TRAPping loss of control in binge eating
TRAPping loss of control in binge eating
批准号:
10397637
负责人:
ERIC P ZORRILLA
金额:
$22.19万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-05-01 至 2023-10-31
关键词:
AffectiveAffinity ChromatographyAnimal ModelAnimalsAnteriorAnxiety DisordersAttentionBehaviorBehavioralBehavioral ModelBinge EatingBinge eating disorderBody Weight decreasedBulimiaClinicalClinical ResearchCognitiveDataDesire for foodDevelopmentEatingEating DisordersElectrophysiology (science)EtiologyExposure toExtinction (Psychology)FoodFutureGene ExpressionGenesGenetic RecombinationGoalsHumanImpairmentImpulsivityIndividualInsula of ReilIntakeLocationMeasuresMental DepressionMental HealthMetabolic syndromeModelingMolecularMolecular ProfilingNeurobiologyNeuronsOdorsOverweightPalatePathologyPatientsPopulationProceduresProcessPsychometricsPsychopathologyRattusResearch Domain CriteriaResistanceRewardsRibosomesRiskRodentRoleSelf AdministrationSeveritiesSignal TransductionStimulusSymptomsTestingTranslatingViralWeight GainWomanWorkanorexia nervosa binge-purge subtypebariatric surgerybehavior measurementbiobankcell typecognitive controlcombinatorialemotion dysregulationexperiencefood addictiongenetic approachindexinginnovationinsightloss of control over eatingmolecular markermultidisciplinarynew therapeutic targetnoveloptogeneticsrecruitresponseribosome profilingsocialtranslational studytranslatome
中文摘要
摘要
进食失控,即无法控制自己的进食量,是暴饮暴食的标志
以及暴饮暴食型饮食失调的定义性因果前因1,2。暴饮暴食也预示着焦虑症
和抑郁症,并且作为食物成瘾的核心症状,在数百万超重个体中可见8,12,17 -21。
临床上,暴食的严重程度预示着更多的饮食失调病理和情绪失调;
冲动和抑制控制受损;减肥手术后体重减轻较少22-30。预测这些
措施独立于和更有效地比吃的量28,31 -41和预示体重增加
和代谢综合征风险1,2,29,45 -51。最近的心理测量发现也表明,
与进食障碍病理学和暴饮暴食的相关性高于认知或情感障碍标准43。
因此,我们开发了一种新的进食模型,在该模型中,大鼠间歇性地,
食物在人类尺度上表现出行为失调的特征,包括增加食物导向的努力和摄入
在本申请中,我们将进一步开发该模型以获得
额外的,预防性相关的行为障碍措施(目标1)。我们还将使用一个敏感的,具体的
AAVE-SARE能够在活性群体中实现神经元活性依赖性靶向重组(TRAP)(Aim
2)为了解剖最近发现的与LOC样进食有关的前额叶神经元系综。的
研究将告知间歇性的作用,延长访问的病因学和建模的行为障碍,
翻译研究他们还将确定与LOC相关的集合的位置,分子标记和
因果作用。最后,通过利用集成翻译组结果与英国生物库基因关联数据,
该项目可能会发现新的治疗目标,为肥胖。
英文摘要
ABSTRACT
Loss of control (LOC) eating, the sense of being unable to control one’s intake, is a hallmark of binge eating
and a defining, causal antecedent of binge-type eating disorders 1,2. LOC eating also predicts anxiety disorders
and depression and, as a core symptom of food addiction is seen in millions of overweight individuals 8,12,17-21.
Clinically, the severity of LOC eating predicts more eating disorder pathology and emotion dysregulation;
impulsivity and impaired inhibitory control; and less weight loss post-bariatric surgery 22-30. LOC predicts these
measures independent from and more effectively than does the amount eaten 28,31-41 and foretells weight gain
and metabolic syndrome risk 1,2,29,45-51. Recent psychometric finding also suggest that behavioral signs of LOC
correlate more with eating disorder pathology and binge eating than do cognitive or affective LOC criteria 43.
We thus developed a novel model of LOC eating in which rats with intermittent, extended access to palatable
food show hallmarks of behavioral LOC in human scales, including increased food-directed effort and intake
despite negative consequences, In the present application we will develop the model further to obtain
additional, translationally-relevant measures of behavioral LOC (Aim 1). We also will use a sensitive, specific
AAV E-SARE to enable neuronal activity-dependent targeted recombination in active populations (TRAP) (Aim
2) in order to dissect a recently identified anterior insula neuronal ensemble implicated in LOC-like eating. The
studies will inform the role of intermittent, extended access in the etiology and modeling of behavioral LOC for
translational studies. They also will identify the LOC-associated ensemble’s location, molecular markers and
causal role. Finally, by leveraging ensemble translatome results with UK Biobank gene association data, the
project may identify novel therapeutic targets for LOC eating.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.neuropharm.2022.108980
发表时间:
2022-05-01
期刊:
NEUROPHARMACOLOGY
影响因子:
4.7
作者:
[Kirson, Dean, Bagsic, Samantha R. Spierling, Murphy, Jiayuan, Chang, Hang, Vlkolinsky, Roman N., Pucci, Sarah, Prinzi, Julia A., Williams, Casey Y., Fang, Savannah, Roberto, Marisa P., Zorrilla, Eric]
通讯作者:
Zorrilla, Eric
DOI:
10.1016/j.neuropharm.2021.108556
发表时间:
2021-09-15
期刊:
Neuropharmacology
影响因子:
4.7
作者:
[Serafine KM, O'Dell LE, Zorrilla EP]
通讯作者:
Zorrilla EP
PPARdelta receptors and alcohol use phenotypes
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批准号:10682348
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项目类别:
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资助金额:$21.49万
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财政年份:2023
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负责人:ERIC P ZORRILLA
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依托单位:
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
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批准号:10329951
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项目类别:
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资助金额:$39.94万
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财政年份:2021
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负责人:ERIC P ZORRILLA
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依托单位:
TRAPping loss of control in binge eating
-
批准号:10219019
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项目类别:
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资助金额:$26.63万
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财政年份:2021
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负责人:ERIC P ZORRILLA
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依托单位:
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
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批准号:10544021
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项目类别:
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资助金额:$39.94万
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Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
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依托单位:
Component 8: Zorrilla
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批准号:8374917
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资助金额:$19.5万
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财政年份:2012
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依托单位:
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财政年份:2010
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负责人:ERIC P ZORRILLA
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依托单位:
Urocortins Brain CRF2 Receptors and Energy Balance
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批准号:7892017
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财政年份:2009
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负责人:ERIC P ZORRILLA
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依托单位:
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批准号:7849888
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资助金额:$3.39万
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财政年份:2009
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依托单位:
Component 8: Zorrilla
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财政年份:2008
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依托单位:
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资助金额:$32.22万
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财政年份:2008
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Programmed adiposity: genetic in utero and postnatal determinants
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财政年份:2006
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财政年份:2006
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依托单位:
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财政年份:2006
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资助金额:$18.77万
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海外基金