Hippocampal and prefrontal contributions to memory integration

海马和前额叶对记忆整合的贡献

• 批准号: 10397574
• 负责人: Alison R Preston
• 金额: $ 66.14万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-17 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10397574
• 关键词: Adolescence; Adolescent; Adult; Age; Anterior; Award; Behavior; Brain; Child; Childhood; Code; Cognitive; Data; Decision Making; Development; Diagnosis; Environment; Event; Fragile X Syndrome; Functional Magnetic Resonance Imaging; Goals; Hippocampus (Brain); Human; Individual; Influentials; Intervention; Knowledge; Learning; Location; Maps; Measures; Medial; Mediating; Memory; Memory impairment; Mental Depression; Mental Health; Mental disorders; Methods; Neurodevelopmental Disorder; Outcome; Participant; Pattern; Prefrontal Cortex; Process; Research; Resolution; Retrieval; Schizophrenia; Structure; System; Testing; Time; Work; age related; autism spectrum disorder; cognitive ability; cognitive development; experience; flexibility; improved; neuromechanism; public health relevance; relating to nervous system; spatial integration; spatial memory; statistical learning; theories; therapy design; virtual environment

PROJECT SUMMARY/ABSTRACT Hippocampus (HPC) and prefrontal cortex (PFC) structure and connectivity continue to develop through childhood and adolescence, developmental periods that are associated with substantial gains in memory and cognitive ability. While such structural changes are well documented, we know little about the functions that HPC and PFC development confer, fundamentally limiting our understanding of the mechanisms of cognitive development. The overarching goal of this proposal is to test the hypothesis that the representational capacity of the HPC—PFC memory circuit transforms across development from a system that stores individual memories in childhood to a mature system in adulthood wherein cognitive maps represent the relationships among multiple episodes. Cognitive maps allow memory to extend beyond direct experience by coding unobserved relationships among multiple events. In the absence of a mature HPC—PFC system, such knowledge extension through cognitive map formation may be limited in children and adolescents, and therefore result in development differences in learning, decision making, and reasoning behaviors that require consideration of the relationships among multiple events. Moreover, the differential time course of HPC and PFC development, in which mature HPC function may emerge earlier than that of PFC, suggests there may be distinct patterns of memory representation and behavior in adolescence that differ from both childhood and adulthood. To answer these open questions, the proposed studies use a combination of high-resolution functional magnetic resonance imaging (fMRI) and sophisticated multivariate pattern analyses in children (7-9 years), younger adolescents (10-12 years), older adolescents (13-15 years), and adults (25-30 years). Using these methods, we will quantify: (1) age-related differences in HPC—PFC memory integration and separation strategies that support cognitive map formation and (2) how developmental differences in neural representation impact temporal (Aim 1), spatial (Aim 2), and event memory (Aim 3). Collectively, the results from this project will provide a key test of fundamental theories of cognitive development and substantially advance our knowledge of the representational capacities of the HPC—PFC memory system at different ages. In doing so, the findings have the potential to inform interventions designed to enhance memory and reasoning abilities that rely on cognitive maps, including in individuals diagnosed with mental health or neurodevelopmental disorders associated with memory deficits (e.g., autism, depression, Fragile X, or schizophrenia). .

项目总结/文摘

项目成果

Building concepts one episode at a time: The hippocampus and concept formation.

• DOI: 10.1016/j.neulet.2017.07.061
• 发表时间: 2018-07-27
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Mack ML;Love BC;Preston AR
• 通讯作者: Preston AR

Concept formation as a computational cognitive process.

• DOI: 10.1016/j.cobeha.2020.12.005
• 发表时间: 2021-04
• 期刊: Current opinion in behavioral sciences
• 影响因子: 5
• 作者: Morton NW;Preston AR
• 通讯作者: Preston AR

Memory integration constructs maps of space, time, and concepts.

• DOI: 10.1016/j.cobeha.2017.08.007
• 发表时间: 2017-10
• 期刊: Current opinion in behavioral sciences
• 影响因子: 5
• 作者: Morton NW;Sherrill KR;Preston AR
• 通讯作者: Preston AR

Repetition suppression in the medial temporal lobe and midbrain is altered by event overlap.

• DOI: 10.1002/hipo.22622
• 发表时间: 2016-11
• 期刊: HIPPOCAMPUS
• 影响因子: 3.5
• 作者: Zeithamova, Dagmar;Manthuruthil, Christine;Preston, Alison R.
• 通讯作者: Preston, Alison R.

Abstract Representation of Prospective Reward in the Hippocampus.

海马体中预期奖励的抽象表示。

• DOI: 10.1523/jneurosci.0719-18.2018
• 发表时间: 2018
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Zeithamova,Dagmar;Gelman,BernardD;Frank,Lea;Preston,AlisonR
• 通讯作者: Preston,AlisonR