Cooperative Research Center for NanoScaffold-Based Chlamydia trachomatis Vaccines - Admin Core

项目摘要/摘要 沙眼衣原体(Ct)是最常见的细菌性性传播感染(STI)， 每年影响超过1.3亿人，是最常见的可预防的原因 世界范围内的失明。在美国，由沙眼衣原体引起的性传播感染占数十亿 美元的年度成本。由于感染可能是无症状的，它可能会在几年内得不到治疗 并会导致长期的后遗症，包括盆腔炎、慢性腹部 疼痛、宫外孕和不孕不育。CT是一种广泛存在于细胞内的细菌病原体 在世界各地。为了解决沙眼衣原体疫苗的迫切需求， 行政核心将负责管理、协调、监测总体情况 进展，并监督中心的整个活动范围，包括发展 研究计划(DRP)。这将涉及协调三个主要地点之间的工作： LLNL、UCI和UCD，重点培养青年科学家和新技术，以 减轻与沙眼衣原体相关的健康影响。核心将重点放在以下四个方面 领域：1)提供协调，以促进儿童权利中心项目绩效指标和核心项目之间的互动 董事们。2)确保内部数据共享和科学外展的外部站点。3) 建立和管理发展研究计划。4)评估中心的 利用内部和外部咨询审查取得进展。

PROJECT SUMMARY/ABSTRACT Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection (STI), affecting over 130 million people every year, and is the most common cause of preventable blindness worldwide. In the United States, STIs caused by C. trachomatis account for billions of dollars in annual costs. Because the infection can be asymptomatic, it may go untreated for years and can result in long-term sequelae, including pelvic inflammatory disease, chronic abdominal pain, ectopic pregnancy, and infertility. Ct is an intracellular bacterial pathogen widespread throughout the world. In order to address the critical need for a C. trachomatis vaccine, the Administrative Core will be responsible for managing, coordinating, monitoring overall progress, and supervising the entire range of the center's activities, including the Developmental Research Program (DRP). This will involve coordination of work between three primary sites: LLNL, UCI and UCD with an emphasis on developing young scientist and novel technologies to mitigate health effects associated with C. trachomatis. The Core will focus on the following four areas: 1) Provide coordination to facilitate interactions among the CRC Project PIs and Core Directors. 2) To ensure internal data sharing and an external site for scientific outreach. 3) Establish and administrate the Developmental Research Program. 4) Evaluate the Center's progress utilizing internal and external advisory reviews.