2022 CCS Oral Microbiome and Pulmonary Function Supplement

2022 CCS 口腔微生物组和肺功能补充剂

• 批准号: 10659696
• 负责人: Gypsyamber D'Souza
• 金额: $ 1.54万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-09 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659696
• 关键词: Acquired Immunodeficiency Syndrome; Address; Alcohol consumption; Antibiotics; Bacteria; Biological Assay; Blood specimen; Cardiovascular Diseases; Cell Separation; Chronic Obstructive Pulmonary Disease; Clinical; Data; Dental; Dental Care; Dental Hygiene; Dental caries; Diet; Disease; Environment; Evaluation; Funding; Gingivitis; HIV; HIV Seronegativity; Health; Hypertension; Immune response; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunologic Deficiency Syndromes; Immunologic Markers; Individual; Inflammation; Inflammatory Response Pathway; Influentials; Intervention; Investigation; Knowledge; Lead; Link; Lung; Lung diseases; Magnetism; Measurement; Measures; Medicine; Microbe; North Carolina; Oral; Oral cavity; Oral health; Outcome; Participant; Pathogenesis; Periodontitis; Peripheral; Persons; Play; Population; Predisposition; Property; Pulmonary Emphysema; Pulmonary Inflammation; Pulmonary function tests; Quality of life; Questionnaires; Research Personnel; Respiratory Signs and Symptoms; Risk Factors; Role; Saliva; Sampling; Science; Site; Smoking; Stroke; Systemic disease; Taxonomy; Techniques; Testing; Time; Toothbrushing; Training; United States National Institutes of Health; Universities; Visit; airway obstruction; antiretroviral therapy; bacterial community; comorbidity; cytokine; data centers; dysbiosis; functional disability; fungus; improved; insight; interdisciplinary collaboration; lung health; microbial; microbial community; microbial host; microbiome; microbiome analysis; microbiome composition; modifiable risk; mortality; next generation; novel; oral HIV; oral lesion; oral microbiome; pulmonary function; response; saliva sample; social health determinants; sociodemographic factors; soft tissue; systemic inflammatory response; therapy development; vaping

Abstract. FY 2022 OAR Strategic Funds are requested to perform a detailed investigation of the relationship of the oral microbiome, immune response, and HIV to chronic obstructive pulmonary disease (COPD). COPD, including airway obstruction and emphysema, is an increasing health problem in people with HIV (PWH) even in the current era of antiretroviral therapy (ART). Our preliminary data suggest that the oral microbiome is associated with lung function, but we lack a detailed understanding of the role of particular microbial communities and the potential mechanisms underpinning the association, which currently impedes development of intervention strategies. We will utilize oral data, microbiome analyses, blood specimens, and pulmonary function measures already being collected throughout MWCCS in visits 102 and 103 in order to analyze the relationship of oral health and the oral microbiome to lung function. We will also perform measurements of peripheral cytokines, inflammatory responses, and the oral cavity environment to assess potential mechanisms linking the microbiome to lung health. These investigations will be performed in all individuals who have completed pulmonary function testing across MWCCS. We will then perform detailed oral evaluations and collect microbial samples from multiple oral niches in a subset of participants to better delineate relationships of specific oral health components and lung function at Pitt and UNC. Using a novel technique to identify immunoglobulin-bound bacteria and fungi, we will identify key microbes that drive host response and are related to COPD. These investigations will identify potentially modifiable targets contributing to COPD in PWH. We will address NIH high priority AIDS-designated topics of: 1) a common and high-burden HIV- associated comorbidity; 2) interdisciplinary collaborations among experts in pulmonary disease, microbiome, dental medicine, and analytics; 3) disparities in HIV given impact of social determinants of health on both lung function and oral health; 4) fundamental discovery in cross- cutting science; and 5) training the next generation of HIV investigators.

抽象。2022财年OAR战略基金被要求进行详细调查， 口腔微生物组、免疫反应和HIV与慢性阻塞性肺病的关系 肺疾病（COPD）。COPD，包括气道阻塞和肺气肿，是一种 艾滋病毒感染者（PWH）的健康问题日益严重，即使在当前的抗逆转录病毒时代 治疗（ART）。我们的初步数据表明，口腔微生物组与肺 功能，但我们缺乏对特定微生物群落的作用的详细了解 以及支撑这种联系的潜在机制，这种机制目前阻碍了 制定干预战略。我们将利用口腔数据微生物组分析血液 标本和肺功能测量已经在整个MWCCS中收集， 访问102和103，以分析口腔健康和口腔微生物组的关系， 肺功能我们还将测量外周细胞因子、炎症因子、 反应，和口腔环境，以评估潜在的机制， 微生物对肺部健康的影响这些调查将在所有有以下情况的个人中进行 在MWCCS中完成肺功能测试。然后我们将进行详细的口头 评估并收集参与者子集中多个口腔龛的微生物样本， 更好地描述特定口腔健康成分与皮特肺功能的关系， - 是的使用一种新的技术来识别免疫球蛋白结合的细菌和真菌，我们将 确定驱动宿主反应并与COPD相关的关键微生物。这些调查 将确定潜在的可修改的目标，有助于慢性阻塞性肺疾病在威尔斯亲王医院。 我们将讨论NIH高优先级艾滋病指定的主题：1）一个共同的和高负担的艾滋病毒- 2）肺部疾病专家之间的跨学科合作， 微生物组，牙科医学和分析; 3）艾滋病毒对社会影响的差异 肺功能和口腔健康的健康决定因素; 4）交叉研究的基本发现， 切割科学;和5）培训下一代艾滋病毒调查人员。