MR arteriogram and venogram (USPIO+-MRAV). We will take advantage of the blooming effect from the USPIO and the shift in susceptibility to create new means to image both arterioles and venules at the 50μm to 100μm level on both 3T and 7T MRI scanners. We expect to have a clinically viable method to create a “microvascular print” of the brain's angio-architecture based on 3D vascular tracking to assess micro-vessel topology and distribution that are not available on conventional imaging. We will develop quantitative measures of vascular density and capillary density to evaluate age-related changes in a cohort of healthy volunteers aged from 18 to 85 years. If successful, this innovative technology is expected to provide fundamental insights on how age-related microvascular alteration is detected and interpreted with in vivo brain imaging.

项目摘要/摘要：微血管动脉系统在输送氧气和 葡萄糖以满足大脑的高代谢需求。近年来，微血管异常 越来越多地被认为是许多神经系统疾病（包括与年龄相关的痴呆症）的根源或基础。 如今，衰老引起的结构和功能变化的机制仍不清楚，并且 迫切需要对小血管在生命过程中如何老化进行体内表征 男性和女性成人。尽管 MRI 能够以分辨率对大脑结构进行成像 目前为 1mm，尚未用于以面内分辨率研究人体体内的微血管细节 100μm以下。我们开发了一种方法来改变动脉的敏感性 超小型超顺磁性氧化铁 (USPIO) 使小动脉和静脉成像成为可能 通过磁化率加权成像 (SWI) 和定量磁化率测绘 (QSM) 来观察微血管 小于100μm。我们对这项提案的兴趣是汇集各种医学和科学领域的专家 MR物理、图像处理和重建等领域开发了一种新技术，我们称之为 超高分辨率 USPIO 增强 MR 动脉造影和静脉造影 (USPIO+-MRAV)。我们将采取 利用 USPIO 的开花效应和敏感性的转变来创建新的成像方法 在 3T 和 7T MRI 扫描仪上显示 50μm 至 100μm 水平的小动脉和小静脉。我们期望有一个 临床上可行的方法，基于 3D 血管创建大脑血管结构的“微血管打印” 跟踪以评估传统成像无法实现的微血管拓扑和分布。我们 将开发血管密度和毛细血管密度的定量测量方法，以评估与年龄相关的变化 一组年龄在 18 岁到 85 岁之间的健康志愿者。如果成功，这项创新技术预计将 提供关于如何检测和解释与年龄相关的微血管改变的基本见解 体内脑成像。