Novel MRI coil technology for safe imaging of children with implants

新型 MRI 线圈技术可对植入儿童进行安全成像

• 批准号: 10639661
• 负责人: Laleh Golestani Rad
• 金额: $ 58.2万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10639661
• 关键词: 3-Dimensional; 6 year old; Acceleration; Accounting; Adult; Age; Biophysics; Body Size; Brain imaging; Brain scan; Cardiac; Cardiovascular system; Central Nervous System; Child; Childhood; Clinical; Coiled Bodies; Couples; Devices; Electrodes; Electronics; Engineering; Exclusion; FDA approved; Fever; Head; Heating; Helmet; History of Medicine; Human; Human Biology; Human Pathology; Image; Implant; Individual; Industrialization; Infant; Injury; Intervention; Investments; Knowledge; Location; Magnetic Resonance Imaging; Manufacturer; Maps; Marketing; Mechanics; Methodology; Motion; Nervous System; Pathology; Patients; Pediatric Radiology; Pediatric Surgical Procedures; Performance; Phase; Research; Resolution; Resources; Risk; Rotation; Safety; Scientific Inquiry; Severities; Slice; System; Techniques; Technology; Tissues; Vendor; Vulnerable Populations; Work; absorption; cardiac implant; case-by-case basis; design; electric field; flexibility; heart imaging; implantable device; improved; industry partner; innovation; instrumentation; interest; multidisciplinary; novel; patient safety; pediatric patients; radio frequency; safety assessment; standard of care; transmission process; vagus nerve stimulation; virtual

Abstract Magnetic resonance imaging (MRI) has revolutionized our approach to understanding human biology and pathology. Despite continuous advances, however, MRI remains largely inaccessible to a sizeable and growing group of patients who have conductive implants. The problem is exacerbated in children, for whom MR- conditional devices are not readily available, leaving this vulnerable population unable to receive the standard of care that they need the most, and excluding them from scientific inquiries when they are most advantageous. The major risk of MRI in patients with conductive implants is the RF heating of the tissue due to the antenna effect. This happens when the electric field of MRI scanner couples with the implanted device and amplifies the specific absorption rate (SAR) of the radiofrequency energy in the tissue surrounding the implant. MR-conditional implants have been approved by the FDA for adults, allowing patients to receive MRI under restricted conditions that assure safety. Regrettably, however, neither MRI vendors nor device manufacturers have established safe MRI methodologies for children with conductive implants. We propose to develop, validate, and deploy a novel multi-platform MRI coil technology that allows ultra-fast and high-resolution MRI to be safely performed in children with conductive implants regardless of the implant location in their bodies. Our solution is based on the idea that through innovative engineering we can control local electric fields generated by MRI on a case-by-case basis, thus avoiding interactions with the individual's implanted device wherever it happens to be in the body. Our preliminary results show that this technique can achieve a 20- fold reduction in RF heating of cardiac implantable electronic devices (CEIDs), as well as implants of central nervous system (CNS) such as EcoG electrodes and Vagus Nerve Stimulation (VNS) devices. Such reduction in RF heating is sufficient to support all clinical and research sequences of interest in brain and body imaging. Here we propose to take this proof-of-concept to the next level and develop, implement, validate, and deploy the first reconfigurable patient-adjustable (RPA) MRI coil technology tailored for imaging infants and young children. Specifically, we propose to 1) Develop and validate a patient-adjustable rotating MRI transmit coil that eliminates RF heating in children with cardiac and CNS implants, and 2) Develop age-optimized close-fitting head and body receive arrays that integrate with the rotating coil and determine the range of imaging parameters that allow safe deployment of the ensemble coil system in children with implants. We are a multidisciplinary team including experts in MRI biophysics, instrumentation, and safety assessment, clinicians with expertise and resources in pediatric radiology and pediatric surgery, as well as MRI vendors and industry partners. If successful, our work brings state-of-the-art MRI accessible to children with implants. This will allow methodical analysis of device parameters in emerging applications, improve our understanding of existing indications, and brings unrestricted standard-of-care to pediatric patients with devices.

摘要 磁共振成像（MRI）彻底改变了我们理解人类生物学的方法， 病理然而，尽管不断取得进展，MRI仍然在很大程度上无法进入相当大的和不断增长的 一组植入导电植入物的患者。这个问题在儿童中更为严重，对他们来说，MR- 有条件的设备不容易获得，使这一弱势群体无法获得标准的医疗服务。 关心他们最需要的，并在他们最有利的时候将他们排除在科学调查之外。 植入导电植入物的患者接受MRI的主要风险是天线导致的组织射频加热 效果当MRI扫描仪的电场与植入设备耦合并放大 植入物周围组织中射频能量的比吸收率（SAR）。mr特定 植入物已被FDA批准用于成人，允许患者在限制条件下接受MRI检查 确保安全。然而，遗憾的是，无论是MRI供应商还是设备制造商都没有建立安全的 植入导电植入物的儿童的MRI方法。 我们建议开发、验证和部署一种新的多平台MRI线圈技术， 在植入导电植入物的儿童中安全进行高分辨率MRI，无论植入位置如何 在他们的身体里。我们的解决方案是基于这样的想法，通过创新的工程，我们可以控制当地的电力 MRI产生的磁场，从而避免与个体植入的 设备，无论它发生在身体的任何地方。我们的初步结果表明，这项技术可以实现20- 心脏植入式电子设备（CEID）以及中央心脏植入物的射频发热减少1倍 神经系统（CNS），例如EcoG电极和迷走神经刺激（VNS）装置。这种减少 RF加热足以支持大脑和身体成像中感兴趣的所有临床和研究序列。 在这里，我们建议将此概念验证提升到下一个级别，并开发、实现、验证和部署 第一个可重新配置的患者可调（RPA）MRI线圈技术，专为婴儿和幼儿成像而设计。 具体而言，我们建议：1）开发并验证患者可调节的旋转MRI发射线圈， 植入心脏和CNS植入物的儿童中的射频致热，以及2）开发年龄优化的紧密贴合头部和身体 接收阵列与旋转线圈集成，并确定成像参数的范围， 在植入植入物的儿童中部署整体弹簧圈系统。 我们是一个多学科团队，包括MRI生物物理学、仪器和安全评估方面的专家， 拥有儿科放射学和儿科外科专业知识和资源的临床医生，以及MRI供应商， 行业合作伙伴。如果成功的话，我们的工作将为植入物的儿童带来最先进的MRI。这 将允许在新兴应用中对器件参数进行系统分析，提高我们对 现有适应症，并为使用器械的儿科患者带来不受限制的标准治疗。