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TRAPping loss of control in binge eating

TRAPping loss of control in binge eating
导致暴饮暴食失控
批准号:
10397637
负责人:
ERIC P ZORRILLA
金额:
$22.19万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-05-01 至 2023-10-31

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中文摘要
翻译
摘要 失控进食(LOC),即无法控制摄入量的感觉,是暴食的标志 暴饮型进食障碍的一个明确的因果前置因素1,2.进食LOC也预示着焦虑症 和抑郁,作为食物成瘾的核心症状,数百万超重者8,12,17-21岁。 在临床上,进食LOC的严重程度预示着更多的进食障碍病理和情绪失调; 冲动和抑制控制受损;减肥手术后体重减轻22-30岁。LoC预测到了这些 独立于并比28,31-41的进食量更有效地测量并预测体重增加 代谢综合征风险1,2,29,45-51。最近的心理测量学发现也表明,LOC的行为迹象 与认知或情感LOC标准43相比,进食障碍、病理和暴饮暴食的相关性更大。 因此,我们开发了一种新的LOC进食模型,在该模型中,大鼠断断续续地、延长了对可口食物的接触 食物在人体尺度上显示出行为LOC的特征,包括食物导向的努力和摄入量增加 尽管有负面后果,但在本应用程序中,我们将进一步开发模型以获得 另外,与翻译相关的行为LOC衡量标准(目标1)。我们还将使用敏感、具体的 AAV E-sARE使活跃人群中神经元活性依赖的靶向重组(TRAP)(AIM 2)为了解剖最近发现的与LOC样进食有关的前岛神经元群。这个 研究将告知间歇性、延长通路在行为LOC的病因学和模型化中的作用 翻译研究。他们还将确定与LOC相关的群体的位置、分子标记和 因果角色。最后,通过利用英国生物库基因关联数据的整体翻译组结果, 该项目可能会为食用低碳水化合物确定新的治疗靶点。
英文摘要
ABSTRACT Loss of control (LOC) eating, the sense of being unable to control one’s intake, is a hallmark of binge eating and a defining, causal antecedent of binge-type eating disorders 1,2. LOC eating also predicts anxiety disorders and depression and, as a core symptom of food addiction is seen in millions of overweight individuals 8,12,17-21. Clinically, the severity of LOC eating predicts more eating disorder pathology and emotion dysregulation; impulsivity and impaired inhibitory control; and less weight loss post-bariatric surgery 22-30. LOC predicts these measures independent from and more effectively than does the amount eaten 28,31-41 and foretells weight gain and metabolic syndrome risk 1,2,29,45-51. Recent psychometric finding also suggest that behavioral signs of LOC correlate more with eating disorder pathology and binge eating than do cognitive or affective LOC criteria 43. We thus developed a novel model of LOC eating in which rats with intermittent, extended access to palatable food show hallmarks of behavioral LOC in human scales, including increased food-directed effort and intake despite negative consequences, In the present application we will develop the model further to obtain additional, translationally-relevant measures of behavioral LOC (Aim 1). We also will use a sensitive, specific AAV E-SARE to enable neuronal activity-dependent targeted recombination in active populations (TRAP) (Aim 2) in order to dissect a recently identified anterior insula neuronal ensemble implicated in LOC-like eating. The studies will inform the role of intermittent, extended access in the etiology and modeling of behavioral LOC for translational studies. They also will identify the LOC-associated ensemble’s location, molecular markers and causal role. Finally, by leveraging ensemble translatome results with UK Biobank gene association data, the project may identify novel therapeutic targets for LOC eating.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/j.neuropharm.2021.108556
发表时间: 2021-09-15
期刊: Neuropharmacology
影响因子: 4.7
作者: [Serafine KM, O'Dell LE, Zorrilla EP]
通讯作者: Zorrilla EP
DOI: 10.1016/j.neuropharm.2022.108980
发表时间: 2022-05-01
期刊: NEUROPHARMACOLOGY
影响因子: 4.7
作者: [Kirson, Dean, Bagsic, Samantha R. Spierling, Murphy, Jiayuan, Chang, Hang, Vlkolinsky, Roman N., Pucci, Sarah, Prinzi, Julia A., Williams, Casey Y., Fang, Savannah, Roberto, Marisa P., Zorrilla, Eric]
通讯作者: Zorrilla, Eric
PPARdelta receptors and alcohol use phenotypes
  • 批准号:
    10682348
  • 项目类别:
  • 资助金额:
    $21.49万
  • 财政年份:
    2023
  • 负责人:
    ERIC P ZORRILLA
  • 依托单位:
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
  • 批准号:
    10329951
  • 项目类别:
  • 资助金额:
    $39.94万
  • 财政年份:
    2021
  • 负责人:
    ERIC P ZORRILLA
  • 依托单位:
TRAPping loss of control in binge eating
  • 批准号:
    10219019
  • 项目类别:
  • 资助金额:
    $26.63万
  • 财政年份:
    2021
  • 负责人:
    ERIC P ZORRILLA
  • 依托单位:
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
  • 批准号:
    10544021
  • 项目类别:
  • 资助金额:
    $39.94万
  • 财政年份:
    2021
  • 负责人:
    ERIC P ZORRILLA
  • 依托单位:
海外基金