Resource Core (RC)

CPOC总结/摘要 临床和人口结局核心（CPOC）提倡采用多学科方法进行评估 OAIC临床研究中的流动性和平衡，通过三个关键功能：（i）让老年人参与， 社区和长期护理机构作为参与者（在一系列大规模登记中）和合作伙伴 （通过我们的社区咨询委员会）在研究中;（ii）为研究人员提供适当的培训 接触，筛选，并同意与老年人口的研究策略;（iii）分享专业知识， 临床评估方法（通过评估工具和研究数据集的标准化库）， 灵活性、平衡和福尔斯。核心的生产力一直很高。在过去的5年里，CPOC提供了 为13个试点或发展项目提供支持，包括为5名区域环境中心受训飞行员提供咨询。我们的支持 捐助了8个新资助的赠款（4个R 01，2个K 01，1个VA，1个基金会），并支持了40多个 独立资助的外部项目。CPOC的支持导致了200多份出版物。CPOC 成功推出白金长期护理登记处（老年人居住在辅助生活和熟练 同意研究联系的护理机构），有40多个机构招募点和400多个 居民登记。CPOC社区登记处包括2500多名老年参与者，并已成为 60项研究的主要招募来源。CPOC SMART中心提供临床研究空间 并作为一个试验台的创新设备和实验范式设计的数量 集成系统核心，我们的新型移动的实验室利用非侵入性，便携式技术， 检查现场的移动性、平衡性和身体活动。在更新中，我们将1）增加招聘， 研究人员使用Pepper长期护理-白金和社区登记，简化网络 2）通过与我们的PCORI的伙伴关系，扩大传播和实施工作， 资助面向患者的“故事亭”计划; 3）通过增加额外的 调查工具，包括活动记录仪和肌肉和脂肪的超声评估;以及4）实施 开发试点，“通过机器学习进行的自动化邻里步行能力审计”，与同事在 我们的工程学院开发基于计算机的自动化方法来审计谷歌街景 与老年人的移动性和福尔斯最相关的环境特征的图像。拟议 发展试验将提供关于外部物理环境的重要信息，这是一个被忽视的领域 福尔斯风险。核心的领导继续与博士史蒂芬M。阿尔伯特和现在包括安德烈罗索博士， 他将共同指导并领导我们的发展项目。

CPOC Summary/Abstract The Clinical and Population Outcomes Core (CPOC) promotes a multidisciplinary approach to the assessment of mobility and balance in OAIC clinical research through three key functions: (i) engaging older adults from the community and long-term care settings as participants (in a series of large-scale registries) and partners (through our Community Advisory Board) in research; (ii) providing training to investigators on appropriate contact, screening, and consent strategies for research with older populations; and (iii) sharing expertise in clinical assessment methodology (though a standardized library of assessment tools and study datasets) for mobility, balance, and falls. The Core has been highly productive. Over the past 5 years CPOC has provided support for 13 pilot or developmental projects, including consultation for 5 REC trainee pilots. Our support has contributed to 8 newly funded grants (4 R01, 2 K01, 1 VA, 1 foundation) and has supported over 40 independently funded external projects. CPOC support has resulted in over 200 publications. CPOC successfully launched the Platinum Long-Term Care Registry (seniors residing in assisted living and skilled nursing facilities who have consented to research contact), with over 40 facility recruitment sites and over 400 residents enrolled. The CPOC Community Registry includes over 2500 older participants and has served as a key recruitment source for 60 research studies. The CPOC SMART Center provides clinical research space and serves as a testbed for a number of innovative devices and experimental paradigms designed by the Integrative Systems Core, and our novel mobile laboratory utilizes noninvasive, portable technology to examine mobility, balance, and physical activity in the field. In the renewal we will 1) increase recruitment and researcher use of the Pepper Long-Term Care-Platinum and Community Registries, with streamlined web access and oversight; 2) expand dissemination-implementation efforts through a partnership with our PCORI- funded patient-oriented “Story Booth” program; 3) expand our mobile laboratory by adding additional investigative tools, including actigraphy and ultrasound assessment of muscle and fat; and 4) implement a developmental pilot, “Automated Neighborhood Walkability Audits by Machine Learning,” with colleagues in our School of Engineering to develop computer-based, automated methods for auditing Google Street View images for environmental features most relevant to mobility and falls in older adults. The proposed developmental pilot will provide important information on external physical environments, a neglected domain for falls risk. Leadership of the Core continues with Dr. Steven M. Albert and now includes Dr. Andrea Rosso, who will co-direct and also lead our developmental project.