Reconfigurable MRI technology for safe and high-resolution imaging of deep brain stimulation at 3T

可重构 MRI 技术,可在 3T 下对深部脑刺激进行安全且高分辨率的成像

基本信息

  • 批准号:
    10217692
  • 负责人:
  • 金额:
    $ 55.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-15 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

Project Summary Deep brain stimulation (DBS) is a neurosurgical procedure that involves implanting electrodes into specific areas within the brain and delivering constant or intermittent electric pulses from an implanted pulse generator (IPG) to modulate neural function. DBS is the gold standard treatment for Parkinson’s disease, and has shown promise in treating other disorders, most notably chronic pain, epilepsy, major depression, and Alzheimer’s disease. Magnetic resonance imaging (MRI) is extremely useful in patients with DBS implants, as it can provide information on precise location of implanted electrodes and functional response to stimulation. Unfortunately, the interaction of radiofrequency (RF) fields generated by MRI scanners with the leads of DBS devices can trigger potentially fatal RF heating within the tissue. This means that current MRI technology is inaccessible to most patients with DBS implants, presenting a significant barrier to progress in the field of DBS therapeutics. This project seeks to develop novel MRI methodologies alongside DBS implantation techniques that together will make cutting-edge MRI technology fully compatible with implanted DBS devices. Here, this two-pronged approach takes the form of (1) building on our recently introduced concept of reconfigurable MRI technology; and (2) establishing surgical guidelines specific to DBS device implantation. Reconfigurable MRI technology is based on the idea that through innovative engineering we can control local electric fields generated by MR on a patient-by-patient basis, thus avoiding interactions with an implanted device, wherever it happens to be. Part and parcel with engineering-based solutions, we recognize the importance of DBS device lead placement in optimizing the success of the reconfigurable MRI approach. Although RF heating depends exquisitely on lead-trajectory, surgical guidelines are completely silent as to how to best place the extracranial portion of the leads. This in turn leads to arbitrary (and highly variable) lead positioning, which can make RF heating unpredictable even when using reconfigurable technology. Thus, we propose work to develop and validate novel MR technology (Aim 1), intra-surgical implantation strategies (Aim 2), and simulation-based, patient-specific approaches to defining safe imaging parameters (Aim 3). Together, these efforts will eliminate RF heating, reduce image artifact, and support the use of next generation MRI in patients with DBS implants. Our team includes experts in MRI hardware development and instrumentation, MRI computational modeling and safety assessment, FDA regulatory scientists, DBS clinical management and neurosurgery, as well as collaborators from DBS device industry. If successful, we will bring state-of-the-art 3T MRI to DBS patients in its full capacity. This will allow for methodical analysis of DBS parameters/targets in emerging applications, improve our understanding of DBS in existing indications, and bring standard-of-care imaging to patients with existing DBS implants.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Laleh Golestani Rad其他文献

Laleh Golestani Rad的其他文献

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{{ truncateString('Laleh Golestani Rad', 18)}}的其他基金

Novel MRI coil technology for safe imaging of children with implants
新型 MRI 线圈技术可对植入儿童进行安全成像
  • 批准号:
    10639661
  • 财政年份:
    2023
  • 资助金额:
    $ 55.64万
  • 项目类别:
Assessing RF heating of active implantable medical devices in low-field MRI system
评估低场 MRI 系统中有源植入式医疗设备的射频加热
  • 批准号:
    10564463
  • 财政年份:
    2022
  • 资助金额:
    $ 55.64万
  • 项目类别:
Assessing RF heating of active implantable medical devices in low-field MRI system
评估低场 MRI 系统中有源植入式医疗设备的射频加热
  • 批准号:
    10709014
  • 财政年份:
    2022
  • 资助金额:
    $ 55.64万
  • 项目类别:
Reconfigurable MRI technology for safe and high-resolution imaging of deep brain stimulation at 3T
可重构 MRI 技术,可在 3T 下对深部脑刺激进行安全且高分辨率的成像
  • 批准号:
    10445316
  • 财政年份:
    2021
  • 资助金额:
    $ 55.64万
  • 项目类别:
Reconfigurable MRI technology for safe and high-resolution imaging of deep brain stimulation at 3T
可重构 MRI 技术,可在 3T 下对深部脑刺激进行安全且高分辨率的成像
  • 批准号:
    10654726
  • 财政年份:
    2021
  • 资助金额:
    $ 55.64万
  • 项目类别:
Safety assessment of magnetic resonance imaging in patients with retained cardiac leads
保留心脏导线患者的磁共振成像安全性评估
  • 批准号:
    9762904
  • 财政年份:
    2018
  • 资助金额:
    $ 55.64万
  • 项目类别:
Patient-adjustable MRI technology for high-resolution imaging of deep brain stimulation
用于深部脑刺激高分辨率成像的患者可调 MRI 技术
  • 批准号:
    9179807
  • 财政年份:
    2016
  • 资助金额:
    $ 55.64万
  • 项目类别:
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