Inflammatory trajectories across pregnancy: Investigating novel markers of risk for postpartum depression
整个怀孕期间的炎症轨迹:研究产后抑郁症风险的新标志物
基本信息
- 批准号:10217881
- 负责人:
- 金额:$ 24.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-20 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdverse effectsAffectAnti-Inflammatory AgentsAreaAutomobile DrivingBehaviorBiological AssayBiological MarkersBiological ProcessBlood specimenCOVID-19 pandemicChildChildbirthCognitionComplexDevelopmentDiagnosisEarly identificationEtiologyFetal DevelopmentFetusFoundationsFutureGoalsImmuneImmune systemImmunologic MarkersImmunological ModelsImmunologicsImpairmentIndividual DifferencesInflammationInflammatoryInvestigationKnowledgeLinkLongitudinal StudiesMaintenanceMental DepressionMental disordersMethodologyModelingMothersNeurobiologyParentsPersonsPlasmaPostpartum DepressionPostpartum PeriodPregnancyPregnancy TrimestersPregnant WomenPreventionProcessPublic HealthResearchRiskRisk FactorsRisk MarkerRoleSamplingSignal TransductionSpecificitySymptomsTestingTherapeutic InterventionTimeWomanWorkantepartum depressionclinical biomarkerscytokinedepressive symptomsexperienceimmunoregulationinflammatory markerinsightintergenerationallongitudinal designmaternal caregivingmaternal depressionmood symptomnovelnovel markerperinatal periodpostnatalprenatalpreventprospectivesuicidal risk
项目摘要
Project Summary
Postpartum depression (PPD) is the most common form of psychiatric illness occurring after childbirth, affecting
nearly 18% of women globally and contributing to suffering and impaired functioning in both mothers and their
children. To elucidate factors that contribute to PPD risk, the current project seeks to test the role of inflammatory
markers across pregnancy in the prediction of postpartum depressive symptoms. Specifically, reflecting recent
theoretical work on the complex and shifting role of the immune system during pregnancy, the current project
will utilize a prospective longitudinal design of 165 pregnant women to examine dynamic trajectories of
inflammatory markers across pregnancy in the prediction of PPD symptoms and diagnosis at one- and two-
months postpartum. Through repeated assessments across the prenatal and postpartum periods, by considering
potentially curvilinear trajectories of inflammatory markers instead of single assessments, and by examining a
range of immunological markers simultaneously, we will overcome past roadblocks to progress and more closely
mirror the alternating immunological priorities of pregnancy. Leveraging stored plasma samples collected prior
to the COVID-19 pandemic as part of a parent R01 study of depressive symptoms during pregnancy
(MH109662), this work will characterize trajectories of key depression-relevant inflammatory markers across
each trimester of pregnancy in women with and without elevated prenatal depressive symptoms (Aim 1) and
examine whether inflammatory trajectories prospectively predict depressive symptoms and PPD diagnosis at
one- and two-months postpartum (Aim 2). As well, it will probe the predictive specificity of depression-relevant
inflammatory markers (versus shifts in Th1 and Th2 cytokines or inflammatory markers implicated in other
psychiatric disorders) and will explore whether inflammatory profiles in pregnancy differentially relate to certain
PPD symptoms (Aim 3). Through this methodologically rigorous approach, we will be poised to conduct strong
tests of directional associations between prenatal inflammation and postpartum depressive symptoms and to
identify inflammatory parameters that may serve as risk biomarkers. In doing so, insights from this project will
be critical for advancing future hypotheses to elucidate the precise neurobiological cascades that account for
links between inflammation and postpartum depressive symptoms, with the ultimate goal to identify novel factors
to target in the prevention or treatment of postpartum depression.
项目摘要
产后抑郁症(PPD)是产后最常见的精神疾病,影响
全球近18%的妇女造成母亲和母亲的痛苦和功能受损
孩子们。为了阐明导致产后抑郁风险的因素,目前的项目试图测试炎症的作用。
孕期标志物在预测产后抑郁症状中的作用。具体来说,反映了最近
目前的项目是关于怀孕期间免疫系统复杂和变化的作用的理论工作
将利用对165名孕妇的前瞻性纵向设计来检查
妊娠期炎性标志物在预测PPD症状和诊断中的作用
产后几个月。通过对产前和产后的反复评估,通过考虑
炎症标志物的潜在曲线轨迹,而不是单一的评估,并通过检查
一系列免疫标志物的同时,我们将克服过去取得进展的障碍,并更加紧密地
反映孕期免疫优先顺序的交替变化。利用之前收集的存储的血浆样本
作为父母R01对妊娠期抑郁症状研究的一部分,新冠肺炎大流行
(MH109662),这项工作将表征与抑郁症相关的关键炎症标志物的轨迹
妊娠每三个月有和没有产前抑郁症状升高的妇女(目标1)和
检查炎症轨迹是否可预测抑郁症状和PPD的诊断
产后一个月和两个月(目标2)。此外,它还将探索与抑郁症相关的预测特异性
炎性标志物(与Th1和Th2细胞因子或炎性标志物在其他
精神障碍),并将探索妊娠期间的炎症特征是否与某些
产后抑郁症状(目标3)。通过这种在方法上严格的方法,我们将准备好进行强有力的
产前炎症与产后抑郁症状的方向性相关性检验
确定可能作为风险生物标志物的炎症参数。在这样做的过程中,来自该项目的见解将
对于推进未来的假设至关重要,以阐明解释以下问题的精确神经生物学级联
炎症和产后抑郁症状之间的联系,最终目的是确定新的因素
以预防或治疗产后抑郁症为目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Elysia Poggi Davis其他文献
#80 - - Adverse Childhood Experiences and Pregnant Individuals’ Health in the Perinatal Period
#80 - - 不良童年经历与围产期孕妇健康
- DOI:
10.1016/j.psyneuen.2023.106864 - 发表时间:
2024-02-01 - 期刊:
- 影响因子:3.600
- 作者:
LillyBelle Deer;Chen Su;Jenalee R. Doom;M. Camille Hoffman;Benjamin L. Hankin;Elysia Poggi Davis - 通讯作者:
Elysia Poggi Davis
Does Prenatal Maternal Distress Contribute to Sex Differences in Child Psychopathology?
- DOI:
10.1007/s11920-019-0992-5 - 发表时间:
2019-02-01 - 期刊:
- 影响因子:6.700
- 作者:
Laurel M. Hicks;Danielle A. Swales;Sarah E. Garcia;Camille Driver;Elysia Poggi Davis - 通讯作者:
Elysia Poggi Davis
Placental CRH Trajectories During Gestation and Infant Outcomes
妊娠期间胎盘促肾上腺皮质激素释放激素轨迹与婴儿结局
- DOI:
10.1016/j.psyneuen.2023.106697 - 发表时间:
2024-02-01 - 期刊:
- 影响因子:3.600
- 作者:
Özlü Aran;LillyBelle K. Deer;Melissa Nevarez-Brewster;M. Camille Hoffman;Benjamin L. Hankin;Elysia Poggi Davis - 通讯作者:
Elysia Poggi Davis
Experiences of discrimination during pregnancy predict altered neonatal hair cortisol at birth
孕期遭受歧视的经历预示着新生儿出生时头发皮质醇发生改变。
- DOI:
10.1016/j.psyneuen.2025.107482 - 发表时间:
2025-08-01 - 期刊:
- 影响因子:3.600
- 作者:
Kimberly D’Anna-Hernandez;LillyBelle K. Deer;Özlü Aran;Kenia M. Rivera;Melissa Nevarez-Brewster;Jenalee R. Doom;Benjamin L. Hankin;M. Camille Hoffman;Elysia Poggi Davis - 通讯作者:
Elysia Poggi Davis
Testing the Benefits of Reducing Prenatal Maternal Depression for Maternal and Infant outcomes: A randomized controlled trial
测试降低产前产妇抑郁对母婴结局的益处:一项随机对照试验
- DOI:
10.1016/j.psyneuen.2023.106126 - 发表时间:
2023-07-01 - 期刊:
- 影响因子:3.600
- 作者:
Elysia Poggi Davis;Catherine H. Demers;Ella P. Hennessey;Robert J. Gallop;Nancy K. Grote;Sarah ED Perzow;Mary Curran;M. Camille Hoffman;Benjamin L. Hankin - 通讯作者:
Benjamin L. Hankin
Elysia Poggi Davis的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Elysia Poggi Davis', 18)}}的其他基金
Group-based Prevention of Postpartum Depression: In-person vs. Virtual Delivery
基于团体的产后抑郁症预防:现场分娩与虚拟分娩
- 批准号:
10674881 - 财政年份:2022
- 资助金额:
$ 24.14万 - 项目类别:
Group-based Prevention of Postpartum Depression: In-person vs. Virtual Delivery
基于团体的产后抑郁症预防:现场分娩与虚拟分娩
- 批准号:
10523797 - 财政年份:2022
- 资助金额:
$ 24.14万 - 项目类别:
Reducing maternal prenatal depression to improve child cardiovascular health
减少母亲产前抑郁症,改善儿童心血管健康
- 批准号:
10754441 - 财政年份:2021
- 资助金额:
$ 24.14万 - 项目类别:
Reducing maternal prenatal depression to improve child cardiovascular health
减少母亲产前抑郁症,改善儿童心血管健康
- 批准号:
10326353 - 财政年份:2021
- 资助金额:
$ 24.14万 - 项目类别:
Inflammatory trajectories across pregnancy: Investigating novel markers of risk for postpartum depression
整个怀孕期间的炎症轨迹:研究产后抑郁症风险的新标志物
- 批准号:
10408046 - 财政年份:2021
- 资助金额:
$ 24.14万 - 项目类别:
Reducing maternal prenatal depression to improve child cardiovascular health
减少母亲产前抑郁症,改善儿童心血管健康
- 批准号:
10851438 - 财政年份:2021
- 资助金额:
$ 24.14万 - 项目类别:
Reducing maternal prenatal depression to improve child cardiovascular health
减少母亲产前抑郁症,改善儿童心血管健康
- 批准号:
10543229 - 财政年份:2021
- 资助金额:
$ 24.14万 - 项目类别:
Reducing maternal prenatal depression to improve child cardiovascular health
减少母亲产前抑郁症,改善儿童心血管健康
- 批准号:
10406803 - 财政年份:2021
- 资助金额:
$ 24.14万 - 项目类别:
Reducing maternal prenatal depression to improve child cardiovascular health
减少母亲产前抑郁症,改善儿童心血管健康
- 批准号:
10548740 - 财政年份:2021
- 资助金额:
$ 24.14万 - 项目类别:
Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk Mechanisms
减少胎儿接触母亲抑郁症的机会,改善婴儿风险机制
- 批准号:
9914375 - 财政年份:2017
- 资助金额:
$ 24.14万 - 项目类别:
相似海外基金
Unraveling Adverse Effects of Checkpoint Inhibitors Using iPSC-derived Cardiac Organoids
使用 iPSC 衍生的心脏类器官揭示检查点抑制剂的副作用
- 批准号:
10591918 - 财政年份:2023
- 资助金额:
$ 24.14万 - 项目类别:
Optimization of mRNA-LNP vaccine for attenuating adverse effects and analysis of mechanism behind adverse effects
mRNA-LNP疫苗减轻不良反应的优化及不良反应机制分析
- 批准号:
23K15383 - 财政年份:2023
- 资助金额:
$ 24.14万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of adverse effects of combined exposure to low-dose chemicals in the living environment on allergic diseases and attempts to reduce allergy
阐明生活环境中低剂量化学品联合暴露对过敏性疾病的不良影响并尝试减少过敏
- 批准号:
23H03556 - 财政年份:2023
- 资助金额:
$ 24.14万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Green tea-based nano-enhancer as an adjuvant for amplified efficacy and reduced adverse effects in anti-angiogenic drug treatments
基于绿茶的纳米增强剂作为抗血管生成药物治疗中增强疗效并减少不良反应的佐剂
- 批准号:
23K17212 - 财政年份:2023
- 资助金额:
$ 24.14万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Effects of Tobacco Heating System on the male reproductive function and towards to the reduce of the adverse effects.
烟草加热系统对男性生殖功能的影响以及减少不利影响。
- 批准号:
22H03519 - 财政年份:2022
- 资助金额:
$ 24.14万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mitigating the Adverse Effects of Ultrafines in Pressure Filtration of Oil Sands Tailings
减轻油砂尾矿压力过滤中超细粉的不利影响
- 批准号:
563657-2021 - 财政年份:2022
- 资助金额:
$ 24.14万 - 项目类别:
Alliance Grants
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
1/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10521849 - 财政年份:2022
- 资助金额:
$ 24.14万 - 项目类别:
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
4/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10671022 - 财政年份:2022
- 资助金额:
$ 24.14万 - 项目类别:
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
2/4 ECT 结果和不良反应的破译机制(DECODE)
- 批准号:
10670918 - 财政年份:2022
- 资助金额:
$ 24.14万 - 项目类别:
Adverse Effects of Using Laser Diagnostics in High-Speed Compressible Flows
在高速可压缩流中使用激光诊断的不利影响
- 批准号:
RGPIN-2018-04753 - 财政年份:2022
- 资助金额:
$ 24.14万 - 项目类别:
Discovery Grants Program - Individual