Impacting the oral HPV continuum: prevention, screening, and early detection

人类乳头瘤病毒(HPV)是导致美国大多数口咽癌的原因 但我们还没有任何有效的筛查方法来检测这些癌症。这 知识差距的部分原因是难以识别口咽部前驱病变。 然而，最近出现了几个有希望的唾液和血液生物标记物，它们可能是 持续口腔HPV16感染的良好标志物，推测为HPV相关的前驱 口咽癌。鉴于人乳头瘤病毒相关口咽癌的发病率上升，我 建议研究口腔HPV连续体，以回答以下4个问题：1)谁处于高潮- HPV-OPC的风险，并将从筛查中受益，2)什么是生物学和行为学 促进口腔HPV持续存在的因素和我们如何减少它们的影响，3)如何优化 筛查口腔持续HPV16感染和HPV-OPC，以及4)如何跟踪和治疗人 世卫组织筛查这些生物标志物阳性以防止HPV相关疾病的发展 口咽癌。

Human papillomavirus (HPV) causes the majority of oropharyngeal cancers in the United States, but we do not yet have any effective screening methods to detect these cancers. This knowledge gap is in part due to difficulties identifying oropharyngeal precursor lesions. However, several promising salivary and blood biomarkers have recently emerged that may be good markers of persistent oral HPV16 infection, the presumed pre-cursor to HPV-related oropharyngeal cancer. Given the increasing incidence of HPV-related oropharyngeal cancer, I propose to study the oral HPV continuum to answer the following 4 questions: 1) who is at high- risk for HPV-OPC and would benefit from screening, 2) What are the biologic and behavioral factors promoting oral HPV persistence and how can we reduce their effects, 3) how to optimally screen for persistent oral HPV16 infection and HPV-OPC, and 4) How to follow and treat people who screen positive for these biomarkers to prevent the development of HPV-related oropharyngeal cancer.