Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
背侧纹状体磷酸二酯酶 10A 和强迫性乙醇使用
基本信息
- 批准号:10660892
- 负责人:
- 金额:$ 13.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-15 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:Adenylate CyclaseAdministrative SupplementAffectiveAgeAlcohol abuseAlcohol consumptionAlcoholsAmericanBehavioralCREB1 geneChronicCorpus striatum structureCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic GMPDARPPDataData SetDiagnosisDiseaseDorsalEthanolGenesGeneticGenotypeGuanylate CyclaseInvestigationLinkMental disordersMorbidity - disease rateNeurobiologyNeuronsObesityPDE2 phosphodiesterasePathway interactionsPersonsPopulationProtein IsoformsProteinsRelapseRoleTestingUnited Statesalcohol use disorderbiobankcomorbiditydifferential expressiondrinkingethnic diversitygenetic regulatory proteingenetic variantinhibitorinsightmembermotor behaviormultidisciplinarynew therapeutic targetnovelparent grantphosphoric diester hydrolasepsychiatric comorbiditypsychogeneticsputamenruminationsocial health determinantssocioeconomic diversitysocioeconomicswhole genome
项目摘要
ABSTRACT
Alcohol use disorder (AUD) is a chronic, relapsing disorder that afflicts 29% of Americans in their lifetime1,2,
is disabling2 and increases mortality3. New drug targets and neurobiological insight for AUD are needed.
Guided by preliminary data, this administrative supplement seeks to expand studies of gene variants in
phosphodiesterase 10A (PDE10A) performed in the UK Biobank (and related phosphodiesterases, adenylyl
cyclases and protein kinase A-related proteins that regulate alcohol-related cAMP cascades) to studies in the
ethincally and socioeconomically diverse All of Us dataset. Specially, Aim 1 will use both genotyped arrays
and whole genome sequence datasets to identify PDE10A gene variants that associate with problematic
alcohol use, as defined by AUDIT-C scores and alcohol use-associated diagnoses, as well as their expression
and genetic correlation to often comorbid psychiatric and obesity-related diagnoses. This administrative
supplement will increase the impact of the parent grant to identify novel gene variants in PDE10A and other
cAMP-cascade regulating genes towards repurposing novel translatable PDE inhibitors to treat AUD. The
supplement will increase the sensitivity and generalizability of genetic discovery to reflect the age, ethnic, and
socioeconomic diversity of the American population. Extending our analyses to the All of Us dataset is pressing
given the known role of inequitable social determinants of health, interacting with genetic factors, in alcohol-
related morbidity and comorbidity within the United States.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ERIC P ZORRILLA其他文献
ERIC P ZORRILLA的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ERIC P ZORRILLA', 18)}}的其他基金
PPARdelta receptors and alcohol use phenotypes
PPARδ 受体和饮酒表型
- 批准号:
10682348 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
背侧纹状体磷酸二酯酶 10A 和强迫性乙醇使用
- 批准号:
10329951 - 财政年份:2021
- 资助金额:
$ 13.31万 - 项目类别:
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
背侧纹状体磷酸二酯酶 10A 和强迫性乙醇使用
- 批准号:
10544021 - 财政年份:2021
- 资助金额:
$ 13.31万 - 项目类别:
Extrahypothalamic PPARs and compulsive food intake
下丘脑外 PPAR 和强迫性食物摄入
- 批准号:
9746543 - 财政年份:2020
- 资助金额:
$ 13.31万 - 项目类别:
Urocortins Brain CRF2 Receptors and Energy Balance
尿皮质素大脑 CRF2 受体和能量平衡
- 批准号:
8007028 - 财政年份:2010
- 资助金额:
$ 13.31万 - 项目类别:
Urocortins Brain CRF2 Receptors and Energy Balance
尿皮质素大脑 CRF2 受体和能量平衡
- 批准号:
7892017 - 财政年份:2009
- 资助金额:
$ 13.31万 - 项目类别:
Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
甘丙肽控制食物摄入:分子、神经解剖学和行为基础
- 批准号:
7849888 - 财政年份:2009
- 资助金额:
$ 13.31万 - 项目类别:
相似海外基金
Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity - Administrative Supplement
质子分泌上皮细胞作为附睾粘膜免疫的关键调节剂 - 行政补充
- 批准号:
10833895 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
A Longitudinal Qualitative Study of Fentanyl-Stimulant Polysubstance Use Among People Experiencing Homelessness (Administrative supplement)
无家可归者使用芬太尼兴奋剂多物质的纵向定性研究(行政补充)
- 批准号:
10841820 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
StrokeNet Administrative Supplement for the Funding Extension
StrokeNet 资助延期行政补充文件
- 批准号:
10850135 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
2023 NINDS Landis Mentorship Award - Administrative Supplement to NS121106 Control of Axon Initial Segment in Epilepsy
2023 年 NINDS 兰迪斯指导奖 - NS121106 癫痫轴突初始段控制的行政补充
- 批准号:
10896844 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
Biomarkers of Disease in Alcoholic Hepatitis Administrative Supplement
酒精性肝炎行政补充剂中疾病的生物标志物
- 批准号:
10840220 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
Administrative Supplement: Life-Space and Activity Digital Markers for Detection of Cognitive Decline in Community-Dwelling Older Adults: The RAMS Study
行政补充:用于检测社区老年人认知衰退的生活空间和活动数字标记:RAMS 研究
- 批准号:
10844667 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
Administrative Supplement: Improving Inference of Genetic Architecture and Selection with African Genomes
行政补充:利用非洲基因组改进遗传结构的推断和选择
- 批准号:
10891050 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
Power-Up Study Administrative Supplement to Promote Diversity
促进多元化的 Power-Up 研究行政补充
- 批准号:
10711717 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
Administrative Supplement for Peer-Delivered and Technology-Assisted Integrated Illness Management and Recovery
同行交付和技术辅助的综合疾病管理和康复的行政补充
- 批准号:
10811292 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别:
Sedentary behavior, physical activity, and 24-hour behavior in pregnancy and offspring health: the Pregnancy 24/7 Offspring Study Administrative Supplement
久坐行为、体力活动和 24 小时行为对怀孕和后代健康的影响:怀孕 24/7 后代研究行政补充
- 批准号:
10893074 - 财政年份:2023
- 资助金额:
$ 13.31万 - 项目类别: