Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosis

MACS/WIHS联合队列研究（MWCCS）管理补充： 抽象的。虽然最近在艾滋病毒感染者（PWH）的临床护理方面发生了重大变化（例如， 普遍的ART启动，更多地使用他汀类药物作为预防）减少了心血管疾病 疾病（CVD）风险，可能增加CVD风险的并发症（例如，转向 整合酶抑制剂作为一线HIV治疗，HIV人群的持续老龄化）意味着， 威尔斯亲王医院心血管疾病的决定因素不断变化。我们有机会扩大我们的 妇女、社区和儿童服务部现有的关于妇女与艾滋病毒相关的心血管疾病的组学措施数据库， 男性，并通过对微生物组、代谢组和 性激素我们建议使用存档的标本来测量肠道微生物群，并选择 微生物组相关代谢物和免疫标志物组，包括免疫标志物 激活、肠屏障功能障碍和微生物移位与颈动脉 动脉粥样硬化在MWCCS男性，并评估独立和中介作用的性别 荷尔蒙在这种关系中的作用。我们的目标支持 福尔斯属于以下NIH高优先级艾滋病指定主题的艾滋病毒/艾滋病研究：1） 免疫功能障碍，持续性炎症，以及微生物组和遗传决定因素， 支持高度优先的艾滋病毒合并症的发展，和2）长期治疗或 在整个生命周期中针对艾滋病毒相关共病状况的预防策略。

MACS/WIHS Combined Cohort Study (MWCCS) Administrative Supplement: Abstract. While significant recent changes in the clinical care of people with HIV (PWH) (e.g., universal ART initiation, greater use of statins as prophylaxis) have reduced cardiovascular disease (CVD) risk, concurrent developments that may increase CVD risk (e.g., shift to integrase inhibitors as first-line HIV treatment, continued aging of the HIV population) mean that the determinants of CVD in PWH are ever-changing. We have the opportunity to extend our existing MWCCS database of -omics measures in women in relation to HIV-associated CVD to men, and expand the scope with additional assessments of the microbiome, metabolome, and sex hormones. We propose to use archived specimens to measure gut microbiota and selected microbiome-related metabolites and immune marker panels, including markers of immune activation, gut barrier dysfunction and microbial translocation in relation to carotid atherosclerosis in MWCCS men, and assess both the independent and mediating roles of sex hormones in this relationship among both women and men with HIV. Our aims support HIV/AIDS research that falls under the following NIH high priority AIDS-designated topics: 1) immune dysfunction, persistent inflammation, and microbiome and genetic determinants that underpin the development of high priority HIV co-morbidities, and 2) long-term treatment or prevention strategies for HIV-relevant comorbid conditions across the lifespan.