Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosis

MACS/WIHS联合队列研究(MWCCS)行政补编： 抽象的。虽然最近艾滋病毒(PWH)患者的临床护理发生了重大变化(例如， 普遍开展抗逆转录病毒治疗，更多地使用他汀类药物作为预防措施)减少了心血管疾病 疾病(CVD)风险，可能增加CVD风险的并发发展(例如，转变为 整合酶抑制剂作为艾滋病毒的一线治疗，艾滋病毒人口的持续老龄化)意味着 PWH中心血管疾病的决定因素是不断变化的。我们有机会延长我们的 现有MWCCS数据库-妇女与艾滋病毒相关心血管疾病相关的组学措施 扩大范围，对微生物组、代谢组和 性激素。我们建议使用存档的标本来测量肠道微生物区系，并选择 微生物组相关代谢物和免疫标记物，包括免疫标记物 激活、肠道屏障功能障碍和微生物易位与颈动脉的关系 MWCCS男性的动脉粥样硬化，并评估性的独立和中介作用 女性和男性艾滋病毒携带者之间的这种关系中的激素。我们的AIMS支持 艾滋病毒/艾滋病研究，属于以下NIH指定的高度优先艾滋病主题：1) 免疫功能障碍，持续性炎症，微生物组和遗传决定因素 支持发展高度优先的艾滋病毒共病，以及2)长期治疗或 针对艾滋病毒相关终生共病的预防战略。

MACS/WIHS Combined Cohort Study (MWCCS) Administrative Supplement: Abstract. While significant recent changes in the clinical care of people with HIV (PWH) (e.g., universal ART initiation, greater use of statins as prophylaxis) have reduced cardiovascular disease (CVD) risk, concurrent developments that may increase CVD risk (e.g., shift to integrase inhibitors as first-line HIV treatment, continued aging of the HIV population) mean that the determinants of CVD in PWH are ever-changing. We have the opportunity to extend our existing MWCCS database of -omics measures in women in relation to HIV-associated CVD to men, and expand the scope with additional assessments of the microbiome, metabolome, and sex hormones. We propose to use archived specimens to measure gut microbiota and selected microbiome-related metabolites and immune marker panels, including markers of immune activation, gut barrier dysfunction and microbial translocation in relation to carotid atherosclerosis in MWCCS men, and assess both the independent and mediating roles of sex hormones in this relationship among both women and men with HIV. Our aims support HIV/AIDS research that falls under the following NIH high priority AIDS-designated topics: 1) immune dysfunction, persistent inflammation, and microbiome and genetic determinants that underpin the development of high priority HIV co-morbidities, and 2) long-term treatment or prevention strategies for HIV-relevant comorbid conditions across the lifespan.