2022 CCS Oral Microbiome and Pulmonary Function Supplement
2022 CCS Oral Microbiome and Pulmonary Function Supplement
批准号:
10659696
负责人:
Gypsyamber D'Souza
金额:
$1.54万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
未结题
起止时间:
2019-04-09 至 2026-03-31
关键词:
Acquired Immunodeficiency SyndromeAddressAlcohol consumptionAntibioticsBacteriaBiological AssayBlood specimenCardiovascular DiseasesCell SeparationChronic Obstructive Pulmonary DiseaseClinicalDataDentalDental CareDental HygieneDental cariesDietDiseaseEnvironmentEvaluationFundingGingivitisHIVHIV SeronegativityHealthHypertensionImmune responseImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunoglobulinsImmunologic Deficiency SyndromesImmunologic MarkersIndividualInflammationInflammatory Response PathwayInfluentialsInterventionInvestigationKnowledgeLeadLinkLungLung diseasesMagnetismMeasurementMeasuresMedicineMicrobeNorth CarolinaOralOral cavityOral healthOutcomeParticipantPathogenesisPeriodontitisPeripheralPersonsPlayPopulationPredispositionPropertyPulmonary EmphysemaPulmonary InflammationPulmonary function testsQuality of lifeQuestionnairesResearch PersonnelRespiratory Signs and SymptomsRisk FactorsRoleSalivaSamplingScienceSiteSmokingStrokeSystemic diseaseTaxonomyTechniquesTestingTimeToothbrushingTrainingUnited States National Institutes of HealthUniversitiesVisitairway obstructionantiretroviral therapybacterial communitycomorbiditycytokinedata centersdysbiosisfunctional disabilityfungusimprovedinsightinterdisciplinary collaborationlung healthmicrobialmicrobial communitymicrobial hostmicrobiomemicrobiome analysismicrobiome compositionmodifiable riskmortalitynext generationnoveloral HIVoral lesionoral microbiomepulmonary functionresponsesaliva samplesocial health determinantssociodemographic factorssoft tissuesystemic inflammatory responsetherapy developmentvaping
中文摘要
摘要。2022财年桨叶战略基金被要求进行详细的调查
英文摘要
Abstract. FY 2022 OAR Strategic Funds are requested to perform a detailed investigation of
the relationship of the oral microbiome, immune response, and HIV to chronic obstructive
pulmonary disease (COPD). COPD, including airway obstruction and emphysema, is an
increasing health problem in people with HIV (PWH) even in the current era of antiretroviral
therapy (ART). Our preliminary data suggest that the oral microbiome is associated with lung
function, but we lack a detailed understanding of the role of particular microbial communities
and the potential mechanisms underpinning the association, which currently impedes
development of intervention strategies. We will utilize oral data, microbiome analyses, blood
specimens, and pulmonary function measures already being collected throughout MWCCS in
visits 102 and 103 in order to analyze the relationship of oral health and the oral microbiome to
lung function. We will also perform measurements of peripheral cytokines, inflammatory
responses, and the oral cavity environment to assess potential mechanisms linking the
microbiome to lung health. These investigations will be performed in all individuals who have
completed pulmonary function testing across MWCCS. We will then perform detailed oral
evaluations and collect microbial samples from multiple oral niches in a subset of participants to
better delineate relationships of specific oral health components and lung function at Pitt and
UNC. Using a novel technique to identify immunoglobulin-bound bacteria and fungi, we will
identify key microbes that drive host response and are related to COPD. These investigations
will identify potentially modifiable targets contributing to COPD in PWH.
We will address NIH high priority AIDS-designated topics of: 1) a common and high-burden HIV-
associated comorbidity; 2) interdisciplinary collaborations among experts in pulmonary disease,
microbiome, dental medicine, and analytics; 3) disparities in HIV given impact of social
determinants of health on both lung function and oral health; 4) fundamental discovery in cross-
cutting science; and 5) training the next generation of HIV investigators.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study
-
批准号:10376145
-
项目类别:
-
资助金额:$453.41万
-
财政年份:2019
-
负责人:Gypsyamber D'Souza
-
依托单位:
Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study
-
批准号:10221841
-
项目类别:
-
资助金额:$13.05万
-
财政年份:2019
-
负责人:Gypsyamber D'Souza
-
依托单位:
Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study
-
批准号:10612772
-
项目类别:
-
资助金额:$445.93万
-
财政年份:2019
-
负责人:Gypsyamber D'Souza
-
依托单位:
Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study
-
批准号:10221823
-
项目类别:
-
资助金额:$4.15万
-
财政年份:2019
-
负责人:Gypsyamber D'Souza
-
依托单位:
Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study
-
批准号:9912210
-
项目类别:
-
资助金额:$453.07万
-
财政年份:2019
-
负责人:Gypsyamber D'Souza
-
依托单位:
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosis
-
批准号:10656874
-
项目类别:
-
资助金额:$1.17万
-
财政年份:2019
-
负责人:Gypsyamber D'Souza
-
依托单位:
Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study
-
批准号:10392680
-
项目类别:
-
资助金额:$1.63万
-
财政年份:2019
-
负责人:Gypsyamber D'Souza
-
依托单位:
Impacting the oral HPV continuum: prevention, screening, and early detection
-
批准号:10658898
-
项目类别:
-
资助金额:$104.79万
-
财政年份:2016
-
负责人:Gypsyamber D'Souza
-
依托单位:
Impacting the oral HPV continuum: prevention, screening, and early detection
-
批准号:10220942
-
项目类别:
-
资助金额:$105.77万
-
财政年份:2016
-
负责人:Gypsyamber D'Souza
-
依托单位:
Impacting the oral HPV continuum: prevention, screening, and early detection
-
批准号:10447118
-
项目类别:
-
资助金额:$104.71万
-
财政年份:2016
-
负责人:Gypsyamber D'Souza
-
依托单位:
Impacting the oral HPV continuum: prevention, screening, and early detection
-
批准号:9976996
-
项目类别:
-
资助金额:$105.77万
-
财政年份:2016
-
负责人:Gypsyamber D'Souza
-
依托单位:
Effect of HIV and immunosuppression on oral HPV persistence in the HAART era
-
批准号:8250398
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项目类别:
-
资助金额:$73.45万
-
财政年份:2010
-
负责人:Gypsyamber D'Souza
-
依托单位:
Effect of HIV and immunosuppression on oral HPV persistence in the HAART era
-
批准号:8527962
-
项目类别:
-
资助金额:$33.18万
-
财政年份:2010
-
负责人:Gypsyamber D'Souza
-
依托单位:
Effect of HIV and immunosuppression on oral HPV persistence in the HAART era
-
批准号:8665810
-
项目类别:
-
资助金额:$83.91万
-
财政年份:2010
-
负责人:Gypsyamber D'Souza
-
依托单位:
Effect of HIV and immunosuppression on oral HPV persistence in the HAART era
-
批准号:8131021
-
项目类别:
-
资助金额:$75.35万
-
财政年份:2010
-
负责人:Gypsyamber D'Souza
-
依托单位:
Effect of HIV and immunosuppression on oral HPV persistence in the HAART era
-
批准号:8456172
-
项目类别:
-
资助金额:$95.54万
-
财政年份:2010
-
负责人:Gypsyamber D'Souza
-
依托单位:
Center/Coordination, Analysis and Management/MACS
-
批准号:9032426
-
项目类别:
-
资助金额:$347.32万
-
财政年份:1993
-
负责人:Gypsyamber D'Souza
-
依托单位:
Project 5
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批准号:8395763
-
项目类别:
-
资助金额:$31.87万
-
财政年份:--
-
负责人:Gypsyamber D'Souza
-
依托单位:
Project 5
-
批准号:8529492
-
项目类别:
-
资助金额:$39.58万
-
财政年份:--
-
负责人:Gypsyamber D'Souza
-
依托单位:
Project 5
-
批准号:8703525
-
项目类别:
-
资助金额:$38.3万
-
财政年份:--
-
负责人:Gypsyamber D'Souza
-
依托单位:
海外基金