Reducing maternal prenatal depression to improve child cardiovascular health

减少母亲产前抑郁症，改善儿童心血管健康

• 批准号: 10406803
• 负责人: Elysia Poggi Davis
• 金额: $ 2.37万
• 依托单位: UNIVERSITY OF DENVER (COLORADO SEMINARY)
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10406803
• 关键词: Address; Adult; Age; Blood Pressure; Body fat; Body mass index; Cardiovascular Diseases; Cause of Death; Child; Child Behavior; Childhood; Clinical Trials; Development; Diet; Eating Behavior; Exposure to; Feeding behaviors; Feeds; Goals; Health; Health behavior; Intervention; Knowledge; Life; Longevity; Maternal Behavior; Modeling; Mothers; Organizational Policy; Outcome; Physical activity; Physiology; Pregnant Women; Prevention; Randomized Controlled Trials; Research; Risk; Risk Factors; Sampling; Sleep; Testing; Time; Work; antepartum depression; arterial stiffness; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; depressive symptoms; early childhood; efficacious intervention; follow-up; food quality; improved; longitudinal design; maternal depression; next generation; offspring; postnatal; prenatal; prenatal intervention; protective factors; psychosocial; reduce symptoms; symptomatic improvement; trial design; waist circumference

PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors across the lifespan. Research using longitudinal designs, multiple levels of analysis, and experimental clinical trials are needed. Cardiovascular disease (CVD) is the leading cause of death worldwide. The origins of adult CVD begin prenatally: High prenatal maternal depressive symptoms robustly predict offspring CVD risk. However, knowledge on risk and protective factors for CVD for offspring of mothers with high depressive symptoms has been correlational. There is a lack of experimental work using a randomized controlled trial (RCT) design to understand potential mechanisms that contribute to children’s CVD risk following exposure to high maternal prenatal depressive symptoms across multiple levels (e.g., maternal and child behaviors, physiology) over time. Although efficacious interventions to diminish depressive symptoms among pregnant women exist, research has not investigated whether reducing prenatal maternal depressive symptoms can reduce offspring cardiovascular risk. The current study proposes to leverage a RCT of an effective psychosocial intervention for prenatal maternal depression to test whether reducing prenatal maternal depressive symptoms improves offspring cardiovascular health at ages 3-4 years. We hypothesize that the prenatal intervention operates by reducing both prenatal and postnatal depressive symptoms to improve child outcomes. This study will identify intervention targets for offspring of mothers with high prenatal depressive symptoms to reduce cardiovascular risk. These goals will be accomplished by building on a RCT (R01MH109662) of an established psychosocial intervention that effectively reduces maternal prenatal depressive symptoms. We propose to leverage this unique opportunity to follow up mothers and children who participated in this RCT to test whether this intervention improves offspring cardiovascular health. This project increases rigor of the existing correlational research by using an experimental RCT design. The following 3 aims will be addressed. Aim 1: To test whether reducing prenatal maternal depressive symptoms improves the quality of food the mother feeds her child, maternal feeding behaviors, and modeling of eating behaviors at 3 years. Aim 2: To test whether reducing prenatal maternal depressive symptoms improves child diet, eating behaviors, sleep, and physical activity at 3 years. Aim 3: To test whether reducing prenatal maternal depressive symptoms reduces child CVD risk at 3 and 4 years, including BMI, waist circumference, body fat, blood pressure, and arterial stiffness. This project will provide the strongest evidence to date for a mechanistic model of prenatal maternal depressive symptoms’ influence on child cardiovascular health. Importantly, the project will also provide evidence for whether effective psychosocial interventions to reduce prenatal maternal depressive symptoms should be used to reduce the burden of CVD in the next generation.

项目总结/文摘