An Examination of the Effects of PTSD Symptom Severity and Global Sleep Disturbance on Alcohol Cue Reactivity

检查 PTSD 症状严重程度和整体睡眠障碍对酒精提示反应的影响

• 批准号: 10397689
• 负责人: Lia Jean Smith
• 金额: $ 3.63万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10397689
• 关键词: Address; Affect; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Arousal; Attention; Award; Behavior; Chronic; Clinical; Complex; Cues; DSM-V; Diagnostic; Disease; Emotional; Etiology; Evidence based intervention; Foundations; Goals; Gold; Health; Health Personnel; Impaired health; Individual; Institutes; Intention; Interview; Investigation; Knowledge; Link; Maintenance; Measures; Mental Health; Mission; Modeling; Participant; Patient Self-Report; Physiologic Monitoring; Placebo Effect; Post-Traumatic Stress Disorders; Prevalence; Prevention; Recording of previous events; Reporting; Research; Research Methodology; Research Personnel; Risk; Role; Severities; Sleep; Sleep Disorders; Sleep disturbances; Statistical Data Interpretation; Strategic Planning; Sum; Symptoms; Testing; Training; Translating; Trauma; Visual; Work; alcohol abuse therapy; alcohol availability; alcohol comorbidity; alcohol craving; alcohol cue; alcohol exposure; alcohol measurement; alcohol risk; alcohol use disorder; analog; base; biobehavior; biological adaptation to stress; biopsychosocial factor; comorbidity; cost; craving; cue reactivity; evidence base; falls; heart rate variability; improved; meetings; recruit; response; standard care; study population; symptomatology; trauma exposure; traumatic stress; treatment research

PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are complex psychiatric conditions that commonly co-occur. The AUD/PTSD comorbidity is marked by a more costly, severe, and chronic clinical course, when compared to either disorder alone. Current treatment approaches for AUD/PTSD are characterized by small effect sizes and significant attrition. A key avenue for informing our understanding of AUD/PTSD includes focusing our scientific attention to transdiagnostic, malleable mechanisms that significantly impact the AUD/PTSD comorbidity. Global sleep disturbance represents one potential contributor. Specifically, global sleep disturbance, particularly among those with PTSD symptoms, may contribute to the maintenance of the AUD by increasing reactivity to negative emotionality, which may thus increase alcohol craving. Against this background, the objectives of the current application are to: (a) determine the extent to which PTSD symptom severity is associated with alcohol craving as measured by emotional reactivity to alcohol and trauma cues and (b) examine global sleep disturbance as a moderator of the relationship between PTSD symptom severity and alcohol craving as measured by emotional reactivity to alcohol and trauma cues. The central hypothesis of this project is that global sleep disturbance moderates, or exacerbates, the relationship between PTSD symptom severity and alcohol craving as measured by emotional reactivity to alcohol and trauma cues. The approach is to recruit 60 individuals for a cue-reactivity experimental paradigm that will test the effects of PTSD symptom severity and global sleep disturbance on alcohol craving as measured by emotional reactivity to alcohol and trauma cues. Study candidates will meet criteria for current (past month) DSM-5 AUD, reporting a history of trauma exposure per DSM-5 PTSD Criterion A, and current (past month) subclinical (one symptom per cluster) or diagnostic DSM-5 PTSD (N = 60). At the completion of this project, it is the expectation that the effects of PTSD symptom severity and global sleep disturbance on alcohol cue reactivity will be further elucidated. The impact of this study is improved understanding of mechanisms related to AUD/PTSD, a complex comorbidity with significant health burden. The proposed project coordinates with the mission statement of the National Institute of Alcohol Abuse and Alcoholism (NIAAA) with its emphasis on the health risks of alcohol consumption, prevention, and treatment, and with its emphasis on increasing the understanding of normal and abnormal behavior relating to alcohol use. Ultimately, in accord with the strategic planning goals of NIAAA, the research findings will be translated and disseminated to health care providers, researchers, policymakers, and the public. In sum, this award will support substantial training in research methods, statistical analysis, and dissemination to a promising young researcher and will address a significant need for an experimental investigation of the effects of PTSD symptom severity and global sleep disturbance on alcohol cue reactivity among those suffering from AUD/PTSD.

项目总结/文摘