Adaptive Platform for Personalized Engagement

项目总结/摘要 PMI队列计划（PMI-CP）将建立一个由100万或更多美国志愿者组成的国家研究队列 他们作为合作伙伴参与了一项纵向努力， 个人健康和疾病。精准医学倡议（PMI）工作组报告（PMI-WGR） 建议3.3：所有居住在美国的个人都应该能够自愿参加PMI队列。作为 作为以患者为中心的研究的长期支持者，Vibrent了解参与者技术中心 (PTC)PMI协作的一个组成部分是使命关键。参与者必须通过互联网参与 启用体验并保持参与。该提案提供了这样一种方法，即参与、鼓励、 激励，保留和维持一个具有全国代表性的队列。该提案使用当前的技术 例如移动的电话、网站和功能电话，以实现PMI队列计划的目标， 并允许不断发展的消费者技术，如无线传感器，可穿戴设备和不断发展的 平衡创新与稳健性和可扩展性的科学。 我们通过参与和保留三元模型提出了一种创新和强大的方法。 参与者参与和授权是PMI-CP的核心价值，我们的PTC方法将 使用PCRI参与原则，促进参与者和研究人员之间的伙伴关系。 我们的建议将部署一个由三大支柱--技术、科学和支持--支持的基础设施， 以吸引、维持和扩大这一群体。每个支柱都将通过以下过程不断改进： “测量-学习-学习”。这将使适应性和个性化，以确保长期的成功， PMI计划。 通过参与合作研究项目和大型财团，我们的团队拥有 专业知识，通过协调一致，整合和协同作用，在四个组成部分提供管理， PMI-CP（PTC、CC、HPO、生物库）。我们将为参与者的参与提供基础设施， 在深度和广度上进行扩展的通信。

Project Summary/Abstract The PMI Cohort Program (PMI-CP) will build a national research cohort of one million or more U.S. volunteers who are engaged as partners in a longitudinal effort to transform the understanding of factors contributing to individual health and disease. Per the Precision Medicine Initiative (PMI) Working Group Report (PMI-WGR) Recommendation 3.3: All individuals living in the U.S. should be able to volunteer for the PMI cohort. As a long-time proponent of patient-centered research, Vibrent understands that the Participant Technology Center (PTC) component of the PMI collaboration is mission critical. Participants must be engaged through internet enabled experiences and remain engaged. This proposal provides such an approach to Engage, Encourage, Motivate, Retain and Sustain a nationally representative Cohort. The proposal uses current technologies such as mobile phones, website and feature phones to achieve the objectives of the PMI Cohort Program as well as allow for evolving consumer technologies such as wireless sensors, wearables and evolving science that balance innovation with robustness and scalability. We are proposing an innovative and robust approach through an Engagement and Retention Triad Model. Participant engagement and empowerment are core values for the PMI-CP and our PTC approach would enable and promote partnership between participants and researchers using PCORI Engagement Principles. Our proposal will deploy an infrastructure supported by the three pillars – Technology, Science and Support in order to engage, sustain and scale the cohort. Each pillar will continuously improve through a process of “measure-learn-iterate”. This will enable adaptability and personalization to ensure long term success of the PMI program. Through participation in collaborative research projects and large-scale consortiums, our team has the expertise to provide stewardship through coherence, integration, and synergy across the four components of the PMI-CP (PTC, CC, HPO, biobank). We will provide the infrastructure for participant engagement and communication that will scale in depth and breadth.