Cooperative Research Center for NanoScaffold-Based Chlamydia trachomatis Vaccines - Admin Core

项目概要/摘要 沙眼衣原体（Ct）是最常见的细菌性性传播感染（STI）， 每年影响超过1.3亿人，是最常见的可预防疾病 全世界失明在美国，由C.沙眼占全球 美元的年度成本。因为感染可能没有症状，它可能多年不治疗 并可能导致长期后遗症，包括盆腔炎、慢性腹部疾病、 疼痛、宫外孕和不孕症。Ct是一种广泛存在于细胞内的细菌病原体 在全世界都有。为了满足对C.沙眼疫苗 行政核心将负责管理、协调、监督 进展，并监督整个中心的活动范围，包括发展 研究计划（DRP）。这将涉及三个主要地点之间的工作协调： LLNL，UCI和UCD重点发展年轻科学家和新技术， 减轻与C相关的健康影响。沙眼核心将侧重于以下四个方面 1）提供协调，以促进CRC项目PI和核心 董事们。2)确保内部数据共享和一个用于科学推广的外部网站。第三章 建立和管理发展研究计划。4)评估中心的 利用内部和外部咨询审查取得进展。

PROJECT SUMMARY/ABSTRACT Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection (STI), affecting over 130 million people every year, and is the most common cause of preventable blindness worldwide. In the United States, STIs caused by C. trachomatis account for billions of dollars in annual costs. Because the infection can be asymptomatic, it may go untreated for years and can result in long-term sequelae, including pelvic inflammatory disease, chronic abdominal pain, ectopic pregnancy, and infertility. Ct is an intracellular bacterial pathogen widespread throughout the world. In order to address the critical need for a C. trachomatis vaccine, the Administrative Core will be responsible for managing, coordinating, monitoring overall progress, and supervising the entire range of the center's activities, including the Developmental Research Program (DRP). This will involve coordination of work between three primary sites: LLNL, UCI and UCD with an emphasis on developing young scientist and novel technologies to mitigate health effects associated with C. trachomatis. The Core will focus on the following four areas: 1) Provide coordination to facilitate interactions among the CRC Project PIs and Core Directors. 2) To ensure internal data sharing and an external site for scientific outreach. 3) Establish and administrate the Developmental Research Program. 4) Evaluate the Center's progress utilizing internal and external advisory reviews.