Preclinical Medications Screening in Dependence, Affect and Pain Models of Alcoholism

酒精中毒依赖性、情感和疼痛模型的临床前药物筛选

• 批准号: 10227892
• 负责人: SCOTT EDWARDS, PHD
• 金额: $ 21.02万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-27 至 2021-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227892
• 关键词: Affect; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Blood; Consumption; Contracts; Data; Data Analyses; Data Collection; Data Display; Dependence; Development; Drug Kinetics; Female; Heavy Drinking; Human Resources; Industry; Liquid substance; Measures; Modeling; Motor Activity; National Institute on Alcohol Abuse and Alcoholism; Pain; Pharmaceutical Preparations; Rattus; Reporting; Specificity; Standardization; Sucrose; Testing; blind; design; hypnotic; interest; male; negative affect; pain model; pain sensitivity; pre-clinical; screening

The scope of this contract is to perform the blind testing of reference compounds, compounds of interest, and proprietary compounds from industry suppliers, on alcohol drinking in rats using models of various aspects of alcohol dependence including excessive drinking, negative affect and pain. The requirement involves compound storage and administration, data collection and recording, data analysis, and reporting subsequent to said testing.

本合同的范围是对来自行业供应商的参比化合物、感兴趣的化合物和专有化合物进行盲法测试，使用酒精依赖的各个方面的模型（包括过度饮酒、负面影响和疼痛）对大鼠进行饮酒。该要求涉及化合物储存和管理、数据收集和记录、数据分析以及所述测试后的报告。