HIGH-RESOLUTION FMRI OF HIPPOCAMPAL SUBFIELD CONTRIBUTIONS TO EPISODIC MEMORY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 情节记忆对个人事件的记忆为有机体搭建了过去与现在的桥梁，提供了 关于以前事件的信息，用于为当前的决定和行动提供信息。情节记忆严重依赖于 内侧颞叶(MTL)回路，由多个结构组成，包括海马结构 [齿状回(DG)、CA区和下丘脑(SUB)]及其周围的内嗅区(ERC)、周边区(PRC)和 海马旁(PHC)皮质。尽管几十年的研究旨在表征MTL在发作性疾病中的作用 关于记忆，关于特定MTL亚结构的功能贡献的基本问题仍然存在。近期 功能成像方法的进步使在人类身上解决这些问题成为可能。我们的研究使用了 高分辨率功能磁共振成像描绘海马亚区和MTL皮质结构在编码和提取中的作用 关于情节的记忆。这些实验测试了解剖学信息的理论驱动的关于脑血管疾病本质的假说 情景记忆及其对MTL功能的依赖这项研究进一步检查了最佳学习参数以 促进情景记忆的灵活、生成使用，以及激励性突显和注意力的潜在影响 论情景记忆加工与MTL功能。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/(卢卡斯年度报告和 ISMRM 2011年摘要)

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Episodic memorymemory for individual eventspermits an organism to bridge the past with the present, providing information about prior events that serves to inform present decisions and action. Episodic memory critically depends on the medial temporal lobe (MTL) circuit, which is composed of multiple structures, including the hippocampal formation [dentate gyrus (DG), CA fields, and subiculum (SUB)] and the surrounding entorhinal (ERc), perirhinal (PRc), and parahippocampal (PHc) cortices. Though decades of research have aimed to characterize the role of MTL in episodic memory, fundamental questions remain regarding the functional contributions of specific MTL substructures. Recent advances in functional imaging methods have made it possible to address these questions in humans. Our research uses high-resolution fMRI to delineate the role of hippocampal subfields and MTL cortical structures in the encoding and retrieval of episodic memories. The experiments test anatomically-informed theory-driven hypotheses regarding the nature of episodic memory and its dependence on MTL function. The research further examines optimal learning parameters to promote the flexible, generative use of episodic memory, and the potential impact of motivational salience and attention on episodic memory processing and MTL function. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)