RC1: Pre-Clinical Research Core
RC1:临床前研究核心
基本信息
- 批准号:10221556
- 负责人:
- 金额:$ 23.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-06-15 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcarboseAddressAffectAgeAgingAmericanAwardBiology of AgingBrainCallithrixCallithrix jacchus jacchusCapsicumCardiacCardiovascular systemClinical ResearchCollagenCountryDepositionDevelopmentDiseaseEducational workshopElastinElderlyEstradiolFRAP1 geneFoundationsFundingGeroscienceGrantHeartHumanInterventionKidneyKnowledgeLife ExtensionLipidsLiverLongevityMagnetic Resonance ImagingMeasurementMetforminMissionModelingMyocardial dysfunctionNational Institute of Dental and Craniofacial ResearchPathologyPharmacologic SubstancePharmacologyPhasePhenotypePlasmaPlayPre-Clinical ModelPrimatesProcessResearchResearch DesignResearch PersonnelResearch SupportResearch TrainingResourcesRodentRoleSamplingScientistServicesShockSignal PathwaySirolimusSourceTechnologyTestingTissue BanksTissue SampleTissuesTrainingTranslatingTranslationsUnited States National Institutes of Healthage effectage relatedagedbasecardiovascular healthcomparativecostexecutive functiongut microbiomehealthspanhealthy agingimmune functionimprovedinnovationinterestlipidomelipidomicsmeetingsmicrobiomenonhuman primatenovelpre-clinicalpre-clinical researchprogramsprospectiveresearch data disseminationskillssocialsuccesssymposiumtranslational model
项目摘要
Several interventions have been shown to promote healthy life extension in rodents. However, analogous
prospective, interventional lifespan studies in healthy people are extremely challenging. The Pre-clinical
Research Core (RC1) of the SA OAIC addresses this barrier by providing the knowledge, skills, and technical
support to assist OAIC investigators in using the common marmoset (Callithrix jacchus) as a pre-clinical model
for translational geroscience research. RC1 focuses on marmosets as a pre-clinical model for several reasons:
a) They are relatively short-lived nonhuman primates; b) marmosets are small (300-500 g), requiring less
costs for husbandry and compound administration; c) marmosets can be maintained in their usual social
configurations; d) their spectrum of naturally-occurring age-related pathologies is comparable to that of humans;
and e) they allow assessment of interventions in tissues that cannot be readily collected in people (e.g. brain,
heart, kidney, liver). Reflecting the interest in this model, the NIA recently released an RFA entitled
“Characterization of Marmosets as Models of Aging and Age-Related Diseases”.
RC1 achieves its mission through the following Specific Aims: 1) Provide OAIC investigators access to a
unique colony of aging marmosets; 2) Provide resources required for studying effects of aging interventions on
marmoset healthspan; 3) Provide and maintain a bank of tissues from marmosets across the age range; 4)
Provide services to assess analytical pharmacology in marmosets; and 5) Support the research training and
dissemination missions of the OAIC.
During the initial award cycle, RC1 successfully assisted 13 OAIC funded projects and an additional 13
external projects. RC1 provided tissues to 16 more scientists. Other key accomplishment of RC1 include:
• Perform the initial characterization of several aging phenotypes of marmosets, including functional changes
with age in executive function, kidney pathology, cardiovascular health, immune function, and the microbiome;
• Conduct the first study testing whether nonhuman primate lifespan is extended by a pharmaceutical
intervention (rapamycin);
• Carry out early-phase pharmacology and tolerability studies with metformin, acarbose and 17α-estradiol that
will lay the foundation for long-term lifespan and healthspan trials;
• Assist OAIC Scholars and pilot grant recipients to successfully obtain funding from several external sources
(NIA, NIDCR, and AFAR) to expand and extend their studies with marmosets; and
• Enhance the visibility of the marmoset model and promote use of this valuable resource across the country.
During the next award cycle, RC1 will support 2 pilot, 1 Scholar and 10 external projects. RC1 also will support
two developmental projects (DPs) with highly innovative features: DP1 entitled “Human-marmoset comparative
assessment of the role of mTOR in cardiac aging”, and DP2 entitled “Comparative lipidomics of aging”.
一些干预措施已被证明可以促进啮齿动物的健康寿命延长。然而,类比
在健康人群中进行的前瞻性、干预性寿命研究极具挑战性。临床前
SA OAIC的研究核心(RC 1)通过提供知识,技能和技术来解决这一障碍。
支持OAIC研究人员使用普通绒猴(Callithrix jacchus)作为临床前模型
用于老年科学的转化研究RC 1专注于将绒猴作为临床前模型,原因如下:
a)它们是相对短寿命的非人类灵长类动物; B)绒猴很小(300-500 g),需要较少的能量。
饲养和复合管理的成本; c)绒猴可以维持在它们通常的社会环境中,
d)它们的自然发生的年龄相关病理学谱与人类的谱相当;
和e)它们允许评估在人体内不能容易收集的组织(例如脑,
心脏、肾脏、肝脏)。为了反映对这种模式的兴趣,NIA最近发布了一份RFA,
“作为衰老和衰老相关疾病模型的绒猴特征”。
RC 1通过以下具体目标实现其使命:1)向OAIC调查员提供访问
衰老绒猴的独特群体; 2)提供研究衰老干预措施对
绒猴健康span; 3)提供并维持来自各年龄段绒猴的组织库; 4)
提供服务以评估绒猴的分析药理学;以及5)支持研究培训和
OAIC的传播任务。
在最初的奖励周期,RC 1成功地协助了13个OAIC资助的项目和另外13个项目。
外部项目。RC 1为另外16名科学家提供了组织。RC 1的其他主要成就包括:
·对绒猴的几种老化表型进行初步表征,包括功能变化
随着年龄的增长,执行功能,肾脏病理,心血管健康,免疫功能和微生物组;
·进行第一项研究,测试非人类灵长类动物的寿命是否可以通过药物延长
干预(雷帕霉素);
·开展二甲双胍、阿卡波糖和17α-雌二醇的早期药理学和耐受性研究,
将为长期寿命和健康寿命试验奠定基础;
·协助OAIC学者和试点赠款获得者成功地从几个外部来源获得资金
(NIA,NIDCR和AFAR),以扩大和扩展他们对绒猴的研究;
·提高绒猴模型的知名度,并在全国范围内推广使用这一宝贵资源。
在下一个奖励周期,RC 1将支持2个试点项目,1个学者和10个外部项目。RC 1还将支持
两个具有高度创新特征的开发项目(DP):DP 1,题为“人类-绒猴比较
评估mTOR在心脏衰老中的作用”,以及题为“衰老的比较脂质组学”的DP 2。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Adam Salmon其他文献
Adam Salmon的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Adam Salmon', 18)}}的其他基金
mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
mTOR 介导的肝胰岛素抵抗中脂肪酸去饱和。
- 批准号:
10339318 - 财政年份:2021
- 资助金额:
$ 23.2万 - 项目类别:
mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
mTOR 介导的肝胰岛素抵抗中脂肪酸去饱和。
- 批准号:
10554280 - 财政年份:2021
- 资助金额:
$ 23.2万 - 项目类别:
mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
mTOR 介导的肝胰岛素抵抗中脂肪酸去饱和。
- 批准号:
10013714 - 财政年份:2021
- 资助金额:
$ 23.2万 - 项目类别:
Primary fibroblast resiliency as a predictor of health and lifespan in mice
原代成纤维细胞弹性作为小鼠健康和寿命的预测因子
- 批准号:
9422077 - 财政年份:2017
- 资助金额:
$ 23.2万 - 项目类别:
The role of mTOR inhibition on longevity and healthy aging in a non-human primate
mTOR 抑制对非人类灵长类动物寿命和健康衰老的作用
- 批准号:
9145150 - 财政年份:2015
- 资助金额:
$ 23.2万 - 项目类别:
The role of mTOR inhibition on longevity and healthy aging in a non-human primate
mTOR 抑制对非人类灵长类动物寿命和健康衰老的作用
- 批准号:
9282387 - 财政年份:2015
- 资助金额:
$ 23.2万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 23.2万 - 项目类别:
Research Grant