HIGH-RESOLUTION FMRI OF HIPPOCAMPAL SUBFIELD CONTRIBUTIONS TO EPISODIC MEMORY

海马亚区对情景记忆贡献的高分辨率 FMRI

• 批准号: 8362902
• 负责人: Alison R Preston
• 金额: $ 1.3万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362902
• 关键词: Address; Annual Reports; Attention; Dependence; Episodic memory; Event; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Grant; Hippocampal Formation; Hippocampus (Brain); Human; Individual; Learning; Magnetic Resonance; Medial; Memory; National Center for Research Resources; Nature; Organism; Principal Investigator; Reading; Research; Research Infrastructure; Resolution; Resources; Retrieval; Role; Source; Structure; Technology; Temporal Lobe; Testing; United States National Institutes of Health; Visit; abstracting; cost; dentate gyrus; flexibility; imaging modality; memory process; research study; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Episodic memorymemory for individual eventspermits an organism to bridge the past with the present, providing information about prior events that serves to inform present decisions and action. Episodic memory critically depends on the medial temporal lobe (MTL) circuit, which is composed of multiple structures, including the hippocampal formation [dentate gyrus (DG), CA fields, and subiculum (SUB)] and the surrounding entorhinal (ERc), perirhinal (PRc), and parahippocampal (PHc) cortices. Though decades of research have aimed to characterize the role of MTL in episodic memory, fundamental questions remain regarding the functional contributions of specific MTL substructures. Recent advances in functional imaging methods have made it possible to address these questions in humans. Our research uses high-resolution fMRI to delineate the role of hippocampal subfields and MTL cortical structures in the encoding and retrieval of episodic memories. The experiments test anatomically-informed theory-driven hypotheses regarding the nature of episodic memory and its dependence on MTL function. The research further examines optimal learning parameters to promote the flexible, generative use of episodic memory, and the potential impact of motivational salience and attention on episodic memory processing and MTL function. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 情景记忆个别事件记忆允许有机体连接过去和现在， 关于先前事件的信息，用于通知当前的决定和行动。情景记忆主要取决于 内侧颞叶（MTL）回路，由包括海马结构在内的多个结构组成 [齿状回（DG）、CA区和下托（DG）]和周围的内嗅（ERc）、嗅周（PRc），以及 海马旁（PHc）皮质。尽管数十年的研究旨在描述MTL在发作性疾病中的作用， 记忆，基本问题仍然是关于特定MTL子结构的功能贡献。最近 功能成像方法的进步使得解决人类的这些问题成为可能。我们的研究使用 高分辨率功能磁共振成像描绘的作用，海马子领域和MTL皮质结构的编码和检索 情景记忆的能力这些实验测试了解剖学上的理论驱动的假设， 情景记忆及其对MTL功能的依赖性。该研究进一步研究了最佳学习参数， 促进情景记忆的灵活性和生成性使用，以及动机显著性和注意力的潜在影响 对情景记忆加工和MTL功能的影响。 要了解卢卡斯中心正在进行的其他项目，请访问www.example.com （卢卡斯年度报告和 ISMRM 2011摘要）